scholarly journals Investigation of the Effects of Calcium Fructoborate on Testicular Structure in Rats within the Framework of Biochemical Parameters, Testosterone Hormone and DNA Damage in Cadmium Chloride Induced Toxicity

2021 ◽  
Vol 55 (2) ◽  
pp. 544-549
Author(s):  
Saadet Belhan ◽  
Ahmet Ufuk Komuroglu ◽  
Ugur Ozdek ◽  
Ali Sefa Mendil ◽  
Ali Rıza Kul ◽  
...  
Keyword(s):  
Dna Damage ◽  
Biochemical Parameters ◽  
Cadmium Chloride ◽  
Calcium Fructoborate

scholarly journals In Vivo Antioxidant And Kidney Protective Potential Of Atorvastatin In Rat Cadmium-Induced Toxicity

2021 ◽  
Author(s):  
Esmaeil Karami ◽  
Zahra Goodarzi ◽  
Ali Ghanbari ◽  
Ahmad Reza Bandegi ◽  
Sedighe Yosefi ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Biochemical Parameters ◽  
Cadmium Chloride ◽  
Rat Kidney ◽  
Intraperitoneal Administration ◽  
Kidney Injury ◽  
Protective Role ◽  
Histological Changes ◽  
Male Wistar Rats

Abstract Purpose: Environmental and occupational exposure to cadmium chloride is known to cause nephrotoxicity linked with oxidative stress in humans and animals. This study used Atorvastatin to examine its effect on cadmium chloride-induced nephrotoxicity in rat model using biochemical and histological methodologies.Methods: Experiments were performed on 56 adult male Wistar rats (200 ±20 g), randomly assigned to eight groups. Atorvastatin was administered by oral for 15 days at 20 mg/kg/day, started 7 days before cadmium chloride intraperitoneal administration (1, 2, and 3 mg/kg) for eight days. On day 16, blood samples were collected, and kidneys were excised to evaluate the biochemical and histopathological changes.Cadmium chloride significantly increased malondialdehyde (MDA), serum creatinine (Cr), blood urea nitrogen (BUN), and decreased superoxide dismutase (SOD), glutathione (GSH), and glutathione peroxidase (GPx) levels. Results: Administration of Atorvastatin (20 mg/kg) significantly improved lipid peroxidation, glutathione and activities of antioxidant enzymes and significantly decreased BUN and Creatinine. Atorvastatin clearly improved the histological changes, demonstrating its protective role against Cadmium chloride-induced kidney injury.Conclusion: Treatment with Atorvastatin significantly improves all biochemical parameters and suggests a protecting role against cadmium chloride-induced oxidative stress and histological changes in rat kidney.

scholarly journals Studies on the Genotoxicity Behavior of Silver Nanoparticles in the Presence of Heavy Metal Cadmium Chloride in Mice

2016 ◽  
Vol 2016 ◽  
pp. 1-12 ◽  
Author(s):  
Hanan Ramadan Hamad Mohamed
Keyword(s):  
Heavy Metal ◽  
Dna Damage ◽  
Silver Nanoparticles ◽  
Ag Nanoparticles ◽  
Cadmium Chloride ◽  
Human Life ◽  
Abdominal Cavity ◽  
Sperm Concentration ◽  
Sperm Abnormality ◽  
Polychromatic Erythrocytes

Incredible rapid growth in the nanoparticles applications and development increases the daily human exposure to them but humans are exposed to many other pollutants in addition to nanoparticles that forced us to evaluate the effect of heavy metal cadmium chloride (CdCl2) coinjection on silver nanoparticles induced genotoxic risk in this study. Mice were injected into the abdominal cavity with single dose of Ag nanoparticles (20, 41, and 82 mg/kg) or CdCl2(1.5 mg/kg) either separately or together simultaneously and sacrificed 24 hours later. CdCl2cotreatment enhanced the induced dose-dependent sperm abnormality by Ag nanoparticles different doses as shown by the statistical significant decreases in both sperm concentration and motility and increases in the frequency of abnormal sperms and also potentiated the Ag nanoparticles induced chromosomal and DNA damage indicated by the statistical significant elevations in the frequencies of micronucleated polychromatic erythrocytes (MNPCEs) and DNA damage levels. Moreover, statistical elevations in malondialdehyde level and reductions in catalase activity were observed after CdCl2coinjection with Ag nanoparticles compared with Ag nanoparticles treated groups’ values. Ag nanoparticles induced sperm abnormality, clastogenicity, and genotoxicity were potentiated by heavy metal cadmium coinjection that threatens the human life and increases silver nanoparticles genotoxic risks.

scholarly journals Protection of cadmium chloride induced DNA damage by Lamiaceae plants

2011 ◽  
Vol 1 (5) ◽  
pp. 391-394 ◽  
Author(s):  
Ramaraj Thirugnanasampandan ◽  
Rajarajeswaran Jayakumar
Keyword(s):  
Dna Damage ◽  
Cadmium Chloride

scholarly journals Effect of anthocyanins on selected biochemical parameters in rats exposed to cadmium.

2003 ◽  
Vol 50 (2) ◽  
pp. 543-548 ◽  
Author(s):  
Edward Kowalczyk ◽  
Anna Kopff ◽  
Paweł Fijałkowski ◽  
Maria Kopff ◽  
Jan Niedworok ◽  
...  
Keyword(s):  
Alanine Aminotransferase ◽  
Biochemical Parameters ◽  
Cadmium Chloride ◽  
Activity Concentration ◽  
Human Organism ◽  
Metal Chelating ◽  
Aronia Melanocarpa ◽  
Environmental Toxin ◽  
Chelating Compounds ◽  
Alt Activity

Cadmium is a dangerous occupational and environmental toxin. It accumulates in the human organism mainly in liver and kidneys. Cadmium half-life is about 10 years, so the symptoms of cadmium intoxication may occur several years after the exposure. Until now in treating intoxication with this metal chelating compounds have been used, burdened with numerous undesirable symptoms. In our investigations anthocyanins from Aronia melanocarpa were used to reduce the harmful results caused by cadmium. Administering anthocyanins with cadmium chloride resulted in a statistically significant decrease of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) activity, concentration of bilirubin and urea in blood serum and decreased cadmium cumulation in liver and kidneys in relation to animals receiving cadmium chloride only.

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