scholarly journals Use of a xanthine oxidase free radical generating system to investigate the cytotoxic effects of reactive oxygen species on human spermatozoa

Reproduction ◽  
1993 ◽  
Vol 97 (2) ◽  
pp. 441-450 ◽  
Author(s):  
R. J. Aitken ◽  
D. Buckingham ◽  
D. Harkiss
Keyword(s):  
Reactive Oxygen Species ◽  
Free Radical ◽  
Xanthine Oxidase ◽  
Reactive Oxygen ◽  
Human Spermatozoa ◽  
Oxygen Species ◽  
Cytotoxic Effects ◽  
Generating System

scholarly journals Antioxidant effect of phycobiliproteins on proteins and DNA exposed to a reactive oxygen species generating system.

2013 ◽  
Vol 27 (S1) ◽  
Author(s):  
Roxana Olvera‐Ramirez ◽  
Alan Estrada_Perez ◽  
Raul Alcalde_Vazquez ◽  
Jose Luis Muñoz
Keyword(s):  
Reactive Oxygen Species ◽  
Reactive Oxygen ◽  
Antioxidant Effect ◽  
Oxygen Species ◽  
Generating System

scholarly journals Graphene and graphene oxide induce ROS production in human HaCaT skin keratinocytes: the role of xanthine oxidase and NADH dehydrogenase

Nanoscale ◽  
2018 ◽  
Vol 10 (25) ◽  
pp. 11820-11830 ◽  
Author(s):  
Marco Pelin ◽  
Laura Fusco ◽  
Cristina Martín ◽  
Silvio Sosa ◽  
Javier Frontiñán-Rubio ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Graphene Oxide ◽  
Xanthine Oxidase ◽  
Nadh Dehydrogenase ◽  
Reactive Oxygen ◽  
Ros Production ◽  
Oxygen Species ◽  
Mitochondrial Depolarization ◽  
Skin Keratinocytes

Graphene based nanomaterials induce a reactive oxygen species-mediated mitochondrial depolarization, caused by the activation of NADH dehydrogenase and xanthine oxidase.

Cytotoxic effects of metal protoporphyrins in glioblastoma cells: Roles of albumin, reactive oxygen species, and heme oxygenase-1

2008 ◽  
Vol 177 (2) ◽  
pp. 97-107 ◽  
Author(s):  
Jyh-Ming Chow ◽  
Guan-Cheng Huang ◽  
Hui-Yi Lin ◽  
Shing-Chuan Shen ◽  
Liang-Yo Yang ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Heme Oxygenase ◽  
Reactive Oxygen ◽  
Heme Oxygenase 1 ◽  
Oxygen Species ◽  
Glioblastoma Cells ◽  
Cytotoxic Effects

scholarly journals NADPH oxidase-derived reactive oxygen species contribute to impaired cutaneous microvascular function in chronic kidney disease

2014 ◽  
Vol 306 (12) ◽  
pp. F1499-F1506 ◽  
Author(s):  
Jennifer J. DuPont ◽  
Meghan G. Ramick ◽  
William B. Farquhar ◽  
Raymond R. Townsend ◽  
David G. Edwards
Keyword(s):  
Reactive Oxygen Species ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Nadph Oxidase ◽  
Xanthine Oxidase ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Doppler Flowmetry ◽  
Cutaneous Vasodilation ◽  
Oxidase Inhibition

Oxidative stress promotes vascular dysfunction in chronic kidney disease (CKD). We utilized the cutaneous circulation to test the hypothesis that reactive oxygen species derived from NADPH oxidase and xanthine oxidase impair nitric oxide (NO)-dependent cutaneous vasodilation in CKD. Twenty subjects, 10 stage 3 and 4 patients with CKD (61 ± 4 yr; 5 men/5 women; eGFR: 39 ± 4 ml·min−1·1.73 m−2) and 10 healthy controls (55 ± 2 yr; 4 men/6 women; eGFR: >60 ml·min−1·1.73 m−2) were instrumented with 4 intradermal microdialysis fibers for the delivery of 1) Ringer solution (Control), 2) 10 μM tempol (scavenge superoxide), 3) 100 μM apocynin (NAD(P)H oxidase inhibition), and 4) 10 μM allopurinol (xanthine oxidase inhibition). Skin blood flow was measured via laser-Doppler flowmetry during standardized local heating (42°C). Ng-nitro-l-arginine methyl ester (l-NAME; 10 mM) was infused to quantify the NO-dependent portion of the response. Cutaneous vascular conductance (CVC) was calculated as a percentage of the maximum CVC achieved during sodium nitroprusside infusion at 43°C. Cutaneous vasodilation was attenuated in patients with CKD (77 ± 3 vs. 88 ± 3%, P = 0.01), but augmented with tempol and apocynin (tempol: 88 ± 2 ( P = 0.03), apocynin: 91 ± 2% ( P = 0.001). The NO-dependent portion of the response was reduced in patients with CKD (41 ± 4 vs. 58 ± 2%, P = 0.04), but improved with tempol and apocynin (tempol: 58 ± 3 ( P = 0.03), apocynin: 58 ± 4% ( P = 0.03). Inhibition of xanthine oxidase did not alter cutaneous vasodilation in either group ( P > 0.05). These data suggest that NAD(P)H oxidase is a source of reactive oxygen species and contributes to microvascular dysfunction in patients with CKD.

scholarly journals Malaria inflammation by xanthine oxidase‐produced reactive oxygen species

2019 ◽  
Vol 11 (8) ◽  
Author(s):  
Maureen C Ty ◽  
Marisol Zuniga ◽  
Anton Götz ◽  
Sriti Kayal ◽  
Praveen K Sahu ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Xanthine Oxidase ◽  
Reactive Oxygen ◽  
Oxygen Species
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