scholarly journals Brain tumor epidemiology in the era of precision medicine: The 2017 Brain Tumor Epidemiology Consortium meeting report

2017 ◽  
Vol 36 (11) ◽  
pp. 255-263 ◽  
Author(s):  
Kimberly J. Johnson ◽  
Judith Schwartzbaum ◽  
Carol Kruchko ◽  
Michael E. Scheurer ◽  
Ching C. Lau ◽  
...  
Keyword(s):  
Brain Tumor ◽  
Precision Medicine ◽  
Meeting Report

scholarly journals Brain Tumor Biobank Development for Precision Medicine: Role of the Neurosurgeon

2021 ◽  
Vol 11 ◽  
Author(s):  
Emilie Darrigues ◽  
Benjamin W. Elberson ◽  
Annick De Loose ◽  
Madison P. Lee ◽  
Ebonye Green ◽  
...  
Keyword(s):  
Brain Tumor ◽  
Next Generation Sequencing ◽  
Precision Medicine ◽  
Critical Role ◽  
First Year ◽  
Histopathological Diagnosis ◽  
Next Generation ◽  
Cancer Predisposition Syndrome ◽  
Generation Sequencing

Neuro-oncology biobanks are critical for the implementation of a precision medicine program. In this perspective, we review our first year experience of a brain tumor biobank with integrated next generation sequencing. From our experience, we describe the critical role of the neurosurgeon in diagnosis, research, and precision medicine efforts. In the first year of implementation of the biobank, 117 patients (Female: 62; Male: 55) had 125 brain tumor surgeries. 75% of patients had tumors biobanked, and 16% were of minority race/ethnicity. Tumors biobanked were as follows: diffuse gliomas (45%), brain metastases (29%), meningioma (21%), and other (5%). Among biobanked patients, 100% also had next generation sequencing. Eleven patients qualified for targeted therapy based on identification of actionable gene mutations. One patient with a hereditary cancer predisposition syndrome was also identified. An iterative quality improvement process was implemented to streamline the workflow between the operating room, pathology, and the research laboratory. Dedicated tumor bank personnel in the department of neurosurgery greatly improved standard operating procedure. Intraoperative selection and processing of tumor tissue by the neurosurgeon was integral to increasing success with cell culture assays. Currently, our institutional protocol integrates standard histopathological diagnosis, next generation sequencing, and functional assays on surgical specimens to develop precision medicine protocols for our patients. This perspective reviews the critical role of neurosurgeons in brain tumor biobank implementation and success as well as future directions for enhancing precision medicine efforts.

Brain tumor disparities: From biology to social determinants - The 2019 Brain Tumor Epidemiology Consortium meeting report

2019 ◽  
Vol 38 (11) ◽  
pp. 297-305
Author(s):  
Kimberly J. Johnson ◽  
Luc Bauchet ◽  
Johannes A. Hainfellner ◽  
Carol Kruchko ◽  
Michael E. Scheurer ◽  
...  
Keyword(s):  
Brain Tumor ◽  
Social Determinants ◽  
Meeting Report

scholarly journals A Preclinical Pipeline for Translational Precision Medicine—Experiences from a Transdisciplinary Brain Tumor Stem Cell Project

2021 ◽  
Vol 11 (9) ◽  
pp. 892
Author(s):  
Andres Vargas-Toscano ◽  
Christoph Janiak ◽  
Michael Sabel ◽  
Ulf Dietrich Kahlert
Keyword(s):  
Brain Tumor ◽  
Precision Medicine ◽  
Clinical Application ◽  
New Technologies ◽  
Basic Research ◽  
Therapy Resistance ◽  
Primary Brain Tumor ◽  
Point Of View ◽  
Tumor Stem Cell ◽  
Tumoral Cell

Efficient transdisciplinary cooperation promotes the rapid discovery and clinical application of new technologies, especially in the competitive sector of oncology. In this review, written from a clinical-scientist point of view, we used glioblastoma—the most common and most aggressive primary brain tumor as a model disease with a largely unmet clinical need, despite decades of intensive research—to promote transdisciplinary medicine. Glioblastoma stem-like cells (GSCs), a special tumoral cell population analogue to healthy stem cells, are considered largely responsible for the progression of the disease and the mediation of therapy resistance. The presented work followed the concept of translational science, which generates the theoretical backbones of translational research projects, and aimed to close the preclinical gap between basic research and clinical application. Thus, this generated an integrated translational precision medicine pipeline model based on recent theoretical and experimental publications, which supports the accelerated discovery and development of new paths in the treatment of GSCs. The work may be of interest to the general field of precision medicine beyond the field of neuro-oncology such as in Cancer Neuroscience.

scholarly journals EPT-20CLINICAL TARGETED EXOME-BASED SEQUENCING IN COMBINATION WITH GENOME WIDE COPY NUMBER PROFILING: A CLIA CERTIFIED APPROACH FOR PRECISION MEDICINE IN 203 PEDIATRIC BRAIN TUMOR PATIENTS

2016 ◽  
Vol 18 (suppl 3) ◽  
pp. iii28.2-iii28 ◽  
Author(s):  
Pratiti Bandopadhayay ◽  
Shakti Ramkissoon ◽  
Jaeho Hwang ◽  
Lori Ramkissoon ◽  
Adrian Dubuc ◽  
...  
Keyword(s):  
Brain Tumor ◽  
Precision Medicine ◽  
Copy Number ◽  
Pediatric Brain Tumor ◽  
Tumor Patients ◽  
Genome Wide ◽  
Pediatric Brain

scholarly journals Immune factors and viral interactions in brain cancer etiology and outcomes, The 2016 Brain Tumor Epidemiology Consortium Meeting report

2016 ◽  
Vol 35 (09) ◽  
pp. 280-286 ◽  
Author(s):  
Kimberly J. Johnson ◽  
Johannes A. Hainfellner ◽  
Ching C. Lau ◽  
Michael E. Scheurer ◽  
Adelheid Woehrer ◽  
...  
Keyword(s):  
Brain Tumor ◽  
Brain Cancer ◽  
Meeting Report ◽  
Cancer Etiology ◽  
Viral Interactions ◽  
Immune Factors

scholarly journals Advancing brain tumor epidemiology – multi-level integration and international collaboration: The 2018 Brain Tumor Epidemiology Consortium meeting report

2018 ◽  
Vol 37 (6) ◽  
pp. 254-261 ◽  
Author(s):  
Kimberly J. Johnson ◽  
Helle Broholm ◽  
Michael E. Scheurer ◽  
Ching C. Lau ◽  
Johannes A. Hainfellner ◽  
...  
Keyword(s):  
Brain Tumor ◽  
International Collaboration ◽  
Meeting Report ◽  
Multi Level

Brain tumor biomarkers for research, clinics, and registries - The 2021 Brain Tumor Epidemiology Consortium meeting report

2021 ◽  
Author(s):  
Kimberly J. Johnson ◽  
Judith Schwartzbaum ◽  
Carol Kruchko ◽  
Luc Bauchet ◽  
Quinn Ostrom ◽  
...  
Keyword(s):  
Brain Tumor ◽  
Meeting Report ◽  
Tumor Biomarkers

scholarly journals Clinical and research applications of a brain tumor tissue bank in the age of precision medicine

2019 ◽  
Vol 16 (2) ◽  
pp. 145-156 ◽  
Author(s):  
James Snyder ◽  
Laila M Poisson ◽  
Houtan Noushmehr ◽  
Ana V Castro ◽  
Ana C deCarvalho ◽  
...  
Keyword(s):  
Brain Tumor ◽  
Precision Medicine ◽  
Tumor Tissue ◽  
Tissue Bank

Meeting Report

2017 ◽  
Vol 7 (2) ◽  
pp. 116-119
Author(s):  
Thalia Merryweather ◽  
Zsófi Berkes
Keyword(s):  
Meeting Report
Sign in / Sign up

Export Citation Format

Share Document