A case report of lipoma-like hibernoma in axilla: A rarely benign tumor of brown adipose tissue

Ricardo Rubini Costa; Antonio Torregrosa Gallud; José Miguel Rayón; Jerónimo Forteza Vila

doi:10.5430/css.v4n1p1

A case report of lipoma-like hibernoma in axilla: A rarely benign tumor of brown adipose tissue

Case Studies in Surgery ◽

10.5430/css.v4n1p1 ◽

2018 ◽

Vol 4 (1) ◽

pp. 1

Author(s):

Ricardo Rubini Costa ◽

Antonio Torregrosa Gallud ◽

José Miguel Rayón ◽

Jerónimo Forteza Vila

Keyword(s):

Differential Diagnosis ◽

Benign Tumor ◽

Central Nucleus ◽

Resected Specimen ◽

Axial Tomography ◽

Brown Adipose ◽

Rare Benign Tumor ◽

Computerized Axial Tomography ◽

Histological Characteristics ◽

Well Differentiated

Background: Hibernoma or lipoma of brown fat is a rare benign tumor, representing 1.6% of the neoplasms of this tissue. Because of its histological characteristics can be wrongly classified as liposarcoma, therefore a correct differential diagnosis is necessary to provide appropriate treatment.Case presentation: The patient on which this case study is based is a 44-year-old male with a painless soft mass in his axilla located by his 4th and 5th ribs. The resected specimen did not have the classic macroscopic features of lipoma or fibrolipoma. Microscopically, the report described a proliferation of unilocular adipocytes with eccentric nucleus and, in less frequency, multilocular adipocytes with central nucleus. He had no recurrence after excision.Conclusions: Despite radiology studies and other technologies such as magnetic resonance imaging, computerized axial tomography (CAT), etc., the clinical diagnosis of hibernoma could be difficult. Lipoma-like hibernoma only have a few multilocular cells and can be wrongly classified as liposarcoma. Well-differentiated liposarcoma resembles it on low-power examination. Due to this it is especially important to perform a differential diagnosis with lipoma, fibroma, and even with liposarcoma. In this study we describe the histological features, the molecular markers and cytogenetic aspects that contribute to differentiate hibernoma from others tumors.

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Retroperitoneal Hibernoma: Exhibition of Three Case Reports and Literature Review

Surgical Case Reports ◽

10.31487/j.scr.2021.05.07 ◽

2021 ◽

pp. 1-5

Author(s):

Andrea Norte García ◽

Eulàlia Ballester Vázquez ◽

Lorena Cambeiro Cabré ◽

Mireia Solans Coll ◽

...

Keyword(s):

Differential Diagnosis ◽

Benign Tumor ◽

Case Reports ◽

The Body ◽

Extensive Review ◽

Definite Diagnosis ◽

Brown Adipose ◽

Rare Benign Tumor ◽

Well Differentiated ◽

Mesenchymal Tumours

Hibernoma is a rare benign tumor that becomes from the vestiges of fetal brown adipose tissue. It can be located on different regions of the body, being tight the most frequent. Retroperitoneal region is approximately of 9.4%. The first person to describe this histological type was Merkel. To the present, there are only described 25 cases on this location. It has a slowly growth, so it is normally asymptomatic, and it usually presents doing compression of different structures. To diagnose the MRI is the best prove, although biopsy will provide definite diagnosis describing four possible variants. Immunochemistry of MDM2, CDK4 and p16 genes is really important to do the differential diagnosis with well-differentiated liposarcoma (WDLS). Only one extensive review of hibernoma with 170 cases on different regions is published. But there is no review on literature specifically of retroperitoneal region, so this is the purpose of the current study. Following we present three more cases of retroperitoneal hibernoma that we have treat on our Mesenchymal Tumours Unit and a revision of the previously published.

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Laparoscopic Resection of a Giant Dedifferentiated Primary Retroperitoneal Mucinous Cystadenoma (PRMC) in a Young Woman: A Case Report and Literature Review

Journal of Clinical Case Studies ◽

10.16966/2471-4925.215 ◽

2021 ◽

Vol 6 (1) ◽

Author(s):

Wu L ◽

Li X ◽

Li J ◽

Lai Y

Keyword(s):

Differential Diagnosis ◽

Case Report ◽

Literature Review ◽

Benign Tumor ◽

Laparoscopic Resection ◽

Abdominal Cavity ◽

Mucinous Cystadenoma ◽

Rare Benign Tumor ◽

Primary Retroperitoneal

Background: PRMC is a very rare benign tumor of the abdominal cavity that usually occurs in women, and PRMC demonstrate no specific findings on CT. There are many reports on the differential diagnosis and discussion of PRMC imaging, but there are few reports on the treatment of dedifferentiated PRMC using laparoscopic resection and postoperative follow-up.

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First Report of a Lipoblastoma of the Parapharyngeal Space

Ear Nose & Throat Journal ◽

10.1177/014556130208100819 ◽

2002 ◽

Vol 81 (8) ◽

pp. 564-568 ◽

Cited By ~ 8

Author(s):

Kalpana DePasquale ◽

Daniel G. Deschler

Keyword(s):

Differential Diagnosis ◽

Head And Neck ◽

Benign Tumor ◽

Parapharyngeal Space ◽

First Report ◽

Parotid Region ◽

Rare Benign Tumor ◽

A Site

Lipoblastoma is a rare benign tumor that occurs primarily in children younger than 3 years of age. Fewer than 100 cases have been reported in the literature, and only eight cases have been previously reported in the head and neck; two of them occurred in the parotid region, where the differential diagnosis becomes quite extensive. We report a new case of head and neck lipoblastoma—one that occurred in the parapharyngeal space, a site that has not been previously reported. By doing so, we hope to promote awareness and consideration of lipoblastoma in the differential diagnosis of deep-parotid and para-pharyngeal-space neoplasms.

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Delineation of Chondroid Lipoma: An Immunohistochemical and Molecular Biological Analysis

Sarcoma ◽

10.1155/2011/638403 ◽

2011 ◽

Vol 2011 ◽

pp. 1-5 ◽

Cited By ~ 10

Author(s):

Ronald S. A. de Vreeze ◽

Frits van Coevorden ◽

Lucie Boerrigter ◽

Petra M. Nederlof ◽

Rick L. Haas ◽

...

Keyword(s):

Differential Diagnosis ◽

Benign Tumor ◽

Soft Tissue Tumors ◽

Fish Analysis ◽

Chondroid Lipoma ◽

Molecular Biological Analysis ◽

Morphological Aspects ◽

Myxoid Liposarcomas ◽

Well Differentiated ◽

Lipomatous Tumors

Aims. Chondroid lipoma (CL) is a benign tumor that mimics a variety of soft tissue tumors and is characterized by translocationt(11;16). Here, we analyze CL and its histological mimics.Methods. CL (n=4) was compared to a variety of histological mimics (n=83) for morphological aspects and immunohistochemical features including cyclinD1(CCND1). Using FISH analysis,CCND1andFUSwere investigated as potential translocation partners.Results. All CLs were strongly positive forCCND1. One of 4 myoepitheliomas,CCND1, was positive. In well-differentiated lipomatous tumors and in chondrosarcomas,CCND1was frequently expressed, but all myxoid liposarcomas were negative. FISH analysis did not give support for direct involvement ofCCND1andFUSas translocation partners.Conclusions. Chondroid lipoma is extremely rare and has several and more prevalent histological mimics. The differential diagnosis of chondroid lipomas can be unraveled using immunohistochemical and molecular support.

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Hibernoma of the axillary region: a rare benign adipocytic tumor

Rare Tumors ◽

10.4081/rt.2010.e7 ◽

2010 ◽

Vol 2 (1) ◽

pp. 20-22 ◽

Cited By ~ 2

Author(s):

Kanya Honoki ◽

Kouhei Morita ◽

Takahiko Kasai ◽

Hiromasa Fujii ◽

Akira Kido ◽

...

Keyword(s):

Malignant Neoplasm ◽

Brown Fat ◽

Fetal Life ◽

Mri Findings ◽

Brown Adipose ◽

Rare Benign Tumor ◽

Axillary Region ◽

Well Differentiated ◽

Slow Growing ◽

Interscapular Region

Hibernoma is a rare benign tumor considered to arise from remnants of fetal brown adipose tissue. It tends to occur in sites where brown fat persists beyond fetal life, such as the interscapular region, but can occur in sites where brown fat is usually absent in adults. Clinically, hibernomas are slow-growing, asymptomatic tumors. However, unlike lipomas, MRI findings sometimes mislead clinicians to diagnose a malignant neoplasm. We describe a 63-year-old male with an axillary hibernoma involving the brachial neurovascular bundles and mimicking a well-differentiated liposarcoma, from which it should be distinguished.

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Dentofacial Deformity Caused by Bulky Osteochondroma: Report of an Unusual Case and the Importance of Cone Beam Computed Tomography

The Open Dentistry Journal ◽

10.2174/1874210601711010237 ◽

2017 ◽

Vol 11 (1) ◽

pp. 237-241 ◽

Cited By ~ 2

Author(s):

Weeraya Tantanapornkul ◽

Kittipong Dhanuthai ◽

Phonkit Sinpitaksakul ◽

Chumpot Itthichaisri ◽

Paksinee Kamolratanakul ◽

...

Keyword(s):

Computed Tomography ◽

Differential Diagnosis ◽

Case Report ◽

Unusual Case ◽

Benign Tumor ◽

Mandibular Condyle ◽

Cone Beam ◽

Dentofacial Deformity ◽

Alternative Modality ◽

Rare Benign Tumor

Introduction: Osteochondroma of mandibular condyle is a rare benign tumor. Case Report: This case report described clinical, radiographic features, differential diagnosis, histopathologic correlation and treatment of condylar osteochondroma. Conclusion: Conebeam computed tomography (CBCT) is an alternative modality to CT or MRI that should be performed in all cases of suspected osteochondroma of the mandibular condyle.

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Orbital schwannoma with hyposmia as the only presentation: Case report and a literature review on differential diagnosis

Ear Nose & Throat Journal ◽

10.1177/01455613211059862 ◽

2021 ◽

pp. 014556132110598

Author(s):

Xiangyu Lou ◽

Bo Jiang ◽

Jianguang Zhong ◽

Jian Wu ◽

Haibin Wang ◽

...

Keyword(s):

Differential Diagnosis ◽

Preoperative Diagnosis ◽

Benign Tumor ◽

Mri Imaging ◽

Resonance Imaging ◽

Nerve Sheath ◽

Rare Benign Tumor ◽

Combined Imaging ◽

Magnetic Resonance Imaging Mri ◽

Atypical Presentations

Orbital schwannoma is a rare benign tumor, originating from the Schwann cells of the orbital peripheral nerve sheath. Orbital schwannoma is easily misdiagnosed if the patient shows atypical presentations and atypical appearance on MRI imaging. A 56-year-old male experienced hyposmia for 1 year and was misdiagnosed with cavernous hemangioma pre-operation. This case was treated by surgery through the endoscopic trans-nasal approach. After operation, the patient had no recurrence or complications. Preoperative diagnosis for these cases remains difficult. Combined imaging modalities including computed tomography (CT) and magnetic resonance imaging (MRI) can help in differential diagnosis. Surgery is the main treatment modality for treating orbital schwannoma. Outcomes in most cases are favorable without complications or recurrence.

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An Invasive Hemolymphangioma of the Pancreas in a Young Woman

Combinatorial Chemistry & High Throughput Screening ◽

10.2174/1386207322666190103110747 ◽

2019 ◽

Vol 21 (10) ◽

pp. 798-800 ◽

Cited By ~ 1

Author(s):

Zhijun Zhang ◽

Qinghong Ke ◽

Weiliang Xia ◽

Xiuming Zhang ◽

Yan Shen ◽

...

Keyword(s):

Computed Tomography ◽

Case Report ◽

Young Woman ◽

Benign Tumor ◽

Abdominal Distension ◽

Accurate Diagnosis ◽

Cystic Tumor ◽

Rare Benign Tumor ◽

Radical Surgical Resection

Background: Hemolymphangioma is a rare benign tumor. To the best of our knowledge, there were only 10 reports of this tumor of the pancreas until March 2018. Case Report: Here, we reported a large invasive hemolymphangioma of the pancreas in a young woman with a complaint of abdominal distension and an epigastric mass about 3 weeks. She was found to have a huge multilocular cystic tumor at the neck and body of pancreas on computed tomography. She was eventually diagnosed with hemolymphangioma of the pancreas after operation. After 2 years of follow-up, there was no signs of recurrence. Conclusion: From our case and literature, we can conclude that hemolymphangioma of the pancreas is uncommon benign tumor, and it is hard to make an accurate diagnosis preoperatively. Radical surgical resection should be performed whenever possible. The prognosis of this disease seems good.

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Testicular fibroma: A case report

Archive of oncology ◽

10.2298/aoo1304139s ◽

2013 ◽

Vol 21 (3-4) ◽

pp. 139-140

Author(s):

Sunita Shere ◽

Anjali Kulkarni ◽

Shubhjyoti Pore ◽

Rajan Bindu

Keyword(s):

Case Report ◽

Benign Tumor ◽

Histopathological Diagnosis ◽

Testicular Mass ◽

Rare Benign Tumor ◽

Testicular Malignancy ◽

Slow Growing

Testicular fibroma of gonadal stromal origin is a rare benign tumor of testis, which usually presents as a slow growing testicular mass. Intratesticular fibroma of gonadal stromal origin, with or without minor sex cord elements, must be considered, analogous to similar tumors in ovary, as a benign tumor. Until now, only 25 cases of testicular fibroma have been reported in the literature. We reported a case of testicular fibroma in a 20 years male who presented with painless right testicular enlargement since two years. Ultrasonography (USG) showed heterogeneous mass in right scrotum suggestive of testicular malignancy. Right orchidectomy was done. Histopathological diagnosis was testicular fibroma, which was confirmed by immunohistochemistry.

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