Acute toxicity study of an aqueous extract of Ficus racemosa Linn. bark in albino mice

10.5580/1094 ◽  
2009 ◽  
Vol 6 (1) ◽  
Keyword(s):  
Acute Toxicity ◽  
Aqueous Extract ◽  
Toxicity Study ◽  
Acute Toxicity Study ◽  
Ficus Racemosa ◽  
Albino Mice

In-vitro and in-vivo evaluation of antidiabetic activity of Withania coagulans extract

2019 ◽  
Vol 09 ◽  
Author(s):  
Tejas Patel ◽  
B.N. Suhagia
Keyword(s):  
Blood Glucose ◽  
Acute Toxicity ◽  
Aqueous Extract ◽  
Pancreatic Beta Cell ◽  
Toxicity Study ◽  
Acute Toxicity Study ◽  
Withania Coagulans ◽  
Study Results

Background: Diabetes mellitus is major issue to public health as its prevalence is rising day by day. Synthetic agents available for the diabetic treatment are expensive or produce undesirable side effect on chronic use and some of them are not suitable during pregnancy. Herbal medicines accepted widely due to side effects and low cost. Objective: The aim of present study was to evaluate the activity of Withania coagulans extract using In-vitro and In-vivo model. Methods: Different three types of Withania coagulans extract were prepared using aqueous (W1), Alcohol (W2) and hydro-alcoholic (50:50) mixture (W3). In-vitro Anti-diabetic activity of the all three extracts evaluated using RINm5F Pancreatic beta cells.Further, n-vivo anti-diabetic evaluation performed by administering 50 mg/kg (p.o) aqueous extract for 7 days in Streptozotocin (STZ)-induced mice. Body weight of the animals was also determined to perform acute toxicity study. Results: The results of in –vitro cell based study indicated that among all three extract, aqueous extract (W1) of Withania coagulans showed potential increase in inulin release. The EC50 of the W1 (249.6 µg/L) which is compared with standard (Glibenclamide) EC50. From the results of In-vitro study, W1 subjected for acute toxicity study and the acute toxicity study results indicated LD50 of 50mg/kg. Diabetic rats treated with W1 extract at oral dose of 50 mg/kg for 7 days showed 34.17% reduction in blood glucose in comparison to untreated diabetic (STZ-induced) rats. Blood glucose levels of Standard treated (Glibenclamide) and control untreated. Conclusion: In conclusion, results of pancreatic beta cell based study showed increase in insulin release by administration of extract. Further aqueous extract (W1) was potentially reduced blood glucose level in STZ induced diabetic mice.

scholarly journals Acute Toxicity Study of Standardized Mitragyna speciosa Korth Aqueous Extract in Sprague Dawley Rats

2012 ◽  
Vol 1 (2) ◽  
Author(s):  
Mohd Saleh Ahmad Kamal ◽  
Ahmad Rohi Ghazali ◽  
Noral ‘Ashikin Yahya ◽  
Mohd Isa Wasiman ◽  
Zakiah Ismail
Keyword(s):  
Acute Toxicity ◽  
Aqueous Extract ◽  
Toxicity Study ◽  
Sprague Dawley ◽  
Mitragyna Speciosa ◽  
Acute Toxicity Study ◽  
Sprague Dawley Rats

Sub-acute toxicity study on the aqueous extract of Albizia zygia stem bark

2016 ◽  
Vol 13 (1) ◽  
pp. 32 ◽  
Author(s):  
Stephen O. Okpo ◽  
Clare O. Igwealor ◽  
Gerald I. Eze
Keyword(s):  
Acute Toxicity ◽  
Aqueous Extract ◽  
Stem Bark ◽  
Toxicity Study ◽  
Acute Toxicity Study

scholarly journals Preliminary acute toxicity study on imidacloprid in Swiss albino mice

2013 ◽  
Vol 6 (12) ◽  
pp. 955-959 ◽  
Author(s):  
Preeti Bagri ◽  
Vinod Kumar ◽  
Anil Kumar Sikka ◽  
Joginder Singh Punia
Keyword(s):  
Acute Toxicity ◽  
Toxicity Study ◽  
Swiss Albino Mice ◽  
Acute Toxicity Study ◽  
Albino Mice

Acute and 28-days repeated dose sub-acute toxicity study of gallic acid in albino mice

2019 ◽  
Vol 101 ◽  
pp. 71-78 ◽  
Author(s):  
Bhavesh C. Variya ◽  
Anita K. Bakrania ◽  
Prem Madan ◽  
Snehal S. Patel
Keyword(s):  
Acute Toxicity ◽  
Gallic Acid ◽  
Toxicity Study ◽  
Repeated Dose ◽  
Acute Toxicity Study ◽  
Albino Mice

scholarly journals Gastroprotective Effects of Lion’s Mane MushroomHericium erinaceus(Bull.:Fr.) Pers. (Aphyllophoromycetideae) Extract against Ethanol-Induced Ulcer in Rats

2013 ◽  
Vol 2013 ◽  
pp. 1-9 ◽  
Author(s):  
Jing-Yang Wong ◽  
Mahmood Ameen Abdulla ◽  
Jegadeesh Raman ◽  
Chia-Wei Phan ◽  
Umah Rani Kuppusamy ◽  
...  
Keyword(s):  
Acute Toxicity ◽  
Aqueous Extract ◽  
Gastric Wall ◽  
Toxicity Study ◽  
Control Group ◽  
High Dose ◽  
Sprague Dawley ◽  
Bax Protein ◽  
Acute Toxicity Study

Hericium erinaceusis a famous tonic in oriental medicine. The gastroprotective effects of aqueous extract ofH. erinaceusagainst ethanol-induced ulcers inSprague Dawleyrats were investigated. The possible involvements of lipid peroxidation, superoxide dismutase, and catalase were also investigated. Acute toxicity study was performed. The effects of aqueous extract ofH. erinaceuson the ulcer areas, ulcer inhibition, gastric wall mucus, gross and histological gastric lesions, antioxidant levels, and malondialdehyde (MDA) contents were evaluated in ethanol-induced ulcerin vivo. In acute toxicity study, a high dose of 5 g/kg did not manifest any toxicological signs in rats. The extract promoted ulcer protection as ascertained by a significant reduction of the ulcer area. Furthermore, it exhibited a significant protection activity against gastric mucosal injury by preventing the depletion of antioxidant enzymes. The level of MDA was also limited in rat stomach tissues when compared with the ulcer control group. Immunohistochemistry showed upregulation of HSP70 protein and downregulation of BAX protein in rats pretreated with the extract. The aqueous extract ofH. erinaceusprotected gastric mucosa in ourin vivomodel. It is speculated that the bioactive compounds present in the extract may play a major role in gastroprotective activity.

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