scholarly journals Correlation between sarcopenia and nailfold microcirculation, serum 25-hydroxycholecalciferol (vitamin D3) and IL-17 levels in female patients with rheumatoid arthritis

2020 ◽  
Author(s):  
Lei Zhang ◽  
Dongmei Mao ◽  
Qi Zhang
Keyword(s):  
Rheumatoid Arthritis ◽  
Vitamin D3 ◽  
Female Patients ◽  
25 Hydroxycholecalciferol

scholarly journals Productive performance of broiler breeder hens fed 25-hydroxycholecalciferol

2009 ◽  
Vol 38 (7) ◽  
pp. 1286-1290 ◽  
Author(s):  
Cibele Araujo Torres ◽  
Sergio Luiz Vieira ◽  
Renata Nuernberg Reis ◽  
André Klein Ferreira ◽  
Pedro Xavier da Silva ◽  
...  
Keyword(s):  
Vitamin D3 ◽  
Egg Production ◽  
Productive Performance ◽  
Broiler Breeder ◽  
Embryo Mortality ◽  
Breeder Hens ◽  
Randomized Design ◽  
Broiler Breeder Hens ◽  
Egg Shells ◽  
25 Hydroxycholecalciferol

An experiment was carried out with the objective of evaluating the addition of 25-hydroxycholecalciferol (25(OH) D3) in diets of broiler breeder hens. The experiment used Cobb 500 broiler breeder hens and was allotted to a complete randomized design with four treatments and eight replications of twenty females and two males each. The treatments consisted of vitamin premixes with 2,000 and 3,400 IU/kg diet vitamin D3 as the only source of vitamin or 2,000 IU D3 plus 35 or 69 mg/t of 25(OH) D3. Results of this experiment indicated that 25(OH) D3 had no significant effect on egg production parameters from 32 to 67 weeks. The supplementation of 25(OH) D3 resulted in better quality egg shells evaluated by the specific gravity at 60 weeks of age, regardless of the dosage. No significant differences were observed for hatchability of broiler breeder fertile eggs at 54 and 64 weeks. At 64 weeks, the hatch residue breakout showed less embryo mortality at the third week for treatments receiving 2,000 UI D3 in the diet and less embryo mortality at the second week of development from hens aged 67 weeks and supplemented with 2,000IU D3 and 2,000IU D3+ 69 mg 25(OH)D3. It was concluded that the supplementation with 25-hydroxycholecalciferol with cholecalciferol had similar effects as the diets with vitamin D3 as the only source on the productive performance of broiler breeder hens.

Effect of Phenobarbitone Treatment on Vitamin D Metabolism in Mammals

1974 ◽  
Vol 46 (4) ◽  
pp. 433-448 ◽  
Author(s):  
J. Silver ◽  
G. Neale ◽  
G. R. Thompson
Keyword(s):  
Vitamin D ◽  
Biological Activity ◽  
Silicic Acid ◽  
Vitamin D3 ◽  
Water Soluble ◽  
Prolonged Treatment ◽  
Vitamin D Metabolism ◽  
Silicic Acid Chromatography ◽  
Polar Metabolites ◽  
25 Hydroxycholecalciferol

1. The metabolism of radioactive cholecalciferol was studied in control and phenobarbitone-treated rats and pigs. 2. Treatment with phenobarbitone enhanced the appearance in plasma of 25-hydroxycholecalciferol (peak IV on silicic acid chromatography), and of more-polar metabolites (peak V), but not of the most-polar metabolites (peak VI). Peak IV had the chromatographic properties of authentic 25-hydroxycholecalciferol (25-HCC) and had biological activity. 3. There was no effect on the appearance of peaks V and VI in plasma after an injection of radioactive 25-HCC. 4. Treatment with phenobarbitone enhanced the excretion of metabolites of radioactive vitamin D3 in bile. These metabolites were largely water-soluble conjugates of peaks IV, V and VI, which included glucuronides. Peak IV in bile was not identical with 25-HCC. 5. Prolonged treatment with phenobarbitone depleted the tissue radioactivity of rats given radioactive vitamin D3.

Menopausal syndrome in female patients with rheumatoid arthritis

2001 ◽  
Vol 11 (3) ◽  
pp. 230-233
Author(s):  
R. Nagamine ◽  
T. Maeda ◽  
T. Shuto ◽  
Y. Nakashima ◽  
G. Hirata ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Menopausal Syndrome ◽  
Female Patients

scholarly journals Polymorphism in the regulatory regions –С2578A and +C936T of the vascular endothelial growth factor (VEGF-A) gene in Russian women with rheumatoid arthritis

2017 ◽  
Vol 89 (5) ◽  
pp. 60-64 ◽  
Author(s):  
A V Shevchenko ◽  
V F Prokofyev ◽  
M A Korolev ◽  
N E Banshchikova ◽  
V I Konenkov
Keyword(s):  
Rheumatoid Arthritis ◽  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Polymorphism Analysis ◽  
Vascular Endothelial ◽  
Vegf Gene ◽  
Regulatory Regions ◽  
Female Patients ◽  
Healthy Women ◽  
Endothelial Growth Factor

Aim. To analyze polymorphism in the regulatory regions of the vascular endothelial growth factor (VEGF) gene in female patients with rheumatoid arthritis (RA). Subjects and methods. The investigation enrolled 257 female patients with RA. A control group consisted of 297 women without chronic diseases. The investigators examined the single-nucleotide polymorphism of VEGF-А2578С in the promoter region (rs699947) and that of VEGF+С936Т 3 in the retranslated region (rs3025039) of the gene. Genotyping was performed by restriction fragment length polymorphism analysis. Results. There was an increase in the frequency of VEGF+936 CT and a reduction in that of the VEGF+936СС genotypes in the seronegative patients as compared to the healthy women. The VEGF+936СС genotype frequency was higher in the patients with seropositive RA than in the subgroup of seronegative patients. The frequency of the VEGF-2578СС genotype was increased in the patients with RA and rheumatoid nodules, as compared to the healthy women. Conclusion. The data presented suggest that the presence of certain VEGF gene variants located in the regulatory regions may reflect the nature of immunopathological mechanisms in RA.

scholarly journals Gut Microbial Composition and Function Are Altered in Patients with Early Rheumatoid Arthritis

2019 ◽  
Vol 8 (5) ◽  
pp. 693 ◽  
Author(s):  
Yunju Jeong ◽  
Ji-Won Kim ◽  
Hyun Ju You ◽  
Sang-Jun Park ◽  
Jennifer Lee ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Gut Microbiome ◽  
Healthy Subjects ◽  
Microbial Composition ◽  
Female Patients ◽  
Early Ra ◽  
Microbial Distribution ◽  
Clusters Of Orthologous Groups ◽  
Associated Functions ◽  
And Function

Rheumatoid arthritis (RA) is an autoimmune disease characterized by synovial inflammation of the joints and extra-articular manifestations. Recent studies have shown that microorganisms affect RA pathogenesis. However, few studies have examined the microbial distribution of early RA patients, particularly female patients. In the present study, we investigated the gut microbiome profile and microbial functions in early RA female patients, including preclinical and clinically apparent RA cases. Changes in microbiological diversity, composition, and function in each group were analyzed using quantitative insights into microbial ecology (QIIME) and phylogenetic investigation of communities by reconstruction of unobserved states (PICRUSt). The results revealed the dysbiosis due to decreased diversity in the early RA patients compared with healthy subjects. There were significant differences in the microbial distribution of various taxa from phylum to genus levels between healthy subjects and early RA patients. Phylum Bacteroidetes was enriched in early RA patients, while Actinobacteria, including the genus Collinsella, was enriched in healthy subjects. Functional analysis based on clusters of orthologous groups revealed that the genes related to the biosynthesis of menaquinone, known to be derived from gram-positive bacteria, were enriched in healthy subjects, while iron transport-related genes were enriched in early RA patients. Genes related to the biosynthesis of lipopolysaccharide, the gram-negative bacterial endotoxin, were enriched in clinically apparent RA patients. The obvious differences in microbial diversity, taxa, and associated functions of the gut microbiota between healthy subjects and early RA patients highlight the involvement of the gut microbiome in the early stages of RA.

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