scholarly journals Extracellular vesicles derived from gut microbiota in inflammatory bowel disease and colorectal cancer: new players?

2021 ◽  
Author(s):  
Giusi Alberti ◽  
Margherita Mazzola ◽  
Carola Gagliardo ◽  
Alessandro Pitruzzella ◽  
Alberto Fucarini ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Inflammatory Bowel Disease ◽  
Gut Microbiota ◽  
Extracellular Vesicles ◽  
Bowel Disease ◽  
Inflammatory Bowel

scholarly journals Study Insights into Gastrointestinal Cancer through the Gut Microbiota

2019 ◽  
Vol 2019 ◽  
pp. 1-8 ◽  
Author(s):  
Fanli Kong ◽  
Yi Cai
Keyword(s):  
Colorectal Cancer ◽  
Inflammatory Bowel Disease ◽  
Gut Microbiota ◽  
Bowel Disease ◽  
Gastrointestinal Diseases ◽  
Human Gut ◽  
Future Studies ◽  
Common Cancer ◽  
Inflammatory Bowel ◽  
Gi Cancers

The gut microbiome in human is recognized as a “microbial organ” for its roles and contributions in regulating the human homeostasis and metabolism. Gastrointestinal (GI) cancers, especially colorectal cancer (CRC), rank as the most common cancer-related deaths worldwide. Evidences have suggested that the disorder of gut microbiota, also named as “dysbiosis,” is related to the development of a variety of diseases such as inflammatory bowel disease (IBD) and the CRC. However, detailed mechanisms between disease and gut microbiota remain largely unknown. This review introduced the correlation between gastrointestinal diseases and the microbiota in human gut from the recent studies, as well as the roles of microbiota in manipulating the CRC and IBDs development, in order to facilitate future studies and to develop novel methods for the precaution, diagnosis, or even cure of gastrointestinal diseases. Additionally, we also elucidated the possibility of probiotics in treatment against CRC.

scholarly journals Intestinal Microbiota Influences DNA Methylome and Susceptibility to Colorectal Cancer

Genes ◽  
2020 ◽  
Vol 11 (7) ◽  
pp. 808
Author(s):  
Aïcha Zouggar ◽  
Joshua R. Haebe ◽  
Yannick D. Benoit
Keyword(s):  
Colorectal Cancer ◽  
Inflammatory Bowel Disease ◽  
Inflammatory Response ◽  
Gut Microbiota ◽  
Intestinal Microbiota ◽  
Bowel Disease ◽  
Colorectal Tumorigenesis ◽  
Epigenetic Programming ◽  
Inflammatory Bowel ◽  
The Impact

In a recent publication, Ansari et al. identified gut microbiota as a critical mediator of the intestinal inflammatory response through epigenetic programming of host intestinal epithelium. Exposure to the microbiota induces Ten-Eleven-Translocation (TET)-dependent hypomethylation of genomic elements regulating genes associated with inflammatory response and colorectal cancer. Here, we discuss the impact of such a discovery on the understanding of how the intestinal microbiota may contribute to epigenetic reprogramming and influence the onset of colorectal tumorigenesis. Finally, we examine the prospect of TET inhibition strategies as a therapeutic and/or preventive approach for colorectal cancer in patients afflicted by inflammatory bowel disease.

Gut microbiota pattern in relation to diet, physical activity and malnutrition in patients with inflammatory bowel disease: cases-control study

2019 ◽  
Author(s):  
Isabel Cornejo-Pareja ◽  
Beatriz Garcia-Munoz ◽  
Eduardo Romero-Perez ◽  
Eduardo Garcia-Fuentes ◽  
S Tapia-Paniagua ◽  
...  
Keyword(s):  
Physical Activity ◽  
Inflammatory Bowel Disease ◽  
Gut Microbiota ◽  
Bowel Disease ◽  
Inflammatory Bowel ◽  
Control Study

scholarly journals Tu1789 – Treatment Response to Ustekinumab and Vedolizumab in Inflammatory Bowel Disease: the Predictive Role of Gut Microbiota

2019 ◽  
Vol 156 (6) ◽  
pp. S-1124
Author(s):  
Clara Caenepeel ◽  
Sara Vieira-Silva ◽  
Jorge F. Vázquez-Castellanos ◽  
Bram Verstockt ◽  
Marc Ferrante ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Gut Microbiota ◽  
Treatment Response ◽  
Bowel Disease ◽  
Predictive Role ◽  
Inflammatory Bowel
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