scholarly journals Risk Factors of Atherosclerotic Diseases - Executive Summary of Japan Atherosclerosis Society (JAS) Guideline for Diagnosis and Prevention of Atherosclerotic Cardiovascular Diseases for Japanese

2007 ◽  
Vol 14 (6) ◽  
pp. 267-277 ◽  
Author(s):  
Tamio Teramoto ◽  
Jun Sasaki ◽  
Hirotsugu Ueshima ◽  
Genshi Egusa ◽  
Makoto Kinoshita ◽  
...  
2005 ◽  
Vol 81 (6) ◽  
pp. 447-453 ◽  
Author(s):  
Roya Kelishadi ◽  
Gholamhossein Sadri ◽  
Ali Akbar Tavasoli ◽  
Manijeh Kahbazi ◽  
Hamid Reza Roohafza ◽  
...  

Author(s):  
Prem S. Singh ◽  
K. S. Zafar ◽  
Manoj Kumar ◽  
Sudhir K. Yadav

Background: Incidence and prevalence of diabetes is on surge day by day and increased longevity of diabetic patients put them at higher risk of chronic complications of hyperglycemia. Of these complications, atherosclerotic cardiovascular diseases (CVD) are of utmost importance and atherosclerotic cardiovascular diseases are the major cause of premature mortality in patients with type 2 diabetes as well. Regional variation of risk factors and sociocultural diversity of Indian population create a significant difference in atherosclerotic risk among the diabetic population across the country. There is a significant gap in the knowledge of CVD epidemiology and associated risk factors among the Indian population especially among the rural population. The objective of this study was to assess cardiovascular risk among diabetic patients of rural central India.Methods: The present cross-sectional study included 160 diabetic patients (78 males and 82 females) aged 35–75 years from the villages of district Etawah of UP, Central India. Sex-specific Framingham general cardiovascular risk prediction equations were used to calculate the 10years risk for cardiovascular disease. The probable risk factors were determined by cross-tabulation of cardiometabolic parameters with the 10-year cardiovascular risk level.Results: Males were found to be at higher risk of developing CVD in the future as compared to females with a discernible accumulation of adverse cardiovascular risk factors among them. 38.75% patients were at high risk, 37.50% at moderate risk and 23.75% at low risk for developing CVD in the next 10 years. Systolic blood pressure, total cholesterol, triglyceride and smoking contributed significantly to high degree of cardiovascular risk. Presence of cardiovascular risk factors among diabetic patients at diagnosis accentuates the need of intensive management of cardiovascular complications taking into consideration the traditional dietary pattern of the rural population.Conclusions: Both diabetes and CVD have common genetic and environmental antecedents. Furthermore, insulin resistance preceding long before the diagnosis of diabetes enhances atherogenic risk profile and has been delineated as a potential cause for subsequent increased risk of CVD among diabetic patients. There is need of intensive management of cardiovascular risk factors among diabetic individuals. Therefore, there is a need of a comprehensive study design which includes various factors (biological, sociodemographic and genetic) which directly or indirectly influence the disease incidence especially in a country (India) with diverse ethnic population.


2021 ◽  
Vol 10 (12) ◽  
pp. 2539
Author(s):  
Piotr Szwed ◽  
Aleksandra Gąsecka ◽  
Mateusz Zawadka ◽  
Ceren Eyileten ◽  
Marek Postuła ◽  
...  

Atherosclerotic cardiovascular diseases (ASCVD) are the major cause of mortality worldwide. Despite the continuous progress in ASCVD therapy, the residual risk persists beyond the management of traditional risk factors. Several infections including Helicobacter pylori infection, periodontal disease, and viral infections are associated with the increased risk of ASCVD, both directly by damage to the heart muscle and vasculature, and indirectly by triggering a systemic proinflammatory state. Hence, beyond the optimal management of the traditional ASCVD risk factors, infections should be considered as an important non-classical risk factor to enable early diagnosis and appropriate treatment. Here, we summarized the currently available evidence regarding the role of inflammation in ASCVD and the association between the particular infections and pathogens (Helicobacter pylori, periodontal disease, pneumonia, Cytomegalovirus, Human immunodeficiency virus, Herpes simplex virus, and severe acute respiratory syndrome coronavirus 2) on the development and progression of ASCVD. We also speculated about the potential therapeutic implications of the anti-inflammatory and anti-infective drugs on ASCVD outcomes, including drugs routinely administered in patients with ASCVD (statins, P2Y12 receptor inhibitors, and angiotensin-converting enzyme inhibitors/angiotensin receptor blockers) and novel strategies aiming at residual risk reduction (colchicine, anti-cytokine drugs, and methotrexate). Considering the emerging association between infections and ASCVD, it is crucial to determine the possible advantages of infection prevention and treatment in patients with ASCVD.


2018 ◽  
Vol 3 (3) ◽  
pp. 39-46
Author(s):  
OV V Fatenkov ◽  
VV V Simerzin ◽  
IV V Gagloeva ◽  
MA A Galkina ◽  
YaA A Panisheva ◽  
...  

This survey presents the role of endothelial dysfunction in pathogenesis of atherosclerotic cardiovascular diseases as predictor of their development. Leading risk factors of endothelial dysfunction and methods of its diagnostics are also shown. Special attention is given to non medicamental correction of endothelial function disorders and its pharmacotherapy with statins, inhibitors of angiotensin converting enzyme (ACE), calcium antagonists and other drugs.


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