scholarly journals CHANGES IN mRNA LEVELS OF INTRACELLULAR FATTY ACID METABOLISM REGULATORS IN HUMAN HEPATOMA HepG2 CELLS FOLLOWING THEIR TREATMENT WITH NON-ESTERIFIED FATTY ACIDS AND DEHYDROEPIANDROSTERONE

2005 ◽  
Vol 149 (2) ◽  
pp. 251-256 ◽  
Author(s):  
Miroslav Rypka ◽  
Katerina Cervenkova ◽  
Lenka Uherkova ◽  
Hana Poczatkova ◽  
Katerina Bogdanova ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Fatty Acid ◽  
Fatty Acid Metabolism ◽  
Hepg2 Cells ◽  
Acid Metabolism ◽  
Mrna Levels ◽  
Human Hepatoma ◽  
Esterified Fatty Acids ◽  
Human Hepatoma Hepg2 Cells ◽  
Hepatoma Hepg2

scholarly journals Effect of Non-Esterified Fatty Acids on Fatty Acid Metabolism-Related Genes in Calf Hepatocytes Culturedin Vitro

2013 ◽  
Vol 32 (5) ◽  
pp. 1509-1516 ◽  
Author(s):  
Peng Li ◽  
Yiming Liu ◽  
Yi Zhang ◽  
Miao Long ◽  
Yang Guo ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Fatty Acid ◽  
Fatty Acid Metabolism ◽  
Acid Metabolism ◽  
Esterified Fatty Acids

scholarly journals Flavone Induces Cell Death in Human Hepatoma HepG2 Cells

2014 ◽  
Vol 9 (10) ◽  
pp. 1934578X1400901
Author(s):  
Glaucio Valdameri ◽  
Juliana C. N. Kenski ◽  
Vivian R. Moure ◽  
Marina Trombetta-Lima ◽  
Glaucia R. Martinez ◽  
...  
Keyword(s):  
Cell Death ◽  
Cancer Cells ◽  
Hepg2 Cells ◽  
Annexin V ◽  
Future Application ◽  
Mrna Levels ◽  
Human Hepatoma ◽  
Cytochrome C Release ◽  
Human Hepatoma Hepg2 Cells ◽  
Hepatoma Hepg2

Flavones have received considerable attention because of their antiproliferative properties and selective effects on cancer cells, making them good candidates for use in cancer therapy. In contrast to other flavones, little is known about the effects of the flavone core structure (2-phenyl-4H-1-benzopyran-4one) on cancer cells. Here, we report that flavone induces cell death in human hepatoma HepG2 cells. Furthermore, annexin-V+/PI- and SubG1 populations of HepG2 cells increased after flavone treatment. Exposure of HepG2 to flavone did not result in either cytochrome c release into the cytosol or changes in the mitochondrial membrane potential. Treatment of HepG2 cells with flavone for 24 h reduced the accumulation of intracellular ROS, which correlated with upregulation of Gred, CuZnSOD and MnSOD mRNA levels. Taken together, our results provided useful insights into the mechanism of cell death caused by flavones, in order to evaluate their future application in hepatocarcinoma therapy.

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