scholarly journals mRNA LEVELS OF PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS AND THEIR COACTIVATORS ARE AFFECTED BY GLUCOSE DEPRIVATION AND OLEATE IN HUMAN HEPATOMA HepG2 CELLS

2007 ◽  
Vol 151 (2) ◽  
pp. 237-245 ◽  
Author(s):  
Katerina Bogdanova ◽  
Lenka Uherkova ◽  
Hana Poczatkova ◽  
Miroslav Rypka ◽  
Jaroslav Vesely
Keyword(s):  
Hepg2 Cells ◽  
Glucose Deprivation ◽  
Peroxisome Proliferator ◽  
Mrna Levels ◽  
Human Hepatoma ◽  
Peroxisome Proliferator Activated Receptors ◽  
Human Hepatoma Hepg2 Cells ◽  
Hepatoma Hepg2

scholarly journals Effects of the rodent peroxisome proliferator and hepatocarcinogen, perfluorooctanoic acid, on apoptosis in human hepatoma HepG2 cells

1999 ◽  
Vol 20 (12) ◽  
pp. 2237-2246 ◽  
Author(s):  
Irina G. Shabalina ◽  
Theoharis Panaretakis ◽  
Anders Bergstrand ◽  
Joseph W. Depierre
Keyword(s):  
Hepg2 Cells ◽  
Perfluorooctanoic Acid ◽  
Peroxisome Proliferator ◽  
Human Hepatoma ◽  
Human Hepatoma Hepg2 Cells ◽  
Hepatoma Hepg2

scholarly journals Flavone Induces Cell Death in Human Hepatoma HepG2 Cells

2014 ◽  
Vol 9 (10) ◽  
pp. 1934578X1400901
Author(s):  
Glaucio Valdameri ◽  
Juliana C. N. Kenski ◽  
Vivian R. Moure ◽  
Marina Trombetta-Lima ◽  
Glaucia R. Martinez ◽  
...  
Keyword(s):  
Cell Death ◽  
Cancer Cells ◽  
Hepg2 Cells ◽  
Annexin V ◽  
Future Application ◽  
Mrna Levels ◽  
Human Hepatoma ◽  
Cytochrome C Release ◽  
Human Hepatoma Hepg2 Cells ◽  
Hepatoma Hepg2

Flavones have received considerable attention because of their antiproliferative properties and selective effects on cancer cells, making them good candidates for use in cancer therapy. In contrast to other flavones, little is known about the effects of the flavone core structure (2-phenyl-4H-1-benzopyran-4one) on cancer cells. Here, we report that flavone induces cell death in human hepatoma HepG2 cells. Furthermore, annexin-V+/PI- and SubG1 populations of HepG2 cells increased after flavone treatment. Exposure of HepG2 to flavone did not result in either cytochrome c release into the cytosol or changes in the mitochondrial membrane potential. Treatment of HepG2 cells with flavone for 24 h reduced the accumulation of intracellular ROS, which correlated with upregulation of Gred, CuZnSOD and MnSOD mRNA levels. Taken together, our results provided useful insights into the mechanism of cell death caused by flavones, in order to evaluate their future application in hepatocarcinoma therapy.

Interaction of PIG11 and Hsp60 is Involved in Apoptosis in Human Hepatoma HepG2 Cells*

2010 ◽  
Vol 37 (10) ◽  
pp. 1138-1143
Author(s):  
Xiao-Min LIU ◽  
Rong HU ◽  
Xiao-Qiu LIANG ◽  
Xiao-Juan WANG ◽  
Yan WU ◽  
...  
Keyword(s):  
Hepg2 Cells ◽  
Human Hepatoma ◽  
Human Hepatoma Hepg2 Cells ◽  
Hepatoma Hepg2
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