scholarly journals Images – Penile pain in the setting of end-stage renal disease: An unusual anatomic location for calciphylaxis

2021 ◽  
Vol 16 (5) ◽  
Author(s):  
Ummah Salma Nisar ◽  
John C. Cheville ◽  
Charles D. Sturgis
Keyword(s):  
End Stage Renal Disease ◽  
Calcium Metabolism ◽  
Disease Diagnosis ◽  
End Stage Kidney Disease ◽  
Vascular Calcifications ◽  
Surgical Interventions ◽  
Chronic Renal Impairment ◽  
Penile Pain ◽  
Stage Renal Disease ◽  
End Stage

In this report, we present a case of penile calciphylaxis, an extremely rare and serious condition occurring in association with dysregulation of systemic calcium metabolism in the setting of chronic renal impairment. Calciphylaxis can occur at various body sites and is associated with diffuse vascular calcifications in small and medium-sized arteries of the involved tissues. Penile calciphylaxis has a grim prognosis. Calciphylaxis is an important etiologic differential diagnosis for penile necrosis and penile pain in patient’s being treated with dialysis for end-stage kidney disease. Diagnosis of penile calciphylaxis is possible via clinical and radiological evaluations. Medical management may alleviate symptoms; however surgical interventions may be necessary, and histological studies may allow for definitive classification.

scholarly journals Arterial stiffening and vascular calcifications in end‐stage renal disease

2000 ◽  
Vol 15 (7) ◽  
pp. 1014-1021 ◽  
Author(s):  
Alain P. Guérin ◽  
Gérard M. London ◽  
Sylvain J. Marchais ◽  
Fabien Metivier
Keyword(s):  
Renal Disease ◽  
End Stage Renal Disease ◽  
Vascular Calcifications ◽  
Arterial Stiffening ◽  
Stage Renal Disease ◽  
End Stage

scholarly journals Prevalence, risk factors and disease knowledge of polycystic kidney disease in Pakistan

2020 ◽  
Vol 34 ◽  
pp. 205873842096608
Author(s):  
Rabia Zahid ◽  
Muhammad Akram ◽  
Ejaz Rafique
Keyword(s):  
Family History ◽  
Kidney Disease ◽  
Renal Disease ◽  
Polycystic Kidney Disease ◽  
End Stage Renal Disease ◽  
Positive Family History ◽  
Polycystic Kidney ◽  
Surgical Interventions ◽  
Stage Renal Disease ◽  
End Stage

Polycystic kidneys disease refers to cyst(s) formation in kidneys with severe consequences of end stage renal disease thus have higher mortality. It is a common genetic disease occurring either as autosomal dominant polycystic kidney (ADPKD) or autosomal recessive polycystic kidney disease (ARPKD) with prevalence rates of 1/1000 and 1/40,000 respectively. Dominant forms presenting in later (>30) while recessive in earlier ages (infancy) and affecting both sexes and almost all race. The patient experiences many renal as well as extra-renal manifestations with marked hypertension and cyst formation in other organs predominantly in liver. Due to genetic basis, positive family history is considered as major risk factor. Ultrasonography remains the main stay of diagnosis along with family history, by indicating increased renal size and architectural modifications. Initially disease remains asymptomatic, later on symptomatic treatment is suggested with surgical interventions like cyst decortications or drainage. Dialysis proved to be beneficial in end stage renal disease. However renal transplantation is the treatment of choice.

scholarly journals Coagulopathy and Extremely Elevated PT/INR after Dabigatran Etexilate Use in a Patient with End-Stage Renal Disease

2013 ◽  
Vol 2013 ◽  
pp. 1-4 ◽  
Author(s):  
Joonseok Kim ◽  
Mrinal Yadava ◽  
In Chul An ◽  
Abrar Sayeed ◽  
Heather S. Laird-Fick ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Renal Disease ◽  
End Stage Renal Disease ◽  
Dabigatran Etexilate ◽  
International Normalized Ratio ◽  
Thrombin Inhibitor ◽  
Close Monitoring ◽  
Chronic Renal Impairment ◽  
Stage Renal Disease ◽  
End Stage

Introduction.Dabigatran is an oral direct thrombin inhibitor which has been approved for prophylaxis of stroke in patients with atrial fibrillation. The use of dabigatran etexilate increased rapidly due to many benefits. However, questions have been raised constantly regarding the safety of dabigatran etexilate.Case.A 58-year-old Caucasian male with a history of recurrent paroxysmal atrial fibrillation status after pacemaker and end-stage renal disease on hemodialysis came to the Emergency Department with the complaint of severe epistaxis. He had been started on dabigatran 150 mg twice a day about 4 months ago as an outpatient by his cardiologist. His prothrombin time (PT) was 63 seconds with international normalized ratio (INR) of 8.8 and his activated partial thromboplastin time (aPTT) was 105.7 seconds. Otherwise, all labs were unremarkable including the liver function test. Dabigatran was stopped immediately. His INR and aPTT trended downward, reaching normal levels 5 days after admission.Conclusion.Dabigatran is contraindicated in patients with severe kidney insufficiency as it is predominantly excreted via the kidney (~80%). Elderly patients over 75 and patients with chronic renal impairment should be carefully evaluated before starting dabigatran. Despite studies showing only mild increase in aPTT and PT/INR in patients receiving dabigatran, close monitoring may be reasonable in patients with renal insufficiency.

scholarly journals End-stage renal disease, calcification patterns and clinical outcomes after TAVI

2021 ◽  
Author(s):  
David Grundmann ◽  
Matthias Linder ◽  
Alina Goßling ◽  
Lisa Voigtländer ◽  
Sebastian Ludwig ◽  
...  
Keyword(s):  
Renal Disease ◽  
End Stage Renal Disease ◽  
Multivariable Analysis ◽  
Clinical Results ◽  
Chronic Hemodialysis ◽  
Vascular Calcifications ◽  
Major Life ◽  
Term Survival ◽  
Stage Renal Disease ◽  
End Stage

Abstract Background Patients with chronic hemodialysis due to end-stage renal disease (ESRD) or severely impaired kidney function (CKD) constitute a relevant share of patients undergoing trans-catheter aortic valve implantation (TAVI). However, data on specific challenges and outcomes remain limited. Aim We aimed to characterize this patient population, evaluate clinical results and assess the significance of calcification patterns. Methods This retrospective single-center analysis evaluated 2,712 TAVI procedures (2012–2019) according to baseline renal function: GFR < 30 ml/min/1.73m2 (CKD; n = 210), chronic hemodialysis (ESRD; n = 119) and control (CTRL; n = 2383). Valvular and vascular calcification patterns were assessed from contrast-enhanced multi-detector computed tomography. Outcomes were evaluated in accordance with the VARC-2 definitions. Results Operative risk was higher in ESRD and CKD vs. CTRL (STS-score 8.4% and 7.6% vs. 3.9%, p < 0.001) and patients with ESRD had more severe vascular calcifications (49.1% vs. 33.9% and 29.0%, p < 0.01). Immediate procedural results were similar but non-procedure-related major/life-threatening bleeding was higher in ESRD and CKD (5.0% and 5.3% vs. 1.6%, p < 0.01). 3-year survival was impaired in patients with ESRD and CKD (33.3% and 35.3% vs. 65.4%, p < 0.001). Multivariable analysis identified ESRD (HR 1.60), CKD (HR 1.79) and vascular calcifications (HR 1.29) as predictors for 3-year and vascular calcifications (HR 1.51) for 30-day mortality. Conclusion Patients with ESRD and CKD constitute a vulnerable patient group with extensive vascular calcifications. Immediate procedural results were largely unaffected by renal impairment, yielding TAVI a particularly valuable treatment option in these high-risk operative patients. Mid-term survival was determined by underlying renal disease, cardiovascular comorbidities, and vascular calcifications as a novel risk marker. Graphical abstract

scholarly journals Laurence-Moon-Bardet-Biedl Syndrome: A 19 Years Girl with Total Blindness and End Stage Renal Disease

2014 ◽  
Vol 15 (1) ◽  
pp. 94-97
Author(s):  
Matiur Rahman ◽  
Nurul Islam ◽  
Sarmistha Biswas ◽  
H A Zaved ◽  
Gourab Dewan
Keyword(s):  
End Stage Renal Disease ◽  
Autosomal Recessive ◽  
Renal Involvement ◽  
Autosomal Recessive Disorder ◽  
End Stage Kidney Disease ◽  
Bardet Biedl Syndrome ◽  
Prognostic Importance ◽  
Total Blindness ◽  
Stage Renal Disease ◽  
End Stage

Laurence-Moon-Bardet-Biedl syndrome is a rare autosomal recessive disorder characterized bystructural and functional abnormalities of different organ and tissues. Renal involvement is the single most feature of prognostic importance. We report a case with end stage kidney disease. The diagnosis was missed until patient presented with renal dysfunction. Early diagnosis and screening for renal involvement is crucial for prolong survival.DOI: http://dx.doi.org/10.3329/jom.v15i1.19885 J Medicine 2014; 15: 94-97

scholarly journals Assessment of Arterial Stiffening and Vascular Calcifications in End‐Stage Renal Disease Patients

2017 ◽  
Vol 07 (04) ◽  
pp. 131-143
Author(s):  
Mahmoud Kamal Elsamman ◽  
Mohamed Abdel Wahab Ezzat ◽  
Medhat Ibraheem Mohammad ◽  
Raghda Gamal Mostafa ◽  
Ali Taha Ali Hassan
Keyword(s):  
Renal Disease ◽  
End Stage Renal Disease ◽  
Vascular Calcifications ◽  
Arterial Stiffening ◽  
Stage Renal Disease ◽  
End Stage

scholarly journals Has Covid-19 reduced the management of end-stage kidney disease in 2020?

2021 ◽  
Vol 4 (1) ◽  
pp. 53-54
Author(s):  
Jacobs Lucas Pierre-michel ◽  
Frederic Collart ◽  
Thomas Baudoux ◽  
Catherine Bonvoisin ◽  
Jean-Marc De Smet ◽  
...  
Keyword(s):  
Kidney Disease ◽  
Renal Disease ◽  
End Stage Renal Disease ◽  
Dialysis Initiation ◽  
Ambulatory Patient ◽  
End Stage Kidney Disease ◽  
Marked Decline ◽  
Stage Renal Disease ◽  
End Stage

The SARS-CoV-2 pandemic has been associated with a drop in diagnoses of several diseases in 2020, including cancers. In this letter addressed to the editor, the Groupement des Néphrologues Francophones de Belgique (GNFB), assessed whether there was a similar effect concerning end-stage renal disease (ESRD). Data of patients with ESRD form 25 of the 26 centers constituting the GNFB register were collected. In conclusion, the year 2020 was marked by an 8% drop in the incidence of overall treatments for ESRD. A particularly marked decline in outpatient dialysis initiation programs (PD and HDD). In addition, the interruption of transplant programs in academic centers as well as the closure of ambulatory patient clinics in a majority of hospitals was associated with a delay in nephrological management.

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