High levels of macrophage inflammatory protein-1? correlate with prolactin in female patients with active rheumatoid arthritis

1998 ◽  
Vol 17 (3) ◽  
pp. 263-264 ◽  
Author(s):  
W. C. Kullich ◽  
G. Klein
Keyword(s):  
Rheumatoid Arthritis ◽  
Active Rheumatoid Arthritis ◽  
Female Patients ◽  
Inflammatory Protein ◽  
Macrophage Inflammatory Protein

scholarly journals Role of Macrophage Inflammatory Protein-3α and Its Ligand CCR6 in Rheumatoid Arthritis

2003 ◽  
Vol 83 (4) ◽  
pp. 579-588 ◽  
Author(s):  
Jeffrey H Ruth ◽  
Shiva Shahrara ◽  
Christy C Park ◽  
Jacques C M Morel ◽  
Pawan Kumar ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Inflammatory Protein ◽  
Macrophage Inflammatory Protein

scholarly journals Macrophage inflammatory protein 1 alpha expression by synovial fluid neutrophils in rheumatoid arthritis

1999 ◽  
Vol 58 (5) ◽  
pp. 297-302 ◽  
Author(s):  
Y. Hatano ◽  
T. Kasama ◽  
H. Iwabuchi ◽  
R. Hanaoka ◽  
H. T Takeuchi ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Synovial Fluid ◽  
Inflammatory Protein ◽  
Macrophage Inflammatory Protein

scholarly journals Macrophage inflammatory protein-1 alpha. A novel chemotactic cytokine for macrophages in rheumatoid arthritis.

1994 ◽  
Vol 93 (3) ◽  
pp. 921-928 ◽  
Author(s):  
A E Koch ◽  
S L Kunkel ◽  
L A Harlow ◽  
D D Mazarakis ◽  
G K Haines ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Chemotactic Cytokine ◽  
Inflammatory Protein ◽  
Macrophage Inflammatory Protein

Etanercept reduces the serum levels of interleukin-23 and macrophage inflammatory protein-3 alpha in patients with rheumatoid arthritis

2007 ◽  
Vol 28 (2) ◽  
pp. 137-143 ◽  
Author(s):  
Yasunori Kageyama ◽  
Tetsuya Ichikawa ◽  
Tetsuyuki Nagafusa ◽  
Eiji Torikai ◽  
Masahiro Shimazu ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Serum Levels ◽  
Inflammatory Protein ◽  
Interleukin 23 ◽  
Macrophage Inflammatory Protein

scholarly journals Serum Cytokine Profile of Unaffected First-degree Relatives of Patients with Rheumatoid Arthritis

2014 ◽  
Vol 41 (2) ◽  
pp. 280-285 ◽  
Author(s):  
Lillian Barra ◽  
Kelly Summers ◽  
David Bell ◽  
Ewa Cairns
Keyword(s):  
Rheumatoid Arthritis ◽  
Discriminant Analysis ◽  
Disease Onset ◽  
Study Groups ◽  
Cytokine Profile ◽  
Healthy Controls ◽  
First Degree Relatives ◽  
Inflammatory Protein ◽  
Multiplexed Immunoassay ◽  
Macrophage Inflammatory Protein

Objective.Various cytokines have been implicated in the pathogenesis of rheumatoid arthritis (RA) and it is known that elevations in multiple cytokines occur prior to disease onset. The objective of our study is to determine whether the cytokine profile in unaffected first-degree relatives (FDR) of patients with RA is distinct from healthy controls.Methods.The sera of patients with RA, their unaffected FDR, and healthy controls were measured for 27 cytokines using a luminex-based multiplexed immunoassay. Subjects were also tested for rheumatoid factor and 6 different anticitrullinated protein/peptide antibodies (ACPA). Discriminant analysis was performed to define the cytokine profile of the 3 study groups.Results.Fourteen patients with RA, 37 unaffected FDR, and 27 healthy controls were enrolled. All patients with RA and 49% of FDR were ACPA-positive. Patients with RA had elevated levels of inflammatory cytokines compared to FDR and controls. Lower interleukin 13 (IL-13) levels were independently associated with RA. IL-4 was significantly lower in FDR compared to controls. Using discriminant analysis based on the levels of all cytokines measured, RA, FDR, and healthy controls could be distinguished with 91% accuracy. ACPA-positive subjects had higher levels of IL-9, but lower levels of IL-12p70 and macrophage inflammatory protein-1β. No individual cytokine was associated with ACPA-positivity in FDR, but the entire cytokine profile accurately distinguished ACPA-positive from ACPA-negative FDR.Conclusion.The cytokine profiles of patients with RA, healthy controls, unaffected ACPA-positive FDR, and ACPA-negative FDR appear to be distinct.

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