Pseudoangiomatous stromal hyperplasia causing severe breast enlargement in a 15-year-old girl

Author(s):  
Banu Yigit ◽  
Bülent Citgez ◽  
Mustafa Celayir ◽  
Sıtkı Yetkin ◽  
Canan Tanık ◽  
...  
2017 ◽  
Vol 2017 ◽  
pp. 1-6 ◽  
Author(s):  
Isabel Sollozo-Dupont ◽  
Héctor Alejandro Domínguez-Hernández ◽  
Cecilia Pavón-Hernández ◽  
Yolanda Villaseñor-Navarro ◽  
Robin Shaw-Dulin ◽  
...  

The incidence of reported pseudoangiomatous stromal hyperplasia (PASH), as well as the variability and severity of clinical presentations, is increasing in the literature. In parallel, several authors posit the need for an improved classification of PASH to avoid possible variables associated with this diagnosis. Here, we present a 25-year-old woman with PASH accompanied by severe bilateral and symmetrical breasts enlargement, highlighting an uncommon clinical presentation of PASH as much as the careful interdisciplinary review and correlation of histology and all available imaging studies to confirm the definitive diagnosis.


2015 ◽  
pp. bcr2014204343 ◽  
Author(s):  
Anita Geraldine Bourke ◽  
Stephen Tiang ◽  
Nathan Harvey ◽  
Robert McClure

2016 ◽  
Vol 43 (2) ◽  
pp. 218-221 ◽  
Author(s):  
Jeong Woo Lee ◽  
Gyu Sik Jung ◽  
Jae Bong Kim ◽  
Kang Young Choi ◽  
Ho Yun Chung ◽  
...  

Breast Care ◽  
2016 ◽  
Vol 11 (5) ◽  
pp. 356-358 ◽  
Author(s):  
Natalia Krawczyk ◽  
Tanja Fehm ◽  
Eugen Ruckhäberle ◽  
Svjetlana Mohrmann ◽  
Jasmin Riemer ◽  
...  

Pseudoangiomatous stromal hyperplasia (PASH) is a benign proliferation of mammary stroma mostly described as an incidental microscopic finding. Clinically, it can manifest as a palpable, well-circumscribed breast mass or in rare cases as a diffuse bilateral process causing massive breast enlargement. The most postulated theory for aetiology of this condition is hormonal stimulation of mammary myofibroblasts, particularly by progesterone. A definite diagnosis of PASH is based on typical pathological findings like stromal hyperplasia and empty slit-like channels positive for myofibroblastic and negative for endothelial markers. The main clinical differential diagnosis is a fibroadedoma or phylloid tumour, and histologically a low-grade angiosarcoma. There are less than 200 cases of tumorous PASH and less than 20 of diffuse PASH reported so far. Here we present a case report of huge diffuse PASH, that is, to our knowledge, the first in a pregnant woman.


2016 ◽  
Vol 2016 ◽  
pp. 1-4 ◽  
Author(s):  
Afsaneh Alikhassi ◽  
Fereshteh Ensani ◽  
Ramesh Omranipour ◽  
Alireza Abdollahi

Pseudoangiomatous stromal hyperplasia (PASH) of the breast is a pathology that is usually diagnosed by accident during pathological examination of other breast lesions. PASH is an uncommon and benign tumoral lesion of the mammary stroma that can be pathologically mistaken for other tumours, such as phyllodes, fibroadenoma, and sometimes even angiosarcoma. We report the case of a 45-year-old woman with complaints of huge bilateral breast enlargement. This is a rare case of PASH presenting with gigantomastia and involving bilateral breasts and axillae simultaneously. Mammography, ultrasonography, and MRI features are illustrated with histopathological correlation.


2012 ◽  
Vol 18 (6) ◽  
pp. 600-601 ◽  
Author(s):  
Karen S. Johnson ◽  
Rex C. Bentley ◽  
P. Kelly Marcom ◽  
Jay A. Baker

2014 ◽  
Vol 17 (4) ◽  
pp. 224
Author(s):  
Yue-Dong Shi ◽  
Fa-Zhi Qi ◽  
Zi-Hao Feng

We report a bilateral reduction mammoplasty in a 15 year old female who suffered increasing back and shoulder pain and chest wall discomfort associated with bilateral breast enlargement during a 17 month period following heart transplantation. Cardiologic evaluation confirmed a structurally normal heart with good systolic and diastolic function, and ejection fraction of 80%. We performed a bilateral mammoplasty using dermal suspension flap in vertical-scar reduction. The patient recovered satisfactorily without incident, and breast morphology was excellent at the 2 year 9 month follow-up, with no recurrence of her previous symptoms or further hyperplasia.


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