scholarly journals INTERACTION OF AROMATIC CYTOKININS WITH HUMAN LIVER MICROSOMAL CYTOCHROMES P450

2005 ◽  
Vol 149 (2) ◽  
pp. 349-351 ◽  
Author(s):  
Eva Anzenbacherova ◽  
Jakub Janalik ◽  
Igor Popa ◽  
Miroslav Strnad ◽  
Pavel Anzenbacher
Keyword(s):  
Human Liver ◽  
Cytochromes P450 ◽  
Aromatic Cytokinins

Interaction of isoflavonoids with human liver microsomal cytochromes P450: inhibition of CYP enzyme activities

Xenobiotica ◽  
2016 ◽  
Vol 47 (4) ◽  
pp. 324-331 ◽  
Author(s):  
Michaela Kopečná-Zapletalová ◽  
Kristýna Krasulová ◽  
Pavel Anzenbacher ◽  
Petr Hodek ◽  
Eva Anzenbacherová
Keyword(s):  
Enzyme Activities ◽  
Human Liver ◽  
Cytochromes P450

scholarly journals Multiple-Approaches to the Identification and Quantification of Cytochromes P450 in Human Liver Tissue by Mass Spectrometry

2009 ◽  
Vol 8 (4) ◽  
pp. 1672-1681 ◽  
Author(s):  
Cathrin Seibert ◽  
Brian R. Davidson ◽  
Barry J. Fuller ◽  
Laurence H. Patterson ◽  
William J. Griffiths ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Liver Tissue ◽  
Human Liver ◽  
Cytochromes P450 ◽  
Human Liver Tissue ◽  
Identification And Quantification

Characterization of human liver cytochromes P450 by combining the biochemical and proteomic approaches

2006 ◽  
Vol 20 (6) ◽  
pp. 966-974 ◽  
Author(s):  
N.A. Petushkova ◽  
I.P. Kanaeva ◽  
A.V. Lisitsa ◽  
G.F. Sheremetyeva ◽  
V.G. Zgoda ◽  
...  
Keyword(s):  
Human Liver ◽  
Cytochromes P450

scholarly journals Characterization of O-demethylations and Aromatic Hydroxylations Mediated by Cytochromes P450 in the Metabolism of Flavonoid Aglycons

2019 ◽  
Vol 92 (1) ◽  
pp. 115-123 ◽  
Author(s):  
Goran Benković ◽  
Hrvoje Rimac ◽  
Željan Maleš ◽  
Siniša Tomić ◽  
Zoran Lončar ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Human Liver ◽  
Cytochromes P450 ◽  
Liver Microsomes ◽  
Cytochrome P450 Enzymes ◽  
Uv Detector ◽  
Aromatic Hydroxylation ◽  
Metabolism Of Xenobiotics ◽  
Kinetics Of

One of the most important groups of metabolic enzymes is cytochrome P450 superfamily. These enzymes are important in terms of the catalytic diversity and the large number of xenobiotics that are detoxified or activated by converting to reactive metabolites. Flavonoids are xenobiotics to which humans are exposed through diet. Data on their oxidative metabolism mediated by cytochromes P450 are limited. The aim of this study was to determine the enzymatic kinetics of O-demethylation and aromatic hydroxylation of flavonoid aglycons on recombinant cytochrome P450 enzymes and human liver microsomes systems. The study was performed on ten flavonoids, namely 3,7-dihydroxyflavone, 7-hydroxyflavone, acacetin, apigenin, flavone, galangin, kaempferol, naringenin, sakuranetin, and tangeretin using liquid chromatography coupled with mass spectrometry and UV detector. Most relevant enzyme involved in metabolism of flavonoid aglycons is CYP1A2, and its catalytic effectiveness ranges from 0.5 to 2.9 × 106 M–1 min–1. Having in mind high expression and involvement of CYP1A2 in metabolism of xenobiotics including drugs, and its intraindividual differences in expression and activity, potential of drug-flavonoid competitive interactions/inhibitions should be considered when consuming dietary supplement and foods rich in flavonoids.

7-Ethoxycoumarin O-deethylation catalyzed by cytochromes P450 1A2 and 2E1 in human liver microsomes

1996 ◽  
Vol 51 (3) ◽  
pp. 313-319 ◽  
Author(s):  
Hiroshi Yamazaki ◽  
Kiyoshi Inoue ◽  
Mayumi Mimura ◽  
Yoshimitsu Oda ◽  
F.Peter Guengerich ◽  
...  
Keyword(s):  
Human Liver ◽  
Cytochromes P450 ◽  
Liver Microsomes ◽  
Human Liver Microsomes

CHARACTERIZATION OF TESTOSTERONE 11β-HYDROXYLATION CATALYZED BY HUMAN LIVER MICROSOMAL CYTOCHROMES P450

2005 ◽  
Vol 33 (6) ◽  
pp. 714-718 ◽  
Author(s):  
Man Ho Choi ◽  
Paul L. Skipper ◽  
John S. Wishnok ◽  
Steven R. Tannenbaum
Keyword(s):  
Human Liver ◽  
Cytochromes P450
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