Electrophilic, Free Radical and Reactive Oxygen Species Scavenging and Detoxification Potentials of Lophiraalata Stem Bark Extract

2011 ◽  
Vol 1 (3) ◽  
pp. 40-47 ◽  
Author(s):  
Taofeek Olakunle Ajiboye ◽  
Musa Toyin Yakubu ◽  
Adenike Temidayo Oladiji
Keyword(s):  
Reactive Oxygen Species ◽  
Free Radical ◽  
Reactive Oxygen ◽  
Stem Bark ◽  
Bark Extract ◽  
Oxygen Species ◽  
Stem Bark Extract

scholarly journals Salacia campestris root bark extract: peroxidase inhibition, antioxidant and antiradical profile

2009 ◽  
Vol 45 (1) ◽  
pp. 99-107 ◽  
Author(s):  
José Carlos Rebuglio Vellosa ◽  
Najeh Maissar Khalil ◽  
Vânia Ortega Gutierres ◽  
Vânia Aparecida de Freitas Formenton Macedo dos Santos ◽  
Maysa Furlan ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Free Radicals ◽  
Free Radical ◽  
Radical Scavenging ◽  
Reactive Oxygen ◽  
Ethanol Extract ◽  
Active Species ◽  
Bark Extract ◽  
Root Bark ◽  
Oxygen Species

Reactive oxygen species (ROS) and free radical species have been implicated in initiating or accompanying many diseases in living organisms; there is thus, a continual need for antioxidants molecules to inactivate ROS/free radicals. Many studies of plants crude extracts have demonstrated free-radical scavenging and antioxidant action. Salacia species have long been used, in several countries, as traditional medicines against certain diseases and for their anti-inflammatory properties. In this study, Salacia campestris Walp (Hippocrateaceae) root bark ethanol extract (ScEtOH) was assessed for its ability to scavenge free radicals and reactive oxygen species; the results were expressed as percentage inhibition of the active species. ScEtOH was efficient against studied species: DPPH radical (obtained inhibition = 30%), ABTS•+ (IC50 = 1.8±0.8 μg/mL), HOCl (IC50 = 1.7 ± 0.1 μg/mL), O2•- (obtained inhibition = 32%), and NO• (obtained inhibition = 18 %). Peroxidase activity inhibition was evaluated through the guaiacol oxidation reaction catalyzed by hemin, HRP and myeloperoxidase (MPO); data showed that ScEtOH at 10 μg/mL led to 54 and 51% of inhibition, respectively, for the hemin and HRP systems. In the MPO system, ScEtOH promoted a 50% inhibition at 8.9 μg/mL, whereas quercetin, a powerful MPO inhibitor, inhibited this system at 1.35 μg/mL.

scholarly journals The influence of light exposure on free radical processes in the lungs of rats with pleurisy

2016 ◽  
Author(s):  
O. M. Larycheva
Keyword(s):  
Reactive Oxygen Species ◽  
Lipid Peroxidation ◽  
Free Radical ◽  
Light Exposure ◽  
Reactive Oxygen ◽  
Male Rats ◽  
Oxygen Species ◽  
Free Radical Processes ◽  
Radical Processes

The experiments on male rats demonstrated that under the conditions of pleurisy induced by carrageenan and short melatonin deficit, a significant increase in the level of reactive oxygen species and products of lipid peroxidation in the lungs takes place.

Free radical and reactive oxygen species scavenging activities of peanut skins extract

2007 ◽  
Vol 104 (1) ◽  
pp. 242-250 ◽  
Author(s):  
Jing Wang ◽  
Xiaoping Yuan ◽  
Zhengyu Jin ◽  
Yuan Tian ◽  
Huanlu Song
Keyword(s):  
Reactive Oxygen Species ◽  
Free Radical ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Peanut Skins

scholarly journals The Free Radical Theory of Aging and Antioxidant Supplements

2012 ◽  
Vol 17 (3) ◽  
pp. 218-220
Author(s):  
Bruce A. Buehler
Keyword(s):  
Oxidative Stress ◽  
Reactive Oxygen Species ◽  
Free Radicals ◽  
Free Radical ◽  
Life Span ◽  
Reactive Oxygen ◽  
Cell Aging ◽  
Oxygen Species ◽  
Radical Theory ◽  
Antioxidant Supplements

Free radical excess occurs when cells are exposed to reactive oxygen species greater than the amount that can be neutralized by cellular produced antioxidants such as superoxide dismutase. This is termed oxidative stress, which can be caused by excessive energy intake or external pollutants. Excess free radicals are proposed to increase the rate of cell aging, injury, and mutations leading to a shortened cell life span. Vitamins A, C, and E and flavoproteins are supplements that function as free radical scavengers. Antioxidants are present in natural foods but added amounts beyond the diet may detoxify excess free radicals during “oxidative stress.” Antioxidant supplements decrease cellular damage from excess reactive oxygen species but they have not been proven to prolong life span.

Effect of nanosilver surfaces on peptide reactivity towards reactive oxygen species

Nanoscale ◽  
2018 ◽  
Vol 10 (34) ◽  
pp. 15911-15917 ◽  
Author(s):  
Erik Jacques ◽  
Manuel Ahumada ◽  
Brianna Rector ◽  
Goonay Yousefalizadeh ◽  
Constanza Galaz-Araya ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Molecular Dynamics ◽  
Steady State ◽  
Free Radical ◽  
Ultrafast Spectroscopy ◽  
Reactive Oxygen ◽  
Free Radical Oxidation ◽  
Oxygen Species ◽  
Radical Oxidation

Free radical oxidation of CLP-Trp peptides@AgNPs was studied using steady state & ultrafast spectroscopy and molecular dynamics.

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