THE CORRELATION BETWEEN PARAMETERS OF UMBILICAL CORD BLOOD COUNT AND BRAIN DAMAGE IN NEWBORNS WITH PERINATAL ASPHYXIA

2014 ◽  
Vol 42 (1) ◽  
Author(s):  
Amela Selimović ◽  
Fahrija Skokić ◽  
Selma Muratović ◽  
Selmira Brkić ◽  
Nermina Dedić ◽  
...  
Keyword(s):  
Cord Blood ◽  
Brain Damage ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Blood Count ◽  
Perinatal Asphyxia

Feasibility of umbilical cord blood (UCB) collection in neonates at high risk of brain damage

2018 ◽  
Author(s):  
A Segler ◽  
A Schwickert ◽  
CR Weiß ◽  
C Bührer ◽  
T Braun ◽  
...  
Keyword(s):  
High Risk ◽  
Cord Blood ◽  
Brain Damage ◽  
Umbilical Cord ◽  
Umbilical Cord Blood

scholarly journals Optimization of Hypoxic Brain Injuries Diagnostics in Full-Term Newborns

2021 ◽  
Vol 6 (2) ◽  
pp. 133-141
Author(s):  
M. S. Panova ◽  
A. S. Panchenko ◽  
V. A. Mudrov
Keyword(s):  
Cord Blood ◽  
Brain Damage ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Full Term ◽  
Damage Diagnosis ◽  
Hypoxic Brain Damage ◽  
Hypoxic Brain ◽  
Tnf Α ◽  
Term Newborns

The problem of early diagnosis of the central nervous system damage in newborn before the onset of clinical symptoms remains relevant at the present time.The aim of the study was to optimize the hypoxic brain damage diagnosis in full-term newborns by analyzing the concentration of cytokines in the umbilical cord blood.Materials and methods. During the first stage of the study, a prospective analysis of concentrations of interleukins (IL-1β, IL-4, IL-6, IL-8, IL-10), TNF-α and neuron-specific enolase (NSE) in the umbilical cord blood serum of full-term newborns was performed. The second stage of the study included the retrospective analysis of clinical data and instrumental research methods. The main method for diagnosing in the development of hypoxic brain damage in newborns was neurosonography.Results. The development of hypoxic brain damage is evidenced by the concentration of IL-1β over 30.3 pg/ml, IL-4 – over 1.7 pg/ml, IL-6 – over 79.4 pg/ml, IL-8 – over 107.7 pg/ml, NSE – more than 10.3 ng/ml and TNF-α – more than 1.6 pg/ml in umbilical cord blood.Conclusion. The results of the study confirmed that the comprehensive assessment of the cytokines concentration in the umbilical cord blood improves the hypoxic brain damage diagnosis in newborns. Analysis of the level of these markers immediately after the birth will optimize the management tactics of newborns who have undergone hypoxic exposure in antenatal and intranatal period. 

scholarly journals Laboratory Characteristics of Umbilical Cord Blood in Makurdi North-Central Nigeria

2018 ◽  
Vol 1 (4) ◽  
pp. 228-233
Author(s):  
A I Nwannadi ◽  
T Z Swende ◽  
O O Alao ◽  
H I Aba ◽  
M A Onoja ◽  
...  
Keyword(s):  
Cord Blood ◽  
Umbilical Cord ◽  
Reference Values ◽  
Umbilical Cord Blood ◽  
Blood Count ◽  
Haemoglobin Concentration ◽  
Haematological Parameters ◽  
White Blood Count ◽  
Reference Ranges ◽  
Distribution Method

Umbilical cord blood (UCB) which is useful in supportive and definitive management of inherited and acquired disorders is usually discarded in our environment. We sought to establish reference values for some haematological parameters of UCB in Makurdi, Nigeria to assist clinicians better interpret results of haematological parameters of UCB. This was a prospective quantitative study that involved analyzing UCB of qualified women to determine its complete blood count, fetal haemoglobin concentration, clotting profile and fibrinogen concentration. Reference ranges of these parameters were thereafter calculated using normal distribution method. The effects of maternal and fetal factors on these parameters were assessed using the Student t-test and ANOVA. The mean total white blood count (TWBC) was 12.3±3.7 x 109/L. Female births had significantly higher TWBC than male births (13.2 ± 3.3 x 109/L vs 11.0 ± 3.8 x 109/L, p=0.003). Babies that weighed 3.0-3.5kg also had significantly higher TWBC (18.9x109L) than those that weighed 2.4-2.9kg (8.7x109/L) p=0.010.Female births had significantly higher haemoglobin concentration (Hb) (13.9g/dl) than male births (11.9g/dl) p=0.001. Similarly, older women aged 32-41 years had significantly higher Hb (13.4g/dl) than those aged 18-24 years (11.6g/dl) p=0.002. Also, women that had more than two children had higher Hb than those who had one or two, (14.7g/dl vs 12.3g/dl) p=0.030. Babies that weighed 3.0-3.5kg at birth also had significantly higher Hb (16.2g/dl) than babies that weighed 2.4-2.9kg (12.3g/dl), p=0.003.The reference values of the haematological parameters of cord blood in our study were similar to what was reported from other developing countries. This study has provided data on haematological parameters of UCB for clinical use in our environment and we recommend routine UCB analysis in order to aid early detection of some inherited and congenital disorder.

scholarly journals Umbilical cord blood nucleated red cell count as a marker of perinatal asphyxia

2018 ◽  
Vol 5 (3) ◽  
pp. 701
Author(s):  
Manisha Chavan ◽  
Pratibha M. Patil ◽  
Vijay Bagali
Keyword(s):  
Cord Blood ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Ph Value ◽  
Perinatal Asphyxia ◽  
Surrogate Marker ◽  
Stage Ii ◽  
Stage Iii ◽  
Common Observation ◽  
One Year

Background: Nucleated RBCs are a common observation in the circulating blood of newborn. Number of nRBC in cord blood and perinatal asphyxia shows good correlation. Perinatal asphyxia ranks as the second most important cause of neonatal death after infections accounting for about 30% mortality worldwide. Objective of the present study was designed to find the relation between umbilical cord blood nRBC count and perinatal asphyxia.Methods: The present one-year prospective case control study was carried out. A total of 100 babies divided into two groups of 50 each as cases and controls. Term babies with perinatal asphyxia were enrolled as cases and term babies without perinatal asphyxia born during same period were included as control.Results: The distribution of cord blood pH in cases showed maximum babies (80%) with pH value of <7 and 38% of the children were detected to have HIE stage II followed by 26% with stage I and 4% with stage III. At admission, 48 hours and 72 hours, significantly higher number of babies were found to have higher cord blood nRBC count (p<0.001) and the mean cord blood nRBC count was found to be significantly high at all the intervals (p <0.001). Comparison of mean cord blood nRBC count among cases in stage III was significantly high compared to stage II and I (p<0.001) at admission, 48 hours and 72 hours.Conclusions: Cord blood nRBC can be used as surrogate marker for asphyxia. The clearance of nRBC from the circulation may be of help in prognosticating the outcome of asphyxiated babies. 

scholarly journals Reference Ranges for Hematological Values in Umbilical Cord Blood in Pokhara, Nepal

2016 ◽  
Vol 36 (2) ◽  
pp. 160-164 ◽  
Author(s):  
Sahisnuta Basnet ◽  
Sandip Kumar Singh ◽  
Brijesh Sathian ◽  
Rajnish Mishra
Keyword(s):  
Blood Cell ◽  
Cord Blood ◽  
Cell Count ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Blood Count ◽  
Complete Blood Count ◽  
Reference Ranges ◽  
Blood Cell Count ◽  
Hematological Values

Correction: Due to an error in loading the metadata, the author Sahisnuta Basnet was omitted. Sahisnuta Basnet was therefore added to the metadata on 9th January 2017. The PDF was correct.Introduction: Reference hematological values in newborns are informative in evaluation of newborns to determine state of health or disease. For a given population, reference values may differ in accordance with various factors such as age, sex, race, diet, drug intake, altitude, socio-economic status and also the method employed for determination of the values. The aim of this study was to establish reference ranges of complete blood count using umbilical cord blood of normal, healthy, full term neonates born in Manipal Teaching Hospital (MTH), Pokhara, Nepal.Material and Method: The study was conducted in 210 full term, healthy newborns delivered in MTH between Jan 2014 to Feb 2015. Cord blood was collected and a complete blood count was obtained using an automated hematology analyzer.Result: Mean hemoglobin was 15.24 ± 1.96 gm/dl and mean red blood cell count was 4.30 ± 0.63 (range 3.05 – 6.36) X 1012/L. Mean white blood cell count was 14.93 ± 4.44 (range 6.10 ± 31.7) X 109/L and platelet count was 226.88 ± 61.28 (range 105 ± 392) X 109/L. There was no significant difference found in hemoglobin, red cell, white cell and platelet counts between males and females in this study.Conclusion: The values obtained from our study provide ranges for some hematological values in healthy newborns of Pokhara Nepal. However, the hematological reference values for Nepalese cord blood needs to be confirmed by larger numbers of samples from different centers of Nepal.J Nepal Paediatr Soc 2016;36(2):160-164.

scholarly journals Laboratory Characteristics of Umbilical Cord Blood in Makurdi North-Central Nigeria

2018 ◽  
Vol 1 (4) ◽  
pp. 228-233
Author(s):  
A I Nwannadi ◽  
T Z Swende ◽  
O O Alao ◽  
H I Aba ◽  
M A Onoja ◽  
...  
Keyword(s):  
Cord Blood ◽  
Umbilical Cord ◽  
Reference Values ◽  
Umbilical Cord Blood ◽  
Blood Count ◽  
Haemoglobin Concentration ◽  
Haematological Parameters ◽  
White Blood Count ◽  
Reference Ranges ◽  
Distribution Method

Umbilical cord blood (UCB) which is useful in supportive and definitive management of inherited and acquired disorders is usually discarded in our environment. We sought to establish reference values for some haematological parameters of UCB in Makurdi, Nigeria to assist clinicians better interpret results of haematological parameters of UCB. This was a prospective quantitative study that involved analyzing UCB of qualified women to determine its complete blood count, fetal haemoglobin concentration, clotting profile and fibrinogen concentration. Reference ranges of these parameters were thereafter calculated using normal distribution method. The effects of maternal and fetal factors on these parameters were assessed using the Student t-test and ANOVA. The mean total white blood count (TWBC) was 12.3±3.7 x 109/L. Female births had significantly higher TWBC than male births (13.2 ± 3.3 x 109/L vs 11.0 ± 3.8 x 109/L, p=0.003). Babies that weighed 3.0-3.5kg also had significantly higher TWBC (18.9x109L) than those that weighed 2.4-2.9kg (8.7x109/L) p=0.010.Female births had significantly higher haemoglobin concentration (Hb) (13.9g/dl) than male births (11.9g/dl) p=0.001. Similarly, older women aged 32-41 years had significantly higher Hb (13.4g/dl) than those aged 18-24 years (11.6g/dl) p=0.002. Also, women that had more than two children had higher Hb than those who had one or two, (14.7g/dl vs 12.3g/dl) p=0.030. Babies that weighed 3.0-3.5kg at birth also had significantly higher Hb (16.2g/dl) than babies that weighed 2.4-2.9kg (12.3g/dl), p=0.003.The reference values of the haematological parameters of cord blood in our study were similar to what was reported from other developing countries. This study has provided data on haematological parameters of UCB for clinical use in our environment and we recommend routine UCB analysis in order to aid early detection of some inherited and congenital disorder.

One Less Painful Procedure: Using Umbilical Cord Blood as Alternative Source to Admission Complete Blood Count

2017 ◽  
Vol 34 (12) ◽  
pp. 1178-1184 ◽  
Author(s):  
Neera Prakash ◽  
Joseph Decristofaro ◽  
Echezona Maduekwe
Keyword(s):  
Blood Cell ◽  
Cord Blood ◽  
Preterm Infants ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Gestational Age ◽  
Blood Count ◽  
Complete Blood Count ◽  
Late Preterm ◽  
Late Preterm Infants

Objective This study aims to evaluate the use of umbilical cord blood as an alternative to the admission complete blood count (CBC) in the well-appearing late preterm neonates admitted to the neonatal intensive care unit. Study Design Paired umbilical cord and admission blood CBC samples from well late preterm infants were compared using a two-sample t-test or analysis of variance with an unequal variance for differences in the hemoglobin, platelet counts, white blood cell, and absolute neutrophil counts. Results A total of 100 infants were enrolled in the study. The study included 46 females, 5 Asian, 9 Black, 35 Hispanic, 51 White, with a mean gestational age of 35.3 ± 1 weeks (range: 34–36.5 weeks), and a mean birth weight of 2,347 ± 491 g (range: 1,840–4,260 g). Around 80% were appropriate for gestational age, 5% were large for gestational age, and 15% were small for gestational age. The median difference between the cord and admission blood samples were hemoglobin: 1.1 g/dL, platelet: 7.50 × 103 cells/μL, white blood cell count: 2.3 × 103 cells/μL, and absolute neutrophil count: 0.6 × 103 cells/μL. Conclusion The cord and admission blood testing were not statistically or clinically different when compared. In well late preterm infants, the NICU admission blood CBC may be replaced with an umbilical cord blood CBC.

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