scholarly journals Assessment of Arterial Stiffening and Vascular Calcifications in End‐Stage Renal Disease Patients

2017 ◽  
Vol 07 (04) ◽  
pp. 131-143
Author(s):  
Mahmoud Kamal Elsamman ◽  
Mohamed Abdel Wahab Ezzat ◽  
Medhat Ibraheem Mohammad ◽  
Raghda Gamal Mostafa ◽  
Ali Taha Ali Hassan
Keyword(s):  
Renal Disease ◽  
End Stage Renal Disease ◽  
Vascular Calcifications ◽  
Arterial Stiffening ◽  
Stage Renal Disease ◽  
End Stage

scholarly journals Arterial stiffening and vascular calcifications in end‐stage renal disease

2000 ◽  
Vol 15 (7) ◽  
pp. 1014-1021 ◽  
Author(s):  
Alain P. Guérin ◽  
Gérard M. London ◽  
Sylvain J. Marchais ◽  
Fabien Metivier
Keyword(s):  
Renal Disease ◽  
End Stage Renal Disease ◽  
Vascular Calcifications ◽  
Arterial Stiffening ◽  
Stage Renal Disease ◽  
End Stage

scholarly journals End-stage renal disease, calcification patterns and clinical outcomes after TAVI

2021 ◽  
Author(s):  
David Grundmann ◽  
Matthias Linder ◽  
Alina Goßling ◽  
Lisa Voigtländer ◽  
Sebastian Ludwig ◽  
...  
Keyword(s):  
Renal Disease ◽  
End Stage Renal Disease ◽  
Multivariable Analysis ◽  
Clinical Results ◽  
Chronic Hemodialysis ◽  
Vascular Calcifications ◽  
Major Life ◽  
Term Survival ◽  
Stage Renal Disease ◽  
End Stage

Abstract Background Patients with chronic hemodialysis due to end-stage renal disease (ESRD) or severely impaired kidney function (CKD) constitute a relevant share of patients undergoing trans-catheter aortic valve implantation (TAVI). However, data on specific challenges and outcomes remain limited. Aim We aimed to characterize this patient population, evaluate clinical results and assess the significance of calcification patterns. Methods This retrospective single-center analysis evaluated 2,712 TAVI procedures (2012–2019) according to baseline renal function: GFR < 30 ml/min/1.73m2 (CKD; n = 210), chronic hemodialysis (ESRD; n = 119) and control (CTRL; n = 2383). Valvular and vascular calcification patterns were assessed from contrast-enhanced multi-detector computed tomography. Outcomes were evaluated in accordance with the VARC-2 definitions. Results Operative risk was higher in ESRD and CKD vs. CTRL (STS-score 8.4% and 7.6% vs. 3.9%, p < 0.001) and patients with ESRD had more severe vascular calcifications (49.1% vs. 33.9% and 29.0%, p < 0.01). Immediate procedural results were similar but non-procedure-related major/life-threatening bleeding was higher in ESRD and CKD (5.0% and 5.3% vs. 1.6%, p < 0.01). 3-year survival was impaired in patients with ESRD and CKD (33.3% and 35.3% vs. 65.4%, p < 0.001). Multivariable analysis identified ESRD (HR 1.60), CKD (HR 1.79) and vascular calcifications (HR 1.29) as predictors for 3-year and vascular calcifications (HR 1.51) for 30-day mortality. Conclusion Patients with ESRD and CKD constitute a vulnerable patient group with extensive vascular calcifications. Immediate procedural results were largely unaffected by renal impairment, yielding TAVI a particularly valuable treatment option in these high-risk operative patients. Mid-term survival was determined by underlying renal disease, cardiovascular comorbidities, and vascular calcifications as a novel risk marker. Graphical abstract

scholarly journals Arterial Stiffness in Chronic Kidney Disease and End-Stage Renal Disease

2018 ◽  
Vol 45 (1-3) ◽  
pp. 154-158 ◽  
Author(s):  
Gerard M. London
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Arterial Stiffness ◽  
Renal Disease ◽  
End Stage Renal Disease ◽  
Left Ventricular ◽  
Coronary Perfusion ◽  
Arterial Stiffening ◽  
Stage Renal Disease ◽  
End Stage

Accelerated ageing is observed in patients with chronic kidney disease (CKD)/end-stage renal disease. Premature vascular aging and arterial stiffening are the most characteristic features of this “progeria” that is already observed in those with the early stages of CKD. Aortic stiffening is associated with high characteristic impedance, left ventricular hypertrophy, decreased coronary perfusion, and is a strong prognostic marker of mortality and cardiovascular morbidity. With aging, the arterial stiffening is more pronounced in the aorta and central arteries than in peripheral conduit arteries. This leads to progressive decrease and inversion of the arterial stiffness gradient and systemic reflection coefficient, leading to less protection of the microcirculation in the event of high-pressure transmission towards it Arterial stiffening is multifactorial with systemic microinflammation being one of the most important associated factors primarily associated with vascular calcifications.

scholarly journals Tumour Calcification and Calciphylaxis in End-Stage Renal Disease

2014 ◽  
Vol 2014 ◽  
pp. 1-2
Author(s):  
Jia Di ◽  
Zhenxing Jiang ◽  
Min Yang
Keyword(s):  
Septic Shock ◽  
Renal Disease ◽  
End Stage Renal Disease ◽  
Rare Case ◽  
Systemic Infection ◽  
Vascular Calcifications ◽  
All Cause Mortality ◽  
The Right ◽  
Stage Renal Disease ◽  
End Stage

Although soft tissue and vascular calcifications are common in CKD and progress as an independent risk factor of all-cause mortality, tumour calcification and calciphylaxis are uncommon in patients with end-stage renal disease (ESRD). Here, we discuss a rare case of a patient with tumour calcification complicated with calciphylaxis developed septic shock from infection. Our patient is a 57-year-old man in his late stage of renal disease who presented with a huge mass at the right hip and necrotic cutaneous ulcers on the lower legs followed by local and systemic infection and death due to septic shock.

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