scholarly journals A case of Muscle Abscess after Intravesical BCG Instillation

2020 ◽  
Vol 25 (3) ◽  
pp. 433-437
Author(s):  
Sevil Alkan Çeviker ◽  
Pınar Korkmaz ◽  
Duru Mıstanoğlu Özatağ ◽  
Özlem Genç ◽  
Mehmet Hüseyin Metineren ◽  
...  
Keyword(s):  
Intravesical Bcg ◽  
Bcg Instillation

scholarly journals Miliary pulmonary tuberculosis after the first dose of intravesical BCG instillation in a patient with high-grade bladder cancer

2020 ◽  
Vol 88 (6) ◽  
pp. 628-629
Author(s):  
Adam Stępień ◽  
Michał Brudło ◽  
Tomasz Stachura ◽  
Paulina Marcinek ◽  
Jerzy Soja ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Pulmonary Tuberculosis ◽  
High Grade ◽  
Intravesical Bcg ◽  
Bcg Instillation

scholarly journals Clinical Spectrum of Complications Induced by Intravesical Immunotherapy of Bacillus Calmette-Guérin for Bladder Cancer

2019 ◽  
Vol 2019 ◽  
pp. 1-11 ◽  
Author(s):  
Yuqing Liu ◽  
Jian Lu ◽  
Yi Huang ◽  
Lulin Ma
Keyword(s):  
Bladder Cancer ◽  
Adverse Reactions ◽  
Clinical Manifestations ◽  
Bacillus Calmette Guerin ◽  
Bcg Immunotherapy ◽  
Bcg Therapy ◽  
Intravesical Bcg ◽  
Proven Efficacy ◽  
Bcg Instillation ◽  
Early Establishment

Because of its proven efficacy, intravesical Bacillus Calmette-Guérin (BCG) immunotherapy is an important treatment for nonmuscle invasive bladder cancer at high risk of recurrence or progression. However, approximately 8% of patients have to stop BCG instillation as a result of its complications. Complications induced by BCG therapy can have a variety of clinical manifestations. These adverse reactions may occur in conjunction with BCG instillation or may not develop until months or years after BCG cessation. An essential step in the management complications arising from BCG is early establishment of diagnosis, particularly for distant, disseminated, and obscure infections. Therefore we reviewed the literature on the potential complications after intravesical BCG immunotherapy for bladder cancer and provide an overview on the incidence, diagnosis, and treatment modality of genitourinary and systemic BCG-induced complications.

scholarly journals BCG instillation versus radical cystectomy for high-risk NMIBC with squamous/glandular histologic variants

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Jungyo Suh ◽  
Kyung Chul Moon ◽  
Jae Hyun Jung ◽  
Junghoon Lee ◽  
Won Hoon Song ◽  
...  
Keyword(s):  
High Risk ◽  
Radical Cystectomy ◽  
Bacillus Calmette Guerin ◽  
Large Tumor ◽  
Treatment Groups ◽  
Appropriate Treatment ◽  
Intravesical Bcg ◽  
Risk Patients ◽  
Cystectomy Group ◽  
Bcg Instillation

Abstract This study aims to evaluate the effect of Bacillus Calmette-Guérin (BCG) instillation and radical cystectomy on high-risk NMIBC with squamous or glandular variants. We retrospectively reviewed the data of high-risk (T1 or CIS or HG or TaG1/G2 with multiple, recurrent, large tumor) NMIBC patients from January 2000 to December 2017. Comparative analysis of radical cystectomy, intravesical BCG, and observation groups was conducted in high-risk NMIBC with squamous or glandular histologic variants. Among the 1263 high-risk NMIBC patient, 62 (4.9%) were reported squamous or glandular histologic variants. Thirty patients underwent BCG instillation and 15 patients were subjected to radical cystectomy. Statistically significant differences were found between the three treatment groups in terms of underlying hypertension (p = 0.031), T stage (p = 0.022) and tumor multiplicity (p = 0.019). Similar 5-year OS (p = 0.893) and CSS (p = 0.811) were observed in each of BCG instillation and radical cystectomy group. BCG instillation showed survival benefit in both OS (p = 0.019) and CSS (p = 0.038) than in the observation group. In high-risk patients diagnosed with NMIBC bladder cancer with squamous or glandular histologic variants, both intravesical BCG and radical cystectomy showed survival gain. In conclusion, BCG instillation represents an appropriate treatment option in high-risk NMIBC with squamous or glandular histologic variant.

scholarly journals A Case of Acquired Rifampin Resistance inMycobacterium bovisBacillus Calmette-Guérin-Induced Cystitis: Necessity for Treatment Guidelines

2006 ◽  
Vol 17 (3) ◽  
pp. 183-185 ◽  
Author(s):  
Joyce N Wolfe ◽  
Kym S Blackwood-Antonation ◽  
Meenu K Sharma ◽  
Victoria J Cook
Keyword(s):  
Drug Resistance ◽  
Target Gene ◽  
Treatment Guidelines ◽  
Transitional Cell ◽  
Bacillus Calmette Guerin ◽  
Acquired Drug Resistance ◽  
Elderly Female ◽  
Intravesical Bcg ◽  
Rifampin Resistance ◽  
Bcg Instillation

A case of presumed bacillus Calmette-Guérin (BCG) cystitis in an elderly female patient following direct intravesical BCG instillation treatment for papillary transitional cell carcinoma is reported. The organism cultured from urine samples was eventually identified as a rifampin-resistantMycobacterium bovisBCG isolate. Because the patient had received rifampin monotherapy during the course of treatment for presumed BCG disease, the clinical picture favoured acquired rifampin resistance. Sequencing of the target gene for rifampin (rpoB) confirmed a known mutation responsible for conferring high levels of resistance to both rifampin and rifabutin (Ser531Tyr). To the authors' knowledge, this is the first reported case ofM bovisBCG disease in a non-HIV patient where the organism had acquired drug resistance to rifampin, and the second reported case ofM bovisBCG that had acquired drug resistance. The present case demonstrates the necessity to re-evaluate appropriate guidelines for the effective treatment of BCG disease.

scholarly journals Septic Shock after Intravesical BCG Instillation—A Case Report

2013 ◽  
Vol 03 (04) ◽  
pp. 243-247 ◽  
Author(s):  
Cristóvão Figueiredo ◽  
Diana Póvoas ◽  
Carlos Alves ◽  
Alcina Ferreira ◽  
Paulo Figueiredo ◽  
...  
Keyword(s):  
Septic Shock ◽  
Case Report ◽  
Intravesical Bcg ◽  
Bcg Instillation

PDT combined with Intravesical BCG instillation would form an autovaccine for bladder cancer?

2009 ◽  
Vol 73 (4) ◽  
pp. 559-560 ◽  
Author(s):  
HuiXuan Pan ◽  
Xiaopeng Ma ◽  
JunZhang Chen ◽  
Hong Jiang
Keyword(s):  
Bladder Cancer ◽  
Intravesical Bcg ◽  
Bcg Instillation

scholarly journals BCG Sepsis After Intravesical BCG Instillation: A Case Report

2019 ◽  
Vol 24 (1) ◽  
pp. 63-66 ◽  
Author(s):  
Meliha Çağla Sönmezer ◽  
Şükran Sevim ◽  
Necla Tülek ◽  
Esra Kaya ◽  
F. Şebnem Erdinç
Keyword(s):  
Case Report ◽  
Intravesical Bcg ◽  
Bcg Instillation
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