scholarly journals Influence of Drought Stress on Oxidative Damage and Antioxidant Defense Systems in Tolerant and Susceptible Wheat Genotypes

2012 ◽  
Vol 4 (8) ◽  
Author(s):  
Hojjat Hasheminasab ◽  
Mohammad Taghi Assad ◽  
Ali Aliakbari ◽  
Seyyed Rasoul Sahhafi
Keyword(s):  
Drought Stress ◽  
Oxidative Damage ◽  
Antioxidant Defense ◽  
Wheat Genotypes ◽  
Defense Systems ◽  
Antioxidant Defense Systems

scholarly journals Physıologıcal response of Apocynum venetum L. seedlıngs under osmotıc stress

2018 ◽  
Vol 44 (4) ◽  
pp. 551-556
Author(s):  
Hua Zhao ◽  
Huiping Dai
Keyword(s):  
Superoxide Dismutase ◽  
Polyethylene Glycol ◽  
Drought Stress ◽  
Physiological Response ◽  
Antioxidant Defense ◽  
Soluble Sugar ◽  
Defense Systems ◽  
Apocynum Venetum ◽  
Antioxidant Defense Systems ◽  
Effects Of Drought

Effects of drought stress were induced by polyethylene glycol (PEG-6000) (10, 20, and 30% ) for 2, 4, 6 and 8 days in Apocynum venetum L. seedlings with the potting method. The results showed that PEG significantly increased the activities of glutathione reductase (GR), superoxide dismutase (SOD), ascorbate peroxidase (APX), and the contents of electrolyte leakage rates, MDA, proline and soluble sugar were increased from 30% PEG. Thus, it was indicated that the application of exogenous 30% PEG induced oxidative damage by enhancing antioxidant defense systems.

scholarly journals Mitoubiquinol Mesylate Attenuated Diethyl Nitrosamine–Induced Hepatocellular Carcinoma Through Modulation of Mitochondrial Antioxidant Defense Systems

2020 ◽  
Vol 6 (Supplement_1) ◽  
pp. 9-9
Author(s):  
Adisa Rahmat Adetutu ◽  
Sulaimon Lateef Adegboyega ◽  
Okeke Ebele Geraldine ◽  
Ariyo OC ◽  
Abdulkareem Fatimah Biade
Keyword(s):  
Oxidative Stress ◽  
Hepatocellular Carcinoma ◽  
Liver Function ◽  
Oxidative Damage ◽  
Wistar Rats ◽  
Antioxidant Defense ◽  
Tumor Incidence ◽  
Defense Systems ◽  
Significant Difference ◽  
Antioxidant Defense Systems

PURPOSE Hepatocellular carcinoma (HCC) is a highly malignant cancer, with a high recurrence rate and a poor prognosis. Diethyl nitrosamine (DEN) cirrhosis HCC–induced model has revealed an association of cancer progression with oxidative stress and mitochondrial dysfunction. This study investigated the effects of mitoubiquinol mesylate (MitoQ), a mitochondrial targeted antioxidant derivative from ubiquinone on DEN-induced oxidative damage in HCC Wistar rats. METHODS Fifty male Wistar rats were randomly divided into 5 groups, 10 rats per group. Groups A, B, and C received distilled water 10 mL/kg DEN, and MitoQ orally for 16 weeks, respectively. Animals in group D were pretreated with MitoQ for 1 week followed by coadministration of MitoQ and DEN (protective effect), whereas group E received DEN for 8 weeks, then coadministration of DEN and MitoQ (therapeutic effect) until the end of the study. Survival index, tumor incidence, liver function indices, hematologic profile, mitochondrial respiratory enzymes, and antioxidant defense status were assessed. RESULTS Data obtained show that rats in groups D and E had 80% survival and decreased tumor incidence (40% and 60%, respectively) compared with group B. Similarly, MitoQ significantly ( P < .05) decreased the activities of liver function enzymes, while hemoglobin concentration, red blood cell count, and lymphocytes levels were significantly elevated compared with the DEN-only group. Furthermore, MitoQ significantly ( P < .05) protected the liver from DEN-induced oxidative damage; however, there was no significant difference ( P > .05) between activities of mitochondrial F1F0-ATPase and succinate dehydrogenase of groups A, B, D, and E, respectively, although these enzyme activities were significantly ( P < .05) elevated in group C. Macroscopic and microscopic features indicated a reversal of DEN-induced cellular degeneration in hepatocytes. CONCLUSION These data suggest that MitoQ treatment for 16 weeks attenuated DEN-induced oxidative stress indices via modulation of mitochondrial antioxidant defense systems and could alleviate the burden of HCC as a chemotherapeutic agent.

Antioxidant Defense Systems

2021 ◽  
pp. 94-143
Author(s):  
Carmen Cecilia Espíndola Díaz
Keyword(s):  
Antioxidant Defense ◽  
Defense Systems ◽  
Antioxidant Defense Systems
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