scholarly journals An Uncommon Case of Bilateral Breast Enlargement Diagnosed as Tumoral Pseudoangiomatous Stromal Hyperplasia: Imaging and Pathological Findings

2017 ◽  
Vol 2017 ◽  
pp. 1-6 ◽  
Author(s):  
Isabel Sollozo-Dupont ◽  
Héctor Alejandro Domínguez-Hernández ◽  
Cecilia Pavón-Hernández ◽  
Yolanda Villaseñor-Navarro ◽  
Robin Shaw-Dulin ◽  
...  
Keyword(s):  
Clinical Presentation ◽  
Definitive Diagnosis ◽  
Pathological Findings ◽  
Imaging Studies ◽  
Pseudoangiomatous Stromal Hyperplasia ◽  
Breast Enlargement ◽  
Clinical Presentations ◽  
Uncommon Case ◽  
Bilateral Breast Enlargement

The incidence of reported pseudoangiomatous stromal hyperplasia (PASH), as well as the variability and severity of clinical presentations, is increasing in the literature. In parallel, several authors posit the need for an improved classification of PASH to avoid possible variables associated with this diagnosis. Here, we present a 25-year-old woman with PASH accompanied by severe bilateral and symmetrical breasts enlargement, highlighting an uncommon clinical presentation of PASH as much as the careful interdisciplinary review and correlation of histology and all available imaging studies to confirm the definitive diagnosis.

The patient with vasculitis

2015 ◽  
Author(s):  
David Jayne
Keyword(s):  
Clinical Presentation ◽  
Renal Involvement ◽  
Disease Process ◽  
Small Vessel Vasculitis ◽  
Clinical Presentations ◽  
Severe Manifestation ◽  
Definition Of ◽  
End Stage ◽  
Autoimmune Aetiology

The definition of vasculitis syndromes relies on clinical, serological, and pathological descriptions. A number of primary syndromes are recognized, of presumed autoimmune aetiology, but vasculitis may also occur as a secondary disease process. The heterogeneity of clinical presentation, low specificity of many clinical features, and mimics of other diseases complicate vasculitis diagnosis. The kidney is the most common severe manifestation for small vessel vasculitis syndromes and the severity of renal involvement predicts end-stage renal failure risk and death. Suspicion of vasculitis is key to early diagnosis and improving outcomes of vasculitis patients.The current understanding of the classification of vasculitis syndromes is presented in this chapter along with descriptions of clinical presentations, and approaches to diagnosis.

scholarly journals Adrenal  gland tumours. Different clinical presentations in three dogs: a case report

2013 ◽  
Vol 58 (No. 7) ◽  
pp. 377-384
Author(s):  
A. Loste ◽  
M. Borobia ◽  
M. Borobia ◽  
D. Lacasta ◽  
M. Carbonell ◽  
...  
Keyword(s):  
Adrenal Gland ◽  
Clinical Presentation ◽  
Imaging Techniques ◽  
Clinical Signs ◽  
Metastatic Lesion ◽  
Adrenocortical Adenoma ◽  
Imaging Studies ◽  
Clinical Presentations ◽  
Different Types ◽  
Diagnostic Imaging Techniques

Three dogs were evaluated due to the presence of unilateral adrenal gland masses with or without clinical signs. Case 1 showed a unilateral non-functional adrenocortical adenoma, discovered accidentally while Case 2 presented a unilateral cortisol-secreting adrenocortical adenoma; a pheochromocytoma was accidentally discovered in Case 3. The adrenalectomy was the treatment of choice in all cases. The development of diagnostic imaging techniques, mainly ultrasonography, and its application to routine abdominal examinations, have allowed the detection of adrenal gland masses more frequently. However, there is no pattern of echogenicity or architecture which would help in the differentiation in a functional tumour from a non-functional tumour, a pheochromocytoma, a metastatic lesion to the adrenal or a granuloma. A complete description of history, clinical signs, laboratory analysis and imaging studies is included. Moreover, a revision of the different types of adrenal gland tumours, with their clinical presentation, a standardised diagnosis protocol and options for treatment are discussed.  

Osteonecrosis of Interphalangeal Joint of Thumb Two Months after Rattlesnake Bite

Hand Surgery ◽  
2015 ◽  
Vol 20 (02) ◽  
pp. 330-332 ◽  
Author(s):  
Patrick Bonasso ◽  
Brandon Lucke-Wold ◽  
Glen Jacob
Keyword(s):  
Clinical Presentation ◽  
Operative Management ◽  
Definitive Diagnosis ◽  
Interphalangeal Joint ◽  
Review Of Literature ◽  
Imaging Studies ◽  
Unique Challenge ◽  
X Ray ◽  
One Year ◽  
Pathology Review

This case report details the osteonecrosis of the interphalangeal (IP) joint of the thumb two months after a rattlesnake bite. It describes the clinical presentation, imaging studies, histological review, pathology review, and review of literature. Our patient was a fifty-one year-old male who obtained a poisonous snakebite to the thumb. While in the hospital for acute treatment, a blood blister was debrided. He was seen two weeks after discharge for further debridement of epidermolysis. Patient presented one month later with a hand x-ray demonstrating bony erosions, and a bone scan showing active changes in the IP joint of his right thumb. He was taken to the OR for further debridement and definitive diagnosis. Pathology results confirmed osteonecrosis with negative bone cultures. The clinical presentation, diagnosis, and operative management of osteonecrosis offer a unique challenge, especially in a patient presenting with osteonecrosis from a poisonous snakebite.

Clinical-Pathological Correlates of Congenital Subglottic Hemangiomas

1983 ◽  
Vol 92 (4_suppl) ◽  
pp. 4-18 ◽  
Author(s):  
Nina Yoshpe ◽  
Linda Brodsky ◽  
Robert J. Ruben
Keyword(s):  
English Language ◽  
Clinical Presentation ◽  
Diagnosis And Treatment ◽  
Pathological Findings ◽  
Laryngeal Pathology ◽  
English Language Literature ◽  
Clinical Presentations ◽  
Diagnostic Work ◽  
Language Literature

One hundred thirty-six cases of subglottic hemangioma in infants have been reported in the English -language literature; four additional cases are reported here. The clinical presentations, diagnostic work-ups, treatments, and outcomes are analyzed. Twenty-one patients died, 17 of whom underwent autopsy. The histology of the laryngeal pathology from seven of these patients was reviewed by the authors. Possible correlation between the pathological findings and the clinical presentation is made. Approaches to diagnosis and treatment are suggested based on these findings.

scholarly journals Pseudoangiomatous Stromal Hyperplasia Presenting as Rapidly Growing Bilateral Breast Enlargement Refractory to Surgical Excision

2016 ◽  
Vol 43 (2) ◽  
pp. 218-221 ◽  
Author(s):  
Jeong Woo Lee ◽  
Gyu Sik Jung ◽  
Jae Bong Kim ◽  
Kang Young Choi ◽  
Ho Yun Chung ◽  
...  
Keyword(s):  
Surgical Excision ◽  
Pseudoangiomatous Stromal Hyperplasia ◽  
Breast Enlargement ◽  
Bilateral Breast Enlargement

scholarly journals Bilateral Diffuse Pseudoangiomatous Stromal Hyperplasia (PASH) Causing Gigantomastia in a 33-Year-Old Pregnant Woman: Case Report

Breast Care ◽  
2016 ◽  
Vol 11 (5) ◽  
pp. 356-358 ◽  
Author(s):  
Natalia Krawczyk ◽  
Tanja Fehm ◽  
Eugen Ruckhäberle ◽  
Svjetlana Mohrmann ◽  
Jasmin Riemer ◽  
...  
Keyword(s):  
Case Report ◽  
Pregnant Woman ◽  
Low Grade ◽  
Definite Diagnosis ◽  
Pathological Findings ◽  
Hormonal Stimulation ◽  
Pseudoangiomatous Stromal Hyperplasia ◽  
Breast Enlargement ◽  
Clinical Differential Diagnosis ◽  
Stimulation Of

Pseudoangiomatous stromal hyperplasia (PASH) is a benign proliferation of mammary stroma mostly described as an incidental microscopic finding. Clinically, it can manifest as a palpable, well-circumscribed breast mass or in rare cases as a diffuse bilateral process causing massive breast enlargement. The most postulated theory for aetiology of this condition is hormonal stimulation of mammary myofibroblasts, particularly by progesterone. A definite diagnosis of PASH is based on typical pathological findings like stromal hyperplasia and empty slit-like channels positive for myofibroblastic and negative for endothelial markers. The main clinical differential diagnosis is a fibroadedoma or phylloid tumour, and histologically a low-grade angiosarcoma. There are less than 200 cases of tumorous PASH and less than 20 of diffuse PASH reported so far. Here we present a case report of huge diffuse PASH, that is, to our knowledge, the first in a pregnant woman.

Classification of Preterm Birth With Placental Correlates

2018 ◽  
Vol 21 (6) ◽  
pp. 548-560 ◽  
Author(s):  
Karen M Chisholm ◽  
Mary E Norton ◽  
Anna A Penn ◽  
Amy Heerema-McKenney
Keyword(s):  
Preterm Birth ◽  
Amniotic Fluid ◽  
Preterm Labor ◽  
Clinical Presentation ◽  
Maternal Factors ◽  
Premature Rupture Of Membranes ◽  
Multiple Gestations ◽  
Clinical Presentations ◽  
Preterm Rupture Of Membranes

Premature birth lacks a widely accepted classification that unites features of the clinical presentation with placental pathology. To further explore associations between the clinical categories of preterm birth and placental histology, 109 infants with gestational age <34 weeks and birth weight <2000 g were selected and, based on electronic records, were classified into preterm birth categories of preterm labor, prelabor premature rupture of membranes, preeclampsia, indicated preterm birth for maternal factors (other than preeclampsia), indicated preterm birth for fetal factors, and the clinical diagnosis of abruption. Corresponding placentas were analyzed for gross and microscopic variables, with findings grouped into categories of amniotic fluid infection, lymphocytic inflammation, maternal vascular malperfusion, and fetal vascular malperfusion. Placental features of maternal vascular malperfusion were pervasive in all preterm birth categories and were commonly associated with amniotic fluid infection and lymphocytic inflammation. Features of maternal vascular malperfusion were significantly associated with preterm birth due to preeclampsia, and amniotic fluid infection was highly associated with prelabor preterm rupture of membranes. Findings of lymphocytic inflammation were significantly increased in cases of abruption. Laminar decidual necrosis was present in all cases of abruption. Placentas from multiple gestations had significantly less histologic findings compared to singletons. Given that 75% of placentas demonstrated at least 1 feature of maternal vascular malperfusion despite different clinical presentations, seemingly different pathologies such as ascending amniotic fluid infection or lymphocytic inflammation may be mechanistically related to processes established early in pregnancy. The concept of “uterine ischemia” may be too simplistic to account for all of the changes attributed to maternal vascular malperfusion in the preterm placenta.

scholarly journals Bilateral Simultaneous Pseudoangiomatous Stromal Hyperplasia of the Breasts and Axillae: Imaging Findings with Pathological and Clinical Correlation

2016 ◽  
Vol 2016 ◽  
pp. 1-4 ◽  
Author(s):  
Afsaneh Alikhassi ◽  
Fereshteh Ensani ◽  
Ramesh Omranipour ◽  
Alireza Abdollahi
Keyword(s):  
Rare Case ◽  
Pathological Examination ◽  
Breast Lesions ◽  
Clinical Correlation ◽  
Pseudoangiomatous Stromal Hyperplasia ◽  
Breast Enlargement ◽  
Histopathological Correlation ◽  
Mri Features ◽  
Tumoral Lesion ◽  
Bilateral Breast Enlargement

Pseudoangiomatous stromal hyperplasia (PASH) of the breast is a pathology that is usually diagnosed by accident during pathological examination of other breast lesions. PASH is an uncommon and benign tumoral lesion of the mammary stroma that can be pathologically mistaken for other tumours, such as phyllodes, fibroadenoma, and sometimes even angiosarcoma. We report the case of a 45-year-old woman with complaints of huge bilateral breast enlargement. This is a rare case of PASH presenting with gigantomastia and involving bilateral breasts and axillae simultaneously. Mammography, ultrasonography, and MRI features are illustrated with histopathological correlation.

Bilateral Reduction Mammoplasty after Heart Transplantation

2014 ◽  
Vol 17 (4) ◽  
pp. 224
Author(s):  
Yue-Dong Shi ◽  
Fa-Zhi Qi ◽  
Zi-Hao Feng
Keyword(s):  
Heart Transplantation ◽  
Reduction Mammoplasty ◽  
Vertical Scar ◽  
Normal Heart ◽  
Breast Enlargement ◽  
Breast Morphology ◽  
Systolic And Diastolic Function ◽  
Bilateral Breast Enlargement ◽  
Scar Reduction

We report a bilateral reduction mammoplasty in a 15 year old female who suffered increasing back and shoulder pain and chest wall discomfort associated with bilateral breast enlargement during a 17 month period following heart transplantation. Cardiologic evaluation confirmed a structurally normal heart with good systolic and diastolic function, and ejection fraction of 80%. We performed a bilateral mammoplasty using dermal suspension flap in vertical-scar reduction. The patient recovered satisfactorily without incident, and breast morphology was excellent at the 2 year 9 month follow-up, with no recurrence of her previous symptoms or further hyperplasia.

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