scholarly journals The Effects of Complete Blood Count and Ferritin Values from the Mother and the Umbilical Cord Blood on the Infant’s Anemia at the 4th Month and Neurodevelopment at the 6th Month

2019 ◽  
Author(s):  
Serpil Ece ARAS ÖZTÜRK ◽  
Selma AKTAŞ ◽  
Salih GÖZMEN ◽  
Zeynep İLKSEN YILMAZ ◽  
Canan VERGİN
Keyword(s):  
Cord Blood ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Blood Count ◽  
Complete Blood Count

scholarly journals Reference Ranges for Hematological Values in Umbilical Cord Blood in Pokhara, Nepal

2016 ◽  
Vol 36 (2) ◽  
pp. 160-164 ◽  
Author(s):  
Sahisnuta Basnet ◽  
Sandip Kumar Singh ◽  
Brijesh Sathian ◽  
Rajnish Mishra
Keyword(s):  
Blood Cell ◽  
Cord Blood ◽  
Cell Count ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Blood Count ◽  
Complete Blood Count ◽  
Reference Ranges ◽  
Blood Cell Count ◽  
Hematological Values

Correction: Due to an error in loading the metadata, the author Sahisnuta Basnet was omitted. Sahisnuta Basnet was therefore added to the metadata on 9th January 2017. The PDF was correct.Introduction: Reference hematological values in newborns are informative in evaluation of newborns to determine state of health or disease. For a given population, reference values may differ in accordance with various factors such as age, sex, race, diet, drug intake, altitude, socio-economic status and also the method employed for determination of the values. The aim of this study was to establish reference ranges of complete blood count using umbilical cord blood of normal, healthy, full term neonates born in Manipal Teaching Hospital (MTH), Pokhara, Nepal.Material and Method: The study was conducted in 210 full term, healthy newborns delivered in MTH between Jan 2014 to Feb 2015. Cord blood was collected and a complete blood count was obtained using an automated hematology analyzer.Result: Mean hemoglobin was 15.24 ± 1.96 gm/dl and mean red blood cell count was 4.30 ± 0.63 (range 3.05 – 6.36) X 1012/L. Mean white blood cell count was 14.93 ± 4.44 (range 6.10 ± 31.7) X 109/L and platelet count was 226.88 ± 61.28 (range 105 ± 392) X 109/L. There was no significant difference found in hemoglobin, red cell, white cell and platelet counts between males and females in this study.Conclusion: The values obtained from our study provide ranges for some hematological values in healthy newborns of Pokhara Nepal. However, the hematological reference values for Nepalese cord blood needs to be confirmed by larger numbers of samples from different centers of Nepal.J Nepal Paediatr Soc 2016;36(2):160-164.

One Less Painful Procedure: Using Umbilical Cord Blood as Alternative Source to Admission Complete Blood Count

2017 ◽  
Vol 34 (12) ◽  
pp. 1178-1184 ◽  
Author(s):  
Neera Prakash ◽  
Joseph Decristofaro ◽  
Echezona Maduekwe
Keyword(s):  
Blood Cell ◽  
Cord Blood ◽  
Preterm Infants ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Gestational Age ◽  
Blood Count ◽  
Complete Blood Count ◽  
Late Preterm ◽  
Late Preterm Infants

Objective This study aims to evaluate the use of umbilical cord blood as an alternative to the admission complete blood count (CBC) in the well-appearing late preterm neonates admitted to the neonatal intensive care unit. Study Design Paired umbilical cord and admission blood CBC samples from well late preterm infants were compared using a two-sample t-test or analysis of variance with an unequal variance for differences in the hemoglobin, platelet counts, white blood cell, and absolute neutrophil counts. Results A total of 100 infants were enrolled in the study. The study included 46 females, 5 Asian, 9 Black, 35 Hispanic, 51 White, with a mean gestational age of 35.3 ± 1 weeks (range: 34–36.5 weeks), and a mean birth weight of 2,347 ± 491 g (range: 1,840–4,260 g). Around 80% were appropriate for gestational age, 5% were large for gestational age, and 15% were small for gestational age. The median difference between the cord and admission blood samples were hemoglobin: 1.1 g/dL, platelet: 7.50 × 103 cells/μL, white blood cell count: 2.3 × 103 cells/μL, and absolute neutrophil count: 0.6 × 103 cells/μL. Conclusion The cord and admission blood testing were not statistically or clinically different when compared. In well late preterm infants, the NICU admission blood CBC may be replaced with an umbilical cord blood CBC.

scholarly journals Reference intervals for complete blood count from Umbilical Cord Blood in newborns and comparison with Venous Blood Values

2021 ◽  
Vol 37 (2) ◽  
Author(s):  
Mehmet Gündüz ◽  
Hayrettin Temel
Keyword(s):  
Cord Blood ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Blood Count ◽  
Complete Blood Count ◽  
Hematological Parameters ◽  
Clinical Status ◽  
Venous Blood ◽  
Reference Intervals ◽  
Blood Samples

Background and Objective: Umbilical cord blood which can be obtained by a non-invasive method can be informative about the clinical status of the newborn. It was aimed to establish reference intervals for umbilical cord blood parameters, and to compare complete blood count results between umbilical cord and venous blood samples in this study. Methods: This study was conducted at Medipol University Sefaköy Hospital, Department of Pediatrics, Istanbul, Turkey. A total of 1898 newborns who were born in a two-year period between January 2018 and December 2019 were included in the study. Venous blood samples were taken from 184 of them, and umbilical cord blood samples were taken from 1714 newborns. Results: The percentiles were determined according to gender and delivery method for the hematological parameters of umbilical cord blood. While mean platelet, eosinophil and mean corpuscular volume values ​​were similar between the groups (p>0.05 for each), and significant differences were found between the groups in terms of all other mean hematological parameters ​​(p<0.05 for each). Conclusion: The results of the complete blood count of umbilical cord blood samples can provide reliable information about the newborn. There are significant differences between umbilical cord and venous blood samples in terms of hematological parameters. For these reasons, it is necessary to determine reliable value ranges for umbilical cord blood hematological parameters in newborns. Data of our study can be a guide for further studies and clinicians. doi: https://doi.org/10.12669/pjms.37.2.2526 How to cite this:Gunduz M, Temel H. Reference intervals for complete blood count from Umbilical Cord Blood in newborns and comparison with Venous Blood Values. Pak J Med Sci. 2021;37(2):---------. doi: https://doi.org/10.12669/pjms.37.2.2526 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

scholarly journals Laboratory Characteristics of Umbilical Cord Blood in Makurdi North-Central Nigeria

2018 ◽  
Vol 1 (4) ◽  
pp. 228-233
Author(s):  
A I Nwannadi ◽  
T Z Swende ◽  
O O Alao ◽  
H I Aba ◽  
M A Onoja ◽  
...  
Keyword(s):  
Cord Blood ◽  
Umbilical Cord ◽  
Reference Values ◽  
Umbilical Cord Blood ◽  
Blood Count ◽  
Haemoglobin Concentration ◽  
Haematological Parameters ◽  
White Blood Count ◽  
Reference Ranges ◽  
Distribution Method

Umbilical cord blood (UCB) which is useful in supportive and definitive management of inherited and acquired disorders is usually discarded in our environment. We sought to establish reference values for some haematological parameters of UCB in Makurdi, Nigeria to assist clinicians better interpret results of haematological parameters of UCB. This was a prospective quantitative study that involved analyzing UCB of qualified women to determine its complete blood count, fetal haemoglobin concentration, clotting profile and fibrinogen concentration. Reference ranges of these parameters were thereafter calculated using normal distribution method. The effects of maternal and fetal factors on these parameters were assessed using the Student t-test and ANOVA. The mean total white blood count (TWBC) was 12.3±3.7 x 109/L. Female births had significantly higher TWBC than male births (13.2 ± 3.3 x 109/L vs 11.0 ± 3.8 x 109/L, p=0.003). Babies that weighed 3.0-3.5kg also had significantly higher TWBC (18.9x109L) than those that weighed 2.4-2.9kg (8.7x109/L) p=0.010.Female births had significantly higher haemoglobin concentration (Hb) (13.9g/dl) than male births (11.9g/dl) p=0.001. Similarly, older women aged 32-41 years had significantly higher Hb (13.4g/dl) than those aged 18-24 years (11.6g/dl) p=0.002. Also, women that had more than two children had higher Hb than those who had one or two, (14.7g/dl vs 12.3g/dl) p=0.030. Babies that weighed 3.0-3.5kg at birth also had significantly higher Hb (16.2g/dl) than babies that weighed 2.4-2.9kg (12.3g/dl), p=0.003.The reference values of the haematological parameters of cord blood in our study were similar to what was reported from other developing countries. This study has provided data on haematological parameters of UCB for clinical use in our environment and we recommend routine UCB analysis in order to aid early detection of some inherited and congenital disorder.

Performance evaluation of Sysmex XN hematology analyzer in umbilical cord blood: a comparison study with Sysmex XE-2100

2014 ◽  
Vol 52 (12) ◽  
Author(s):  
Hanah Kim ◽  
Mina Hur ◽  
Sang-Gyeu Choi ◽  
Hee-Won Moon ◽  
Yeo-Min Yun ◽  
...  
Keyword(s):  
Cord Blood ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Blood Cells ◽  
Complete Blood Count ◽  
White Blood Cells ◽  
Modular System ◽  
Hematopoietic Stem ◽  
Nucleated Red Blood Cells ◽  
Hematology Analyzer

AbstractThe Sysmex XN (XN) modular system (Sysmex, Kobe, Japan) is a new automated hematology analyzer equipped with different principles from its previous version, Sysmex XE-2100. We compared the performances of Sysmex XN and XE-2100 in umbilical cord blood (CB) specimens.In 160 CB specimens, complete blood count (CBC) parameters and white blood cells (WBC) differentials were compared between the two analyzers. Their flagging performances for blasts, abnormal/atypical lymphocytes, immature granulocytes and/or left-shift (IG), and nucleated red blood cells (NRBC) counts were compared with manual counts. For the blast flagging, Q values by Sysmex XN were further compared with manual slide review.Sysmex XN and XE-2100 showed high or very high correlations for most CBC parameters but variable correlations for WBC differentials. Compared with XE-2100, XN showed significantly different flagging performances for blasts, abnormal/atypical lymphocytes, and IG. The flagging efficiency for blasts was significantly better on Sysmex XN than on XE-2100 (85.0% vs. 38.8%): Sysmex XN showed a remarkably increased specificity of blast flag, compromising its sensitivity of blast flag. Among the 24 specimens with blasts (range, 0.5%–1.5%), only one (4.2%) showed a positive Q value.This study highlighted the remarkable differences of flagging performances between Sysmex XN and XE-2100 in CB specimens. The Sysmex XN modular system seems to be a suitable and practical option for the CB specimens used for hematopoietic stem cell transplantation as well as for the specimens from neonates.

scholarly journals Laboratory Characteristics of Umbilical Cord Blood in Makurdi North-Central Nigeria

2018 ◽  
Vol 1 (4) ◽  
pp. 228-233
Author(s):  
A I Nwannadi ◽  
T Z Swende ◽  
O O Alao ◽  
H I Aba ◽  
M A Onoja ◽  
...  
Keyword(s):  
Cord Blood ◽  
Umbilical Cord ◽  
Reference Values ◽  
Umbilical Cord Blood ◽  
Blood Count ◽  
Haemoglobin Concentration ◽  
Haematological Parameters ◽  
White Blood Count ◽  
Reference Ranges ◽  
Distribution Method

Umbilical cord blood (UCB) which is useful in supportive and definitive management of inherited and acquired disorders is usually discarded in our environment. We sought to establish reference values for some haematological parameters of UCB in Makurdi, Nigeria to assist clinicians better interpret results of haematological parameters of UCB. This was a prospective quantitative study that involved analyzing UCB of qualified women to determine its complete blood count, fetal haemoglobin concentration, clotting profile and fibrinogen concentration. Reference ranges of these parameters were thereafter calculated using normal distribution method. The effects of maternal and fetal factors on these parameters were assessed using the Student t-test and ANOVA. The mean total white blood count (TWBC) was 12.3±3.7 x 109/L. Female births had significantly higher TWBC than male births (13.2 ± 3.3 x 109/L vs 11.0 ± 3.8 x 109/L, p=0.003). Babies that weighed 3.0-3.5kg also had significantly higher TWBC (18.9x109L) than those that weighed 2.4-2.9kg (8.7x109/L) p=0.010.Female births had significantly higher haemoglobin concentration (Hb) (13.9g/dl) than male births (11.9g/dl) p=0.001. Similarly, older women aged 32-41 years had significantly higher Hb (13.4g/dl) than those aged 18-24 years (11.6g/dl) p=0.002. Also, women that had more than two children had higher Hb than those who had one or two, (14.7g/dl vs 12.3g/dl) p=0.030. Babies that weighed 3.0-3.5kg at birth also had significantly higher Hb (16.2g/dl) than babies that weighed 2.4-2.9kg (12.3g/dl), p=0.003.The reference values of the haematological parameters of cord blood in our study were similar to what was reported from other developing countries. This study has provided data on haematological parameters of UCB for clinical use in our environment and we recommend routine UCB analysis in order to aid early detection of some inherited and congenital disorder.

scholarly journals Laboratory Characteristics of Umbilical Cord Blood in Makurdi North-Central Nigeria

2018 ◽  
Vol 1 (4) ◽  
pp. 228-233
Author(s):  
A I Nwannadi ◽  
T Z Swende ◽  
O O Alao ◽  
H I Aba ◽  
M A Onoja ◽  
...  
Keyword(s):  
Cord Blood ◽  
Umbilical Cord ◽  
Reference Values ◽  
Umbilical Cord Blood ◽  
Blood Count ◽  
Haemoglobin Concentration ◽  
Haematological Parameters ◽  
White Blood Count ◽  
Reference Ranges ◽  
Distribution Method

Umbilical cord blood (UCB) which is useful in supportive and definitive management of inherited and acquired disorders is usually discarded in our environment. We sought to establish reference values for some haematological parameters of UCB in Makurdi, Nigeria to assist clinicians better interpret results of haematological parameters of UCB. This was a prospective quantitative study that involved analyzing UCB of qualified women to determine its complete blood count, fetal haemoglobin concentration, clotting profile and fibrinogen concentration. Reference ranges of these parameters were thereafter calculated using normal distribution method. The effects of maternal and fetal factors on these parameters were assessed using the Student t-test and ANOVA. The mean total white blood count (TWBC) was 12.3±3.7 x 109/L. Female births had significantly higher TWBC than male births (13.2 ± 3.3 x 109/L vs 11.0 ± 3.8 x 109/L, p=0.003). Babies that weighed 3.0-3.5kg also had significantly higher TWBC (18.9x109L) than those that weighed 2.4-2.9kg (8.7x109/L) p=0.010.Female births had significantly higher haemoglobin concentration (Hb) (13.9g/dl) than male births (11.9g/dl) p=0.001. Similarly, older women aged 32-41 years had significantly higher Hb (13.4g/dl) than those aged 18-24 years (11.6g/dl) p=0.002. Also, women that had more than two children had higher Hb than those who had one or two, (14.7g/dl vs 12.3g/dl) p=0.030. Babies that weighed 3.0-3.5kg at birth also had significantly higher Hb (16.2g/dl) than babies that weighed 2.4-2.9kg (12.3g/dl), p=0.003.The reference values of the haematological parameters of cord blood in our study were similar to what was reported from other developing countries. This study has provided data on haematological parameters of UCB for clinical use in our environment and we recommend routine UCB analysis in order to aid early detection of some inherited and congenital disorder.

Pilot Clinical Study Incorporating Hyperbaric Oxygen into Umbilical Cord Blood Transplantation

Blood ◽  
2014 ◽  
Vol 124 (21) ◽  
pp. 3889-3889
Author(s):  
Omar S. Aljitawi ◽  
Siddhartha Ganguly ◽  
Tara L. Lin ◽  
Shana L Palla ◽  
Lominska Chris ◽  
...  
Keyword(s):  
Platelet Count ◽  
Cord Blood ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Blood Count ◽  
Cord Blood Transplantation ◽  
Blood Transplantation ◽  
Reduced Intensity ◽  
Grade Iii ◽  
Count Recovery

Abstract Background: Umbilical cord blood (UCB) is a rich source of hematopoietic stem cells and may be the only allogeneic transplant option for some patients with hematologic malignancies. However, UCB transplantation is associated with delayed blood count recovery and engraftment. In preclinical studies, we have demonstrated that hyperbaric oxygen (HBO) therapy, given prior to cytokine expanded and gene-transduced UCB CD34+ cell infusion, improves peripheral blood, bone marrow, and spleen engraftment in a murine model. Based on these results, we started a pilot clinical trial primarily investigating the safety of HBO in the setting of UCB transplantation. Secondarily, we are evaluating the time to neutrophil and platelet count recovery and engraftment.As a potential marker for effective HBO therapy, we also evaluated serum erythropoietin (EPO) levels in transplanted patients prior to HBO therapy and again at time of transplantation. Materials/methods: Patients with hematological malignancies that require UCB transplantation, either reduced intensity or myeloablative, were included. On day 0, patients received HBO treatment consisting of exposure to 2.5 atmosphere absolutes for a total of 2 hours, in a single hyperbaric chamber, breathing 100% oxygen. Six hours from the start of HBO, single or double UCB units were infused and patients were followed daily for toxicity and blood count recovery. Serum EPO levels were measured by enzyme-linked immunosorbent assay (ELISA). Results: 18 patients were screened for this study, 9 were enrolled, and 9 were treated. The treated subjects were 5 males (56%) and 4 females (44%) with median age of 44 (23-70) who had acute myeloid leukemia (n=6), non-Hodgkin’s lymphoma (n=1), and acute lymphoblastic leukemia (n=2); all patients were in first (n=8) or second (n=1) complete remission. All but two patients received one UCB unit with a median total nucleated cell dose of 3.3 (2.7-4.5) ×107 /Kg recipient body weight and 6 of 9 patients received reduced intensity conditioning. All treated patients completed the planned therapy without a treatment limiting toxicity defined as the occurrence of any of the following complications within 24 hours of HBO: seizure disorder, pneumothorax, death or irreversible grade III or any grade IV toxicity that is determined by the treating physician to be, at least, likely related to HBO therapy. None of the patients experienced an unexpected toxicity. All patients engrafted except for one patient who demonstrated prompt autologous blood count recovery. Platelet count recovery was not assessable in one patient. Time to neutrophil count recovery (defined as the first of 3 consecutive days of an absolute neutrophil count (ANC) of greater than 500/μL) and time to platelet count recovery (defined as the first day of a sustained platelet count greater than 20 K/UL) were 16 (6-25) and 32 (8-87), respectively. 90% or higher donor chimerism was documented in peripheral blood/bone marrow of engrafted patients receiving reduced intensity regimen at a median of 18 (15-31) days post-transplant. Six of the 9 (67%) patients developed acute graft versus host disease at time of engraftment; 50% developed grade I, 33% had grade II and 17% had grade III. In 7 patients who had serum EPO levels assessed, median EPO levels at time of UCB infusion were lower than their median levels prior to HBO therapy (11.3 vs. 25.2 mU/mL). Conclusions: HBO therapy prior to UCB cell infusion appears to be well-tolerated in the setting of clinical umbilical cord blood transplantation. Time to neutrophil recovery/engraftment as well as platelet count recovery appear to be encouraging. HBO therapy resulted in lower EPO serum levels at time of UCB infusion. Disclosures No relevant conflicts of interest to declare.

THE CORRELATION BETWEEN PARAMETERS OF UMBILICAL CORD BLOOD COUNT AND BRAIN DAMAGE IN NEWBORNS WITH PERINATAL ASPHYXIA

2014 ◽  
Vol 42 (1) ◽  
Author(s):  
Amela Selimović ◽  
Fahrija Skokić ◽  
Selma Muratović ◽  
Selmira Brkić ◽  
Nermina Dedić ◽  
...  
Keyword(s):  
Cord Blood ◽  
Brain Damage ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Blood Count ◽  
Perinatal Asphyxia
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