Efficiency of first-trimester growth restriction and low pregnancy-associated plasma protein-A in predicting small for gestational age at delivery

2012 ◽  
Vol 32 (8) ◽  
pp. 724-729 ◽  
Author(s):  
Jeanine F. Carbone ◽  
Methodius G. Tuuli ◽  
Rachael Bradshaw ◽  
Julie Liebsch ◽  
Anthony O. Odibo
Keyword(s):  
Plasma Protein ◽  
Gestational Age ◽  
Small For Gestational Age ◽  
Protein A ◽  
First Trimester ◽  
Growth Restriction ◽  
Gestational Age At Delivery

scholarly journals The Relationship Between First-Trimester Aneuploidy Markers and Birth Weight

2021 ◽  
pp. 1-6
Author(s):  
Cenk Soysal ◽  
İsmail Biyik ◽  
Özlem Erten ◽  
Onur Ince ◽  
Hatice Sari ◽  
...  
Keyword(s):  
Plasma Protein ◽  
Gestational Age ◽  
Small For Gestational Age ◽  
Protein A ◽  
First Trimester ◽  
Nuchal Translucency ◽  
Maternal Serum ◽  
Large For Gestational Age ◽  
Aneuploidy Screening ◽  
Beta Human Chorionic Gonadotropin

OBJECTIVE: We aimed to determine the relationship between the first-trimester aneuploidy screeningma and the predicted weight at birth: Small for gestational age and large for gestational age. STUDY DESIGN: 594 low-risk pregnant women with a singleton pregnancy, who underwent first-trimester aneuploidy screening by measuring nuchal translucency, maternal serum free beta-human chorionic gonadotropin, and pregnancy-associated plasma protein-A were included in the study. Those weighing above the 3rd percentile and below the 10th percentile were defined as small for gestational age, and those over the 90th percentile were defined as large for gestational age. RESULTS: A total of 594 pregnant women were enrolled. The mean maternal age of the studied group was 28.8±5.5 years. Low maternal serum pregnancy-associated plasma protein-A levels and decreased nuchal translucency measurements were associated with the small for gestational age newborn (p<0.001 and p=0.001, respectively). There is a significant correlation with large for gestational age for newborns only with an increase in maternal serum pregnancy-associated plasma protein-A levels (p=0.001). beta-human chorionic gonadotropin levels were not associated with the birth weight (p=0.735). CONCLUSION: Maternal serum pregnancy-associated plasma protein-A levels, one of the markers in first-trimester aneuploidy screening, can be used in the prediction of small for gestational age and large for gestational age However, due to its low correlation, it is not a suitable screening test for clinical practice.

scholarly journals Obstetric Outcome in Pregnant Patients with Low Level of Pregnancy-Associated Plasma Protein A in First Trimester

2018 ◽  
Vol 6 (6) ◽  
pp. 1028-1031 ◽  
Author(s):  
Vesna Livrinova ◽  
Igor Petrov ◽  
Igor Samardziski ◽  
Viktorija Jovanovska ◽  
Slagjana Simeonova-Krstevska ◽  
...  
Keyword(s):  
Plasma Protein ◽  
Placental Abruption ◽  
Protein A ◽  
First Trimester ◽  
Target Group ◽  
Growth Restriction ◽  
Control Group ◽  
Unfavourable Outcome ◽  
Fetal Demise ◽  
A Value

BACKGROUND: Pregnancy-associated plasma protein A (PAPP-A), is a protease which releases Insulin-like growth factor. The role of this factor is stimulation of cell mitosis, differentiation and trophoblastic invasion of deciduas. Identification of patients with low PAPP-A (under 0.4 MoM in the first trimester has an influence on birth weight, attenuation of fetal growth, preeclampsia, birth and fetal demise.AIM: The main issue in the study is evaluating an influence of PAPP-A, calculated in the first trimester on the unfavourable outcome of pregnancy.MATERIAL AND METHODS: Seventy pregnant women with singleton pregnancy underwent first-trimester biochemical screening. The target group were women with PAPP-A below 0.4 MoM, and in control group, PAPP-A were оver 0.4 MoM. There was an assessment of the influence on the mode of delivery, gestational week, the presence of intrauterine growth restriction, preeclampsia, temporary birth, intrauterine fetal demise and newborn condition.RESULTS: In target group, consisted of 35 patients, 16 were delivered at term. From 28 to 37 g.w.- were 7 patient, 22-28 g.w.- 4 and 8 patients were under the 22 g.w (all with fetal demise) there were 19 pretemporary deliveries - 9 with Cesarean Section (SC). In the target group: 5 newborn wеre with IUGR, 6 women had preeclampsia, 1 had placental abruption. In control group were 35 patients: 28 delivered at term, 9 with SC, 26 vaginal deliveries; with IUGR were 4 newborns. Two newborns were hypertrophic.CONCLUSION: There is a significant difference in unfavourable outcome in the cases with PAPP-A under 0.4 Mom, particular in the group, with a PAPP-A value under 0.2 MoM. The patients delivered with SC with the main indications in utero hypoxia, growth restriction and elevated blood pressure had PAPP-A between 0.3-0.4 MoM. The patients with intrauterine fetal death and placental abruption in the most of the cases have PAPP-A value under 0.2 MoM. There is a need to be aware in these pregnancies to achieve the preventions of adverse outcome, to decrease perinatal morbidity and mortality.

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