scholarly journals Maternal serum placental growth factor and pregnancy-associated plasma protein A measured in the first trimester as parameters of subsequent pre-eclampsia and small-for-gestational-age infants: A prospective observational study

2017 ◽  
Vol 60 (2) ◽  
pp. 154 ◽  
Author(s):  
Kyung Uk Sung ◽  
Jeong A Roh ◽  
Kyung Jin Eoh ◽  
Eui Hyeok Kim
Keyword(s):  
Growth Factor ◽  
Observational Study ◽  
Plasma Protein ◽  
Gestational Age ◽  
Small For Gestational Age ◽  
Prospective Observational Study ◽  
Protein A ◽  
First Trimester ◽  
Maternal Serum ◽  
Placental Growth Factor

scholarly journals The Relationship Between First-Trimester Aneuploidy Markers and Birth Weight

2021 ◽  
pp. 1-6
Author(s):  
Cenk Soysal ◽  
İsmail Biyik ◽  
Özlem Erten ◽  
Onur Ince ◽  
Hatice Sari ◽  
...  
Keyword(s):  
Plasma Protein ◽  
Gestational Age ◽  
Small For Gestational Age ◽  
Protein A ◽  
First Trimester ◽  
Nuchal Translucency ◽  
Maternal Serum ◽  
Large For Gestational Age ◽  
Aneuploidy Screening ◽  
Beta Human Chorionic Gonadotropin

OBJECTIVE: We aimed to determine the relationship between the first-trimester aneuploidy screeningma and the predicted weight at birth: Small for gestational age and large for gestational age. STUDY DESIGN: 594 low-risk pregnant women with a singleton pregnancy, who underwent first-trimester aneuploidy screening by measuring nuchal translucency, maternal serum free beta-human chorionic gonadotropin, and pregnancy-associated plasma protein-A were included in the study. Those weighing above the 3rd percentile and below the 10th percentile were defined as small for gestational age, and those over the 90th percentile were defined as large for gestational age. RESULTS: A total of 594 pregnant women were enrolled. The mean maternal age of the studied group was 28.8±5.5 years. Low maternal serum pregnancy-associated plasma protein-A levels and decreased nuchal translucency measurements were associated with the small for gestational age newborn (p<0.001 and p=0.001, respectively). There is a significant correlation with large for gestational age for newborns only with an increase in maternal serum pregnancy-associated plasma protein-A levels (p=0.001). beta-human chorionic gonadotropin levels were not associated with the birth weight (p=0.735). CONCLUSION: Maternal serum pregnancy-associated plasma protein-A levels, one of the markers in first-trimester aneuploidy screening, can be used in the prediction of small for gestational age and large for gestational age However, due to its low correlation, it is not a suitable screening test for clinical practice.

scholarly journals Soluble fms-Like Tyrosine Kinase 1 Is Increased in Preeclampsia But Not in Normotensive Pregnancies with Small-for-Gestational-Age Neonates: Relationship to Circulating Placental Growth Factor

2005 ◽  
Vol 90 (8) ◽  
pp. 4895-4903 ◽  
Author(s):  
Eiji Shibata ◽  
Augustine Rajakumar ◽  
Robert W. Powers ◽  
Robert W. Larkin ◽  
Carol Gilmour ◽  
...  
Keyword(s):  
Growth Factor ◽  
Tyrosine Kinase ◽  
Gestational Age ◽  
Small For Gestational Age ◽  
Vascular Dysfunction ◽  
Normal Pregnancy ◽  
Maternal Serum ◽  
Placental Growth Factor ◽  
Gestational Age At Delivery ◽  
Placental Protein

Context: An excess of the soluble receptor, fms-like tyrosine kinase 1 (sFlt-1) may contribute to maternal vascular dysfunction in women with preeclampsia by binding and thereby reducing concentrations of free vascular endothelial growth factor and placental growth factor (PlGF) in the circulation. The putative stimulus for increased sFlt-1 during preeclampsia, placental hypoxia due to poor perfusion, is common to both preeclampsia and idiopathic intrauterine growth restriction. However, the latter condition occurs without maternal vascular disease. Objective: We asked whether, as with preeclampsia, sFlt-1 is increased and free PlGF is decreased in villous placenta and maternal serum of normotensive women with small-for-gestational-age (SGA) neonates. Study Design: This was a case-control study using banked samples. Groups of women with SGA neonates (birth weight centile &lt; 10th) and women with preeclampsia were matched to separate sets of normal pregnancy controls based on gestational age at blood sampling (serum) or gestational age at delivery (placenta). Results: sFlt-1 levels were higher in preeclamptics than controls (serum, P &lt; 0.0001; placental protein, P = 0.03; placental mRNA, P = 0.007) but not increased in SGA pregnancies. PlGF was lower in both preeclampsia (serum, P &lt; 0.0001; placental protein, P = 0.05) and SGA (serum, P = 0.0008; placental protein, P = 0.03) compared with their controls. PlGF in preeclampsia and SGA groups did not differ. Conclusions: These data are consistent with a role for sFlt-1 in the maternal manifestations of preeclampsia. In contrast to preeclampsia, sFlt-1 does not appear to contribute substantially to decreased circulating free PlGF in SGA pregnancies in the absence of a maternal syndrome.

Maternal serum placental growth factor (PlGF) in small for gestational age pregnancy at 11+0to 13+6weeks of gestation

2008 ◽  
Vol 28 (12) ◽  
pp. 1110-1115 ◽  
Author(s):  
Leona C. Y. Poon ◽  
Edgar Zaragoza ◽  
Ranjit Akolekar ◽  
Evangelos Anagnostopoulos ◽  
Kypros H. Nicolaides
Keyword(s):  
Growth Factor ◽  
Gestational Age ◽  
Small For Gestational Age ◽  
Maternal Serum ◽  
Placental Growth Factor

scholarly journals First-trimester prediction of preeclampsia: A comparison between Pregnancy-associated plasma protein-A and Placental growth factor

2022 ◽  
Vol 226 (1) ◽  
pp. S454-S455
Author(s):  
Alexandre Fillion ◽  
Paul Guerby ◽  
Cédric Gasse ◽  
Francois Audibert ◽  
Amélie Boutin ◽  
...  
Keyword(s):  
Growth Factor ◽  
Plasma Protein ◽  
Protein A ◽  
First Trimester ◽  
Placental Growth Factor

Efficiency of first-trimester growth restriction and low pregnancy-associated plasma protein-A in predicting small for gestational age at delivery

2012 ◽  
Vol 32 (8) ◽  
pp. 724-729 ◽  
Author(s):  
Jeanine F. Carbone ◽  
Methodius G. Tuuli ◽  
Rachael Bradshaw ◽  
Julie Liebsch ◽  
Anthony O. Odibo
Keyword(s):  
Plasma Protein ◽  
Gestational Age ◽  
Small For Gestational Age ◽  
Protein A ◽  
First Trimester ◽  
Growth Restriction ◽  
Gestational Age At Delivery
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