Cumulative prevalence of risk factors for atherosclerotic cardiovascular diseases in Iranian adolescents: IHHP-HHPC

2005 ◽  
Vol 81 (6) ◽  
pp. 447-453 ◽  
Author(s):  
Roya Kelishadi ◽  
Gholamhossein Sadri ◽  
Ali Akbar Tavasoli ◽  
Manijeh Kahbazi ◽  
Hamid Reza Roohafza ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Diseases ◽  
Atherosclerotic Cardiovascular Diseases ◽  
Cumulative Prevalence

scholarly journals Risk of cardiovascular disease among diabetic patients in rural population of Central India

2017 ◽  
Vol 5 (4) ◽  
pp. 1563
Author(s):  
Prem S. Singh ◽  
K. S. Zafar ◽  
Manoj Kumar ◽  
Sudhir K. Yadav
Keyword(s):  
Risk Factors ◽  
Cardiovascular Disease ◽  
Cardiovascular Risk ◽  
Cardiovascular Diseases ◽  
Cardiovascular Risk Factors ◽  
Indian Population ◽  
Central India ◽  
Diabetic Patients ◽  
Intensive Management ◽  
Atherosclerotic Cardiovascular Diseases

Background: Incidence and prevalence of diabetes is on surge day by day and increased longevity of diabetic patients put them at higher risk of chronic complications of hyperglycemia. Of these complications, atherosclerotic cardiovascular diseases (CVD) are of utmost importance and atherosclerotic cardiovascular diseases are the major cause of premature mortality in patients with type 2 diabetes as well. Regional variation of risk factors and sociocultural diversity of Indian population create a significant difference in atherosclerotic risk among the diabetic population across the country. There is a significant gap in the knowledge of CVD epidemiology and associated risk factors among the Indian population especially among the rural population. The objective of this study was to assess cardiovascular risk among diabetic patients of rural central India.Methods: The present cross-sectional study included 160 diabetic patients (78 males and 82 females) aged 35–75 years from the villages of district Etawah of UP, Central India. Sex-specific Framingham general cardiovascular risk prediction equations were used to calculate the 10years risk for cardiovascular disease. The probable risk factors were determined by cross-tabulation of cardiometabolic parameters with the 10-year cardiovascular risk level.Results: Males were found to be at higher risk of developing CVD in the future as compared to females with a discernible accumulation of adverse cardiovascular risk factors among them. 38.75% patients were at high risk, 37.50% at moderate risk and 23.75% at low risk for developing CVD in the next 10 years. Systolic blood pressure, total cholesterol, triglyceride and smoking contributed significantly to high degree of cardiovascular risk. Presence of cardiovascular risk factors among diabetic patients at diagnosis accentuates the need of intensive management of cardiovascular complications taking into consideration the traditional dietary pattern of the rural population.Conclusions: Both diabetes and CVD have common genetic and environmental antecedents. Furthermore, insulin resistance preceding long before the diagnosis of diabetes enhances atherogenic risk profile and has been delineated as a potential cause for subsequent increased risk of CVD among diabetic patients. There is need of intensive management of cardiovascular risk factors among diabetic individuals. Therefore, there is a need of a comprehensive study design which includes various factors (biological, sociodemographic and genetic) which directly or indirectly influence the disease incidence especially in a country (India) with diverse ethnic population.

scholarly journals Infections as Novel Risk Factors of Atherosclerotic Cardiovascular Diseases: Pathophysiological Links and Therapeutic Implications

2021 ◽  
Vol 10 (12) ◽  
pp. 2539
Author(s):  
Piotr Szwed ◽  
Aleksandra Gąsecka ◽  
Mateusz Zawadka ◽  
Ceren Eyileten ◽  
Marek Postuła ◽  
...  
Keyword(s):  
Risk Factors ◽  
Helicobacter Pylori ◽  
Cardiovascular Diseases ◽  
Periodontal Disease ◽  
Angiotensin Receptor Blockers ◽  
Residual Risk ◽  
Converting Enzyme Inhibitors ◽  
Therapeutic Implications ◽  
Increased Risk ◽  
Atherosclerotic Cardiovascular Diseases

Atherosclerotic cardiovascular diseases (ASCVD) are the major cause of mortality worldwide. Despite the continuous progress in ASCVD therapy, the residual risk persists beyond the management of traditional risk factors. Several infections including Helicobacter pylori infection, periodontal disease, and viral infections are associated with the increased risk of ASCVD, both directly by damage to the heart muscle and vasculature, and indirectly by triggering a systemic proinflammatory state. Hence, beyond the optimal management of the traditional ASCVD risk factors, infections should be considered as an important non-classical risk factor to enable early diagnosis and appropriate treatment. Here, we summarized the currently available evidence regarding the role of inflammation in ASCVD and the association between the particular infections and pathogens (Helicobacter pylori, periodontal disease, pneumonia, Cytomegalovirus, Human immunodeficiency virus, Herpes simplex virus, and severe acute respiratory syndrome coronavirus 2) on the development and progression of ASCVD. We also speculated about the potential therapeutic implications of the anti-inflammatory and anti-infective drugs on ASCVD outcomes, including drugs routinely administered in patients with ASCVD (statins, P2Y12 receptor inhibitors, and angiotensin-converting enzyme inhibitors/angiotensin receptor blockers) and novel strategies aiming at residual risk reduction (colchicine, anti-cytokine drugs, and methotrexate). Considering the emerging association between infections and ASCVD, it is crucial to determine the possible advantages of infection prevention and treatment in patients with ASCVD.

scholarly journals ENDOTHELIAL DYSFUNCTION AS PREDICTOR OF SUBCLINICAL AND MANIFEST ATHEROSCLEROSIS

2018 ◽  
Vol 3 (3) ◽  
pp. 39-46
Author(s):  
OV V Fatenkov ◽  
VV V Simerzin ◽  
IV V Gagloeva ◽  
MA A Galkina ◽  
YaA A Panisheva ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Diseases ◽  
Endothelial Dysfunction ◽  
Angiotensin Converting Enzyme ◽  
Endothelial Function ◽  
Calcium Antagonists ◽  
Converting Enzyme ◽  
Atherosclerotic Cardiovascular Diseases

This survey presents the role of endothelial dysfunction in pathogenesis of atherosclerotic cardiovascular diseases as predictor of their development. Leading risk factors of endothelial dysfunction and methods of its diagnostics are also shown. Special attention is given to non medicamental correction of endothelial function disorders and its pharmacotherapy with statins, inhibitors of angiotensin converting enzyme (ACE), calcium antagonists and other drugs.

scholarly journals OSTEOPOROZ I SERDEChNO-SOSUDISTYE ZABOLEVANIYa (SSZ) OBUSLOVLENNYE ATEROSKLEROZOM (AS) U ZhENShchIN POSTMENOPAUZAL'NOGO PERIODA:OBShchNOST' POVEDENChESKIKh I SOTsIAL'NYKh FAKTOROV RISKA

2009 ◽  
Vol 12 (2) ◽  
pp. 5-9 ◽  
Author(s):  
I A Skripnikova ◽  
R G Oganov
Keyword(s):  
Risk Factors ◽  
Cardiovascular Diseases ◽  
Reproductive Function ◽  
The Body ◽  
Way Of Life ◽  
Public Health Services ◽  
The Social ◽  
Economic Injury ◽  
Atherosclerotic Cardiovascular Diseases ◽  
Further Development

It is spent prospective 15 years research on studying combined pathologies (the atherosclerotic cardiovascular diseases and osteoporosis) and the general risk factors of these diseases in women at transition from reproductive in postmenopausal period. It has been shown, that the combination the atherosclerotic cardiovascular diseases and osteoporosis at postmenopausal women meets in 8 % of cases. Behavioural risk factors the atherosclerotic cardiovascular diseases, such as features ofa food, the body mass, an inactive way of life and smoking have integrated character, promoting development of both pathologies, however influence of these riskfactors on development the diseases a miscellaneous. The social status and reproductive function ofwomen make significant impact on formation of risk factors of cardiovascular diseases and osteoporosis. Timely revealing risk factors and influence on them can promote prevention both the atherosclerotic cardiovascular diseases and osteoporosis, to constrain the further development of these diseases and to reduce the economic injury put to public health services and the patient.

scholarly journals Relationship of obesity, low-density lipoprotein cholesterol and myocardial perfusion in patients with risk factors and without atherosclerotic cardiovascular diseases

2021 ◽  
Vol 20 (2) ◽  
Author(s):  
V. B. Sergienko ◽  
A. A. Ansheles ◽  
I. V. Sergienko ◽  
S. A. Boytsov
Keyword(s):  
Risk Factors ◽  
Cardiovascular Diseases ◽  
Myocardial Perfusion ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Low Density ◽  
Low Density Lipoprotein Cholesterol ◽  
Atherosclerotic Cardiovascular Diseases ◽  
The Relationship ◽  
Rest Myocardial Perfusion

Aim. In the retrospective study, to identify the relationship between body mass index (BMI), low-density lipoprotein cholesterol (LDL-C) levels and myocardial perfusion in patients without established atherosclerotic cardiovascular diseases.Material and methods. The study included 534 patients with cardiovascular risk factors but without established coronary artery disease, diabetes, myocardial infarction or coronary revascularization. In 76 of them, stress/rest myocardial perfusion single-photon emission computed tomography (SPECT) was performed.Results. The relationship between BMI and LDL-C levels is described by a quadratic (r2=0,21, p<0,001) function or a linear spline kinked in BMI of 27 kg/m2 (r=0,51, -0,46 — before and after this value, respectively; p<0,001). According to SPECT, focal stable and transient left ventricular myocardial perfusion abnormalities were not detected. However, there was a direct linear correlation between the heterogeneity of rest myocardial perfusion (ohet) and BMI (r=0,43, p<0,001), ohet and waist circumference (r=0,40, p<0,001), as well as between ohet and LDL-C (r=0,44, p<0,001).Conclusion. The relationship between BMI and LDL-C levels can be explained by endocrine dysfunction of adipose tissue, which disturbs the synthesis and metabolism of atherogenic lipoproteins. Obesity and increased LDL-C levels affect myocardial perfusion both by aggravating coronary atherogenesis and by microcirculatory disorders. Rest myocardial perfusion SPECT can be a method of screening for myocardial disorders caused by both diffuse atherosclerosis and metabolic syndrome.

Apolipoprotein(a), Fibrinopeptide A and Carotid Atherosclerosis in Middle-Aged Men

1994 ◽  
Vol 72 (04) ◽  
pp. 563-566 ◽  
Author(s):  
Tuomo Rankinen ◽  
Sari Väisänen ◽  
Michele Mercuri ◽  
Rainer Rauramaa
Keyword(s):  
Risk Factors ◽  
Cardiovascular Diseases ◽  
Carotid Atherosclerosis ◽  
Intima Media Thickness ◽  
Carotid Bifurcation ◽  
Carotid Intima Media Thickness ◽  
Fibrinopeptide A ◽  
Carotid Imt ◽  
Apolipoprotein A ◽  
The Difference

SummaryThe association between apolipoprotein(a) [apo(a)], fibrinogen, fibrinopeptide A (FPA) and carotid intima-media thickness (IMT) was analyzed in Eastern Finnish men aged 50 to 60 years. Apo(a) correlated directly with carotid bifurcation (r = 0.26, p = 0.001), but not with common carotid IMT. Men in the lowest quartile of apo(a) had thinner (p = 0.013) IMT in bifurcation [1.59 mm (95% Cl 1.49; 1.68)] compared to the men in the highest [1.91 mm (95% Cl 1.73; 2.09)] apo(a) quartile. The difference remained (p=0.038) after adjusting for confounders. Plasma fibrinogen was not related to carotid IMT, whereas FPA correlated with common carotid (r = 0.21, p = 0.016) and carotid bifurcation (r = 0.21, p = 0.018) IMT. These associations abolished after adjusting for the confounders. The data suggest that apo(a) associate with carotid atherosclerosis independent of other risk factors for ischemic cardiovascular diseases.

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