scholarly journals Maltase Inhibitory Activity of Aqueous Extracts of Zingiber officinale Rosc. and Trigonella foenum-graecum Linn.

2018 ◽  
Vol 10 (2) ◽  
pp. 226-229
Author(s):  
Janhavi Jatin Daman ◽  
Radiya Pacha-Gupta ◽  
Nandita Mangalore
Keyword(s):  
Inhibitory Activity ◽  
Zingiber Officinale ◽  
Aqueous Extracts ◽  
Trigonella Foenum Graecum

scholarly journals Screening of Protease Inhibitory Activity in Aqueous Extracts of Marine Invertebrates from Cuban Coast

2016 ◽  
Vol 07 (04) ◽  
pp. 319-331 ◽  
Author(s):  
Lidice González ◽  
Rafael E. Sánchez ◽  
Laritza Rojas ◽  
Isel Pascual ◽  
Rossana García-Fernández ◽  
...  
Keyword(s):  
Inhibitory Activity ◽  
Marine Invertebrates ◽  
Aqueous Extracts ◽  
Protease Inhibitory Activity

scholarly journals Diyabette Kullanılan Bitkisel Desteklerin Etkinliği ve Güvenilirliği

2019 ◽  
Vol 47 ◽  
pp. 110-117
Author(s):  
Ezgi Bellikci Koyu
Keyword(s):  
Nigella Sativa ◽  
Zingiber Officinale ◽  
Urtica Dioica ◽  
Momordica Charantia ◽  
Trigonella Foenum Graecum ◽  
Zingiber Officinale Roscoe ◽  
Trigonella Foenum Graecum L

Bitkiler uzun yüzyıllar boyunca tedavinin en önemli parçası olmuşlardır. On dokuzuncu yüzyılda kimya alanında önemli gelişmelerin olması ve ilaç moleküllerinin keşfi ile bitkilerin tıbbi amaçlı kullanımları giderek azalsa da, son yıllarda doğaya dönüş çabaları içerisinde kullanımlarında yeniden bir artış gözlenmektedir. Özellikle diyabet gibi kronik seyirli hastalıklarda modern tedaviye destek olarak bu ürünlerin kullanımları sıklıkla tercih edilmektedir. Bu ilgiye paralel olarak son yıllarda bitkilerin diyabet tedavisindeki etkisini araştıran klinik çalışmalar da artmaya başlamıştır. Etkinliğin yanı sıra bitkilerin güvenilir kullanımları da son derece önemlidir. Doğru bitkinin kullanımı, kullanılan ürünün bileşimi, kalitesi, hazırlama yöntemi, yan etkileri, ilaç etkileşimleri ve kontraendikasyonları da tedavi sürecini etkileyen ve güvenilir kullanım için göz önünde bulundurulması gereken faktörlerdir. Bu derlemede tarçın (Cinnamomum sp.), çörek otu (Nigella sativa L.), kudret narı (Momordica charantia L.), çemen otu (Trigonella foenum-graecum L.), zencefil (Zingiber officinale Roscoe) ve ısırgan otu (Urtica dioica L.) gibi diyabet tedavisinde sıklıkla tercih edilen bitkilerin etkinliği ve güvenilirliği değerlendirilmiştir.

scholarly journals Shortlisting Phytochemicals Exhibiting Inhibitory Activity against Major Proteins of SARS-CoV-2 through Virtual Screening

2020 ◽  
Author(s):  
Saranya Nallusamy ◽  
Jayakanthan Mannu ◽  
Caroline Ravikumar ◽  
Kandavelmani Angamuthu ◽  
Bharathi Nathan ◽  
...  
Keyword(s):  
Virtual Screening ◽  
Inhibitory Activity ◽  
Mangifera Indica ◽  
Herbal Medicines ◽  
Genomic Analysis ◽  
Zingiber Officinale ◽  
Major Protein ◽  
Synthetic Drugs ◽  
Cissus Quadrangularis ◽  
Control And Management

Abstract Severe Acute Respiratory Syndrome Corona Virus 2 (SARS-CoV-2) declared as a pandemic by WHO that has affected more than 40 lakh peoples and caused death of more than 2 lakh individuals across the globe. Limited availability of genomic information of SARS-CoV-2 and non-availability of vaccines and effective drugs are major problems responsible for the ineffective control and management of this pandemic. Several attempts have been made to explore repurposing existing drugs known for their anti-viral activities, and test the traditional herbal medicines known for their health benefiting and immune boosting activity against SARS-CoV-2.In this study, efforts were made to examine the potential of 721 phytochemicals of 37 plant species in inhibiting major protein targets namely, spike glycoprotein, main protease (MPro), NSP3, NSP9, NSP15, NSP10-NSP16 and RNA dependent RNA polymerase of SARS-CoV-2 through virtual screening approach. Results of our experiments revealed that SARS-CoV-2 MPro shared significant dissimilarities against SARS-CoVMPro and MERS-CoVMPro indicating the need for discovering novel drugs. This study has identified the phytochemical cyanin (Zingiber officinale) exhibiting broad spectrum inhibitory activity against main proteases of all the three Coronaviruses. Amentoflavone, agathisflavone, catechin-7-o-gallate and chlorogeninwere shown to exhibit multi target inhibitory activity. This study has identified Mangifera indica, Anacardium occidentale, Vitex negundo, Solanum nigrum, Pedalium murex, Terminalia chebula, Azadirachta indica, Cissus quadrangularis, Clerodendrum serratum and Ocimum basilicum as potential sources of phytochemicals combating nCOVID-19. More interestingly, this study has generated evidences for the anti-viral properties of the traditional herbal formulation “Kabasura kudineer” recommended by AYUSH, a unit of Government of India. Testing of short listed phytochemicals through clinical trials will help in developing effective formulation for management of this pandemic disease. Genomic analysis of identified herbal plants will help in unravelling molecular complexity of therapeutic and anti-viral properties and will pave way for designing synthetic drugs.

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