Transparent CuInS2 PMMA Nanocomposites Luminescent in the Visible and NIR Region

2014 ◽  
Vol 69 (2) ◽  
pp. 217-223 ◽  
Author(s):  
Krzysztof Guguła ◽  
Michael Bredol
Keyword(s):  
Optical Properties ◽  
Near Infrared ◽  
Deep Penetration ◽  
Ambient Conditions ◽  
White Leds ◽  
Functional Nanoparticles ◽  
Potential Applications ◽  
In Vivo Diagnostics ◽  
Transparent Polymers

Nanocomposites combining functional nanoparticles and transparent polymers allow for stabilization of filler properties over long periods of time while retaining transparency of the polymer matrix. Here we employ CuInS2/ZnS quantum dots (QDs), ternary visible- and NIR-emitting semiconductors as wavelength-tunable luminescent fillers. Luminescence in the near infrared (NIR) is of particular interest in medicine which allows deep penetration into human tissue enabling in vivo diagnostics and treatment, while visible emitters may serve as color converters in displays or lighting. To stabilize the optical properties of QDs and prevent agglomeration, polymethyl metacrylate (PMMA) was chosen as a matrix. These novel polymer nanocomposites (PNCs) show good optical properties and stability under ambient conditions, and can be easily deposited over large areas. High-quality QDs and hydrophobic functionalization with long-chain hydrocarbons are a prerequisite for embedding into a PMMA matrix. Transparent PNC films without visible scattering losses were obtained for 1 wt-% QD loading with respect to the polymer. Partial transparency is retained up to 10 wt-% QD loading and vanishes rapidly at higher loading. Luminescence properties increase up to 5 wt-% and then decrease rapidly due to QD agglomeration and reabsorption between adjacent particles. Potential applications include converter materials for medical applications, laser layers, displays and white LEDs.

scholarly journals Novel concept of the smart NIR-light–controlled drug release of black phosphorus nanostructure for cancer therapy

2018 ◽  
Vol 115 (3) ◽  
pp. 501-506 ◽  
Author(s):  
Meng Qiu ◽  
Dou Wang ◽  
Weiyuan Liang ◽  
Liping Liu ◽  
Yin Zhang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Drug Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Near Infrared ◽  
Black Phosphorus ◽  
Deep Penetration ◽  
Nir Light

A biodegradable drug delivery system (DDS) is one the most promising therapeutic strategies for cancer therapy. Here, we propose a unique concept of light activation of black phosphorus (BP) at hydrogel nanostructures for cancer therapy. A photosensitizer converts light into heat that softens and melts drug-loaded hydrogel-based nanostructures. Drug release rates can be accurately controlled by light intensity, exposure duration, BP concentration, and hydrogel composition. Owing to sufficiently deep penetration of near-infrared (NIR) light through tissues, our BP-based system shows high therapeutic efficacy for treatment of s.c. cancers. Importantly, our drug delivery system is completely harmless and degradable in vivo. Together, our work proposes a unique concept for precision cancer therapy by external light excitation to release cancer drugs. If these findings are successfully translated into the clinic, millions of patients with cancer will benefit from our work.

scholarly journals Multi-layered tissue head phantoms for noninvasive optical diagnostics

2015 ◽  
Vol 08 (03) ◽  
pp. 1541005 ◽  
Author(s):  
M. S. Wróbel ◽  
A. P. Popov ◽  
A. V. Bykov ◽  
M. Kinnunen ◽  
M. Jędrzejewska-Szczerska ◽  
...  
Keyword(s):  
Optical Properties ◽  
Near Infrared ◽  
Optical Measurement ◽  
Human Head ◽  
Medical Diagnostics ◽  
Optical Parameters ◽  
Measurement Systems ◽  
Tissue Phantoms ◽  
Optical And Mechanical Properties

Extensive research in the area of optical sensing for medical diagnostics requires development of tissue phantoms with optical properties similar to those of living human tissues. Development and improvement of in vivo optical measurement systems requires the use of stable tissue phantoms with known characteristics, which are mainly used for calibration of such systems and testing their performance over time. Optical and mechanical properties of phantoms depend on their purpose. Nevertheless, they must accurately simulate specific tissues they are supposed to mimic. Many tissues and organs including head possess a multi-layered structure, with specific optical properties of each layer. However, such a structure is not always addressed in the present-day phantoms. In this paper, we focus on the development of a plain-parallel multi-layered phantom with optical properties (reduced scattering coefficient [Formula: see text] and absorption coefficient μa) corresponding to the human head layers, such as skin, skull, and gray and white matter of the brain tissue. The phantom is intended for use in noninvasive diffuse near-infrared spectroscopy (NIRS) of human brain. Optical parameters of the fabricated phantoms are reconstructed using spectrophotometry and inverse adding-doubling calculation method. The results show that polyvinyl chloride-plastisol (PVCP) and zinc oxide ( ZnO ) nanoparticles are suitable materials for fabrication of tissue mimicking phantoms with controlled scattering properties. Good matching was found between optical properties of phantoms and the corresponding values found in the literature.

Stable Twisted Conformation Aza-BODIPY NIR-II Fluorescent Nanoparticles with Ultra-large Stokes Shift for Imaging-Guided Phototherapy

2022 ◽  
Author(s):  
Youliang Tian ◽  
Huiting Zhou ◽  
Quan Cheng ◽  
Huiping Dang ◽  
Hongyun Qian ◽  
...  
Keyword(s):  
Fluorescence Imaging ◽  
In Vivo Imaging ◽  
Near Infrared ◽  
Stokes Shift ◽  
Great Promise ◽  
Deep Penetration ◽  
Fluorescent Nanoparticles ◽  
Spatiotemporal Resolution ◽  
Large Stokes Shift

Fluorescence imaging in the second near-infrared window (NIR-II, 1000–1700 nm) holds great promise for in vivo imaging and imaging-guided phototherapy with deep penetration and high spatiotemporal resolution. It is very...

Influence of Blood Glucose Level on the Scattering Coefficient of the Skin in Near-Infrared Spectroscopy

2011 ◽  
Author(s):  
Sachiko Kessoku ◽  
Katsuhiko Maruo ◽  
Shinpei Okawa ◽  
Kazuto Masamoto ◽  
Yukio Yamada
Keyword(s):  
Optical Properties ◽  
Infrared Spectroscopy ◽  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Near Infrared Spectroscopy ◽  
Near Infrared ◽  
Monitoring Methods ◽  
Absorbance Spectra

Various non-invasive glucose monitoring methods using near-infrared spectroscopy have been investigated although no method has been successful so far. Our previous study has proposed a new promising method utilizing numerically generated absorbance spectra instead of the experimentally acquired absorbance spectra. The method suggests that the correct estimation of the optical properties is very important for numerically generating the absorbance spectra. The purpose of this study is to measure the change in the optical properties of the skin with the change in the blood glucose level in vivo. By measuring the reflectances of light incident on the skin surface at two distances from the incident point, the optical properties of the skin can be estimated. The estimation is a kind of the inverse problem based on the simulation of light propagation in the skin. Phantom experiments have verified the method and in vivo experiments are to be performed.

Synthesis and optical properties of emission-tunable PbS/CdS core–shell quantum dots for in vivo fluorescence imaging in the second near-infrared window

RSC Advances ◽  
2014 ◽  
Vol 4 (77) ◽  
pp. 41164-41171 ◽  
Author(s):  
Yoshikazu Tsukasaki ◽  
Masatoshi Morimatsu ◽  
Goro Nishimura ◽  
Takao Sakata ◽  
Hidehiro Yasuda ◽  
...  
Keyword(s):  
Quantum Dots ◽  
Optical Properties ◽  
Fluorescence Imaging ◽  
Near Infrared ◽  
Core Shell ◽  
Cds Quantum Dots ◽  
In Vivo Fluorescence ◽  
In Vivo Fluorescence Imaging ◽  
Infrared Window

This paper describes the synthesis and optical properties of PbS/CdS quantum dots for in vivo fluorescence imaging.

scholarly journals Optical investigation of bovine grey and white matters in visible and near-infrared ranges

2021 ◽  
Vol 27 (1) ◽  
pp. 99-107
Author(s):  
Ali Shahin ◽  
Wesam Bachir ◽  
Moustafa Sayem El-Daher
Keyword(s):  
Optical Properties ◽  
Absorption Coefficient ◽  
Wavelength Range ◽  
Grey Matter ◽  
Near Infrared ◽  
Biological Tissues ◽  
Integrating Sphere ◽  
Visible Range ◽  
Optical Investigation

Abstract Introduction: Due to enormous interests for laser in medicine and biology, optical properties characterization of different tissue have be affecting in development processes. In addition, the optical properties of biological tissues could be influenced by storage methods. Thus, optical properties of bovine white and grey tissues preserved by formalin have been characterized over a wide wavelength spectrum varied between 440 nm and 1000 nm. Materials and Methods: To that end, a single integrating sphere system was assembled for spectroscopic characterization and an inverse adding-doubling algorithm was used to retrieve optical coefficients, i.e. reduced scattering and absorption coefficients. Results: White matter has shown a strong scattering property in comparison to grey matter. On the other hand, the grey matter has absorbed light extensively. In comparison, the reduced scattering profile for both tissue types turned out to be consistent with prior works that characterized optical coefficients in vivo. On the contrary, absorption coefficient behavior has a different feature. Conclusion: Formalin could change the tissue’s optical properties because of the alteration of tissue’s structure and components. The absence of hemoglobin that seeps out due to the use of a formalin could reduce the absorption coefficient over the visible range. Both the water replacement by formalin could reduce the refractive index of a stored tissue and the absence of hemoglobin that scatters light over the presented wavelength range should diminish the reduced scattering coefficients over that wavelength range.

scholarly journals Near-Infrared Fluorescent Sorbitol Probe for Targeted Photothermal Cancer Therapy

Cancers ◽  
2019 ◽  
Vol 11 (9) ◽  
pp. 1286 ◽  
Author(s):  
Lee ◽  
Jung ◽  
Jo ◽  
Yang ◽  
Koh ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Laser Irradiation ◽  
Near Infrared ◽  
Photothermal Effect ◽  
Great Promise ◽  
Targeted Cancer Therapy ◽  
Potential Applications ◽  
Photothermal Property ◽  
Nir Laser

Abstract: Photothermal therapy (PTT) using a near-infrared (NIR) heptamethine cyanine fluorophore has emerged as an alternative strategy for targeted cancer therapy. NIR fluorophores showing a high molar extinction coefficient and low fluorescence quantum yield have considerable potential applications in photothermal cancer therapy. In this study, a bifunctional sorbitol–ZW800 conjugate was used as an advanced concept of photothermal therapeutic agents for in vivo cancer imaging and therapy owing to the high tumor targetability of the sorbitol moiety and excellent photothermal property of NIR heptamethine cyanine fluorophore. The sorbitol–ZW800 showed an excellent photothermal effect increased by 58.7 °C after NIR laser irradiation (1.1 W/cm2) for 5 min. The HT-29 tumors targeted by sorbitol–ZW800 showed a significant decrease in tumor volumes for 7 days after photothermal treatment. Therefore, combining the bifunctional sorbitol–ZW800 conjugate and NIR laser irradiation is an alternative way for targeted cancer therapy, and this approach holds great promise as a safe and highly efficient NIR photothermal agent for future clinical applications.

Design of AIEgens for Near-Infrared IIb Imaging Through Structural Modulation at Molecular and Morphological Levels

2019 ◽  
Author(s):  
yuanyuan li ◽  
Zhaochong Cai ◽  
shunjie liu ◽  
Haoke Zhang ◽  
sherman Wong ◽  
...  
Keyword(s):  
Blood Vessels ◽  
Fluorescence Imaging ◽  
Near Infrared ◽  
Molecular Design ◽  
Organic Dyes ◽  
Tissue Imaging ◽  
Deep Penetration ◽  
Structural Modulation ◽  
Organic Fluorophore

<p>Fluorescence imaging in near-infrared IIb (NIR-IIb, 1500-1700 nm) spectrum holds a considerable promise for tissue imaging with deep penetration and high spatial resolution owing to the minimized autofluorescence and suppressed photon scattering. While few inorganic NIR-IIb fluorescent probes have been reported, their organic counterparts are still underdeveloped, possibly due to the lack of efficient materials with long emission wavelength. Herein, we propose a new molecular design philosophy to develop organic NIR-IIb fluorophores with high quantum yield (QY) by manipulation of the effects of twisted intramolecular charge transfer and aggregation-induced emission at the molecular and morphological levels. A pure organic fluorescent dye emitting up to 1600 nm with a QY of 14.2% in the NIR-II region (1000-1600 nm) is developed. For the first time, NIR-IIb fluorescence imaging of blood vessels and deeply-located intestinal tract of live mice based on organic dyes is achieved. The results show that organic fluorophore performs superb imaging ability in both superficial blood vessels and internal organs with high resolution and enhanced signal-to-background ratio in NIR-IIb region. We hope this groundbreakingly study will inspire further research on the evolution of pure organic NIR-IIb probes for in vivo imaging.</p>

scholarly journals Melanin-dot–mediated delivery of metallacycle for NIR-II/photoacoustic dual-modal imaging-guided chemo-photothermal synergistic therapy

2019 ◽  
Vol 116 (34) ◽  
pp. 16729-16735 ◽  
Author(s):  
Yue Sun ◽  
Feng Ding ◽  
Zhao Chen ◽  
Ruiping Zhang ◽  
Chonglu Li ◽  
...  
Keyword(s):  
Near Infrared ◽  
High Efficiency ◽  
Photoacoustic Imaging ◽  
Photoacoustic Signal ◽  
Single Treatment ◽  
Good Solubility ◽  
Potential Applications ◽  
Good Signal ◽  
Infrared Channel

Discrete Pt(II) metallacycles have potential applications in biomedicine. Herein, we engineered a dual-modal imaging and chemo-photothermal therapeutic nano-agent 1 that incorporates discrete Pt(II) metallacycle 2 and fluorescent dye 3 (emission wavelength in the second near-infrared channel [NIR-II]) into multifunctional melanin dots with photoacoustic signal and photothermal features. Nano-agent 1 has a good solubility, biocompatibility, and stability in vivo. Both photoacoustic imaging and NIR-II imaging in vivo confirmed that 1 can effectively accumulate at tumor sites with good signal-to-background ratio and favorable distribution. Guided by precise dual-modal imaging, nano-agent 1 exhibits a superior antitumor performance and less severe side effects compared with a single treatment because of the high efficiency of the chemo-photothermal synergistic therapy. This study shows that nano-agent 1 provides a promising multifunctional theranostic platform for potential applications in biomedicine.

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