Efficacy of N-Acetylcysteine and Hydrated Sodium Calcium Aluminosilicate to Reduce the Effects of Aflatoxin B1 Intoxication in Broiler Chickens

2019 ◽  
Vol 61 (2) ◽  
pp. 18
Author(s):  
Khalil Attia ◽  
Mohamed Asser ◽  
F Tawfeek ◽  
Hanaa Basuney
Keyword(s):  
Aflatoxin B1 ◽  
Broiler Chickens ◽  
Sodium Calcium ◽  
Calcium Aluminosilicate

Dietary Strategies to Counteract the Effects of Mycotoxins: A Review

2001 ◽  
Vol 64 (1) ◽  
pp. 120-131 ◽  
Author(s):  
FABIO GALVANO ◽  
ANDREA PIVA ◽  
ALBERTO RITIENI ◽  
GIACOMO GALVANO
Keyword(s):  
Plant Extracts ◽  
Aflatoxin B1 ◽  
Activated Carbons ◽  
Antioxidant Properties ◽  
Medicinal Herbs ◽  
Sodium Calcium ◽  
Food Components ◽  
Ability To Act ◽  
Calcium Aluminosilicate ◽  
Dietary Strategies

We reviewed various dietary strategies to contain the toxic effects of mycotoxins using antioxidant compounds (selenium, vitamins, provitamins), food components (phenolic compounds, coumarin, chlorophyll and its derivatives, fructose, aspartame), medicinal herbs and plant extracts, and mineral and biological binding agents (hydrated sodium calcium aluminosilicate, bentonites, zeolites, activated carbons, bacteria, and yeast). Available data are primarily from in vitro studies and mainly focus on aflatoxin B1, whereas much less information is available about other mycotoxins. Compounds with antioxidant properties are potentially very efficacious because of their ability to act as superoxide anion scavengers. Interesting results have been obtained by food components contained in coffee, strawberries, tea, pepper, grapes, turmeric, Fava tonka, garlic, cabbage, and onions. Additionally, some medicinal herbs and plant extracts could potentially provide protection against aflatoxin B1 and fumonisin B1. Activated carbons, hydrated sodium calcium aluminosilicate, and bacteria seem to effectively act as binders. We conclude that dietary strategies are the most promising approach to the problem, considering their limited or nil interference in the food production process. Nevertheless, a great research effort is necessary to verify the in vivo detoxification ability of the purposed agents, their mode of action, possible long-term drawbacks of these detoxification-decontamination procedures, and their economical and technical feasibility.

scholarly journals Effects of a hydrated sodium calcium aluminosilicate (T-Bind) on mycotoxicosis in young broiler chickens

1998 ◽  
Vol 77 (10) ◽  
pp. 1502-1509 ◽  
Author(s):  
L.F. Kubena ◽  
R.B. Harvey ◽  
R.H. Bailey ◽  
S.A. Buckley ◽  
G.E. Rottinghaus
Keyword(s):  
Broiler Chickens ◽  
Sodium Calcium ◽  
Calcium Aluminosilicate

scholarly journals Efficient Aflatoxin B1 Sequestration by Yeast Cell Wall Extract and Hydrated Sodium Calcium Aluminosilicate Evaluated Using a Multimodal In-Vitro and Ex-Vivo Methodology

Toxins ◽  
2021 ◽  
Vol 13 (1) ◽  
pp. 24
Author(s):  
Alexandros Yiannikouris ◽  
Juha Apajalahti ◽  
Hannele Kettunen ◽  
Suvi Ojanperä ◽  
Andrew N. W. Bell ◽  
...  
Keyword(s):  
Cell Wall ◽  
Yeast Cell ◽  
Aflatoxin B1 ◽  
In Vitro Model ◽  
Ex Vivo ◽  
Intestinal Tissue ◽  
Sodium Calcium ◽  
Calcium Aluminosilicate ◽  
Vitro Model

In this work, adsorption of the carcinogenic mycotoxin aflatoxin B1 (AFB1) by two sequestrants—a yeast cell wall-based adsorbent (YCW) and a hydrated sodium calcium aluminosilicate (HSCAS)—was studied across four laboratory models: (1) an in vitro model from a reference method was employed to quantify the sorption capabilities of both sequestrants under buffer conditions at two pH values using liquid chromatography with fluorescence detection (LC-FLD); (2) in a second in vitro model, the influence of the upper gastrointestinal environment on the mycotoxin sorption capacity of the same two sequestrants was studied using a chronic AFB1 level commonly encountered in the field (10 µg/L and in the presence of feed); (3) the third model used a novel ex vivo approach to measure the absorption of 3H-labelled AFB1 in the intestinal tissue and the ability of the sequestrants to offset this process; and (4) a second previously developed ex vivo model readapted to AFB1 was used to measure the transfer of 3H-labelled AFB1 through live intestinal tissue, and the influence of sequestrants on its bioavailability by means of an Ussing chamber system. Despite some sorption effects caused by the feed itself studied in the second model, both in vitro models established that the adsorption capacity of both YCW and HSCAS is promoted at a low acidic pH. Ex vivo Models 3 and 4 showed that the same tested material formed a protective barrier on the epithelial mucosa and that they significantly reduced the transfer of AFB1 through live intestinal tissue. The results indicate that, by reducing the transmembrane transfer rate and reducing over 60% of the concentration of free AFB1, both products are able to significantly limit the bioavailability of AFB1. Moreover, there were limited differences between YCW and HSCAS in their sorption capacities. The inclusion of YCW in the dietary ration could have a positive influence in reducing AFB1′s physiological bioavailability.

The protective effect of hydrated sodium calcium aluminosilicate against the adverse effects of Aflatoxin B1 on D. melanogaster

2006 ◽  
Vol 22 (4) ◽  
pp. 173-179 ◽  
Author(s):  
Turgay Şişman
Keyword(s):  
Drosophila Melanogaster ◽  
Adverse Effects ◽  
Protective Effect ◽  
Aflatoxin B1 ◽  
Developmental Stages ◽  
Negative Effects ◽  
Sodium Calcium ◽  
Calcium Aluminosilicate ◽  
Aflatoxin B

The main aim of this study was to investigate the effects of Aflatoxin B1 (AFB1) and Aflatoxin B1-hydrated sodium calcium aluminosilicate (HSCAS) on various developmental stages of Drosophila melanogaster. Different concentrations of AFB1 and HSCAS-AFB1 were administered during the developmental periods of the fly (egg, larvae and pupae). When the F1 progeny of control and application groups were compared, AFB1 was found to extend the process of metamorphosis and decrease the total number of offspring. However, these negative effects were inhibited with HSCAS treatment at different concentrations (5.0 and 10.0 ppm). These results suggest that HSCAS could effectively inhibit AFB1-induced abnormalities in the developmental stages of D. melanogaster.

scholarly journals In vitro and in vivo efficacy of a hydrated sodium calcium aluminosilicate to bind and reduce aflatoxin residues in tissues of broiler chicks fed aflatoxin B1

2013 ◽  
Vol 92 (1) ◽  
pp. 131-137 ◽  
Author(s):  
D.V. Neeff ◽  
D.R. Ledoux ◽  
G.E. Rottinghaus ◽  
A.J. Bermudez ◽  
A. Dakovic ◽  
...  
Keyword(s):  
Aflatoxin B1 ◽  
Broiler Chicks ◽  
In Vivo Efficacy ◽  
Sodium Calcium ◽  
Calcium Aluminosilicate
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