Bioavailability study of two 81-mg coated tablet formulations of acetylsalicylic acid in fed healthy subjects

2020 ◽  
Vol 58 (08) ◽  
pp. 457-464
Author(s):  
Raul Cleverson Dolores ◽  
Natalícia de Jesus Antunes ◽  
Alexandre Scremin Czezacki ◽  
Carolina Previato ◽  
Rafael Campos ◽  
...  
Keyword(s):  
Acetylsalicylic Acid ◽  
Healthy Subjects ◽  
Coated Tablet ◽  
Bioavailability Study ◽  
Tablet Formulations

Comparative Bioavailability Study with Two Amiodarone Tablet Formulations Administered with and without Food in Healthy Subjects

2011 ◽  
Vol 57 (09) ◽  
pp. 582-590 ◽  
Author(s):  
Hilton Filho ◽  
Jaime Ilha ◽  
Lara Silva ◽  
André Borges ◽  
Gustavo Mendes ◽  
...  
Keyword(s):  
Healthy Subjects ◽  
Bioavailability Study ◽  
Comparative Bioavailability ◽  
Tablet Formulations ◽  
Comparative Bioavailability Study

Effects of nitroglycerin on platelet aggregation beyond the effects of acetylsalicylic acid in healthy subjects

1993 ◽  
Vol 71 (4) ◽  
pp. 361-364 ◽  
Author(s):  
Karl-Erik Karlberg ◽  
Johan Ahlner ◽  
Peter Henriksson ◽  
Kristina Torfgård ◽  
Christer Sylvén
Keyword(s):  
Platelet Aggregation ◽  
Acetylsalicylic Acid ◽  
Healthy Subjects

scholarly journals FORMULATION AND IN VITRO–IN VIVO PHARMACOKINETIC EVALUATION OF CARDIOVASCULAR DRUG-LOADED PULSATILE DRUG DELIVERY SYSTEMS

2021 ◽  
pp. 144-151
Author(s):  
KUMAR BABU PASUPULETI ◽  
VENKATACHALAM A. ◽  
BHASKAR REDDY KESAVAN
Keyword(s):  
Drug Release ◽  
Ethyl Cellulose ◽  
Release Kinetic ◽  
In Vitro Drug Release ◽  
The Core ◽  
Coated Tablet ◽  
Tablet Formulations ◽  
Core Tablet

Objective: This study is to formulate Nebivolol into a Pulsatile liquid, solid composite compression coated tablet, which will delay the release of the drug in early morning hypertension conditions. Methods: The liquid, solid composite tablet was formulated and compressed with the ethylcellulose coating polymer. The percent in vitro drug release of the liquid solid composite compressed tablet was tested. Based on disintegration time and wetting time, the LCS2, LCS3, LSC6, LCS7 and LCS12 formulations were found to be the optimized solid-liquid compacts fast-dissolving core tablet formulations, which may be excellent candidates for further coating with polymer to transfer into press coated pulsatile tablet formulations. Coating the core tablet with varying ethyl cellulose concentrations resulted in five different formulations of the pulsatile press-coated tablet (CT1, CT2, CT3, CT4, CT5). In vitro drug release, in vitro release, kinetic studies, in vivo pharmacokinetic and stability tests were all performed for the prepared pulsatile press coated tablet. Results: CT3 tablets are coated with ethyl cellulose polymer, which shows maximum controlled drug release from the core tablet i.e. 96.34±1.2% at 8th h. It shows there was an efficient delay in drug release form core tablet i.e. up to 3 h, followed by the maximum amount of drug release of 96.34±2.4 at 8h. Which shows the core drug will be more efficiently protected from the gastric acid environment 1.2 pH, duodenal environment 4.0 pH and release drug only in the small intestine. Conclusion: According to the findings, CT3 Pulsatile press-coated tablet increased the bioavailability of Nebivolol by 3.11 percent.

scholarly journals NOVEL APPROACH OF EXTRACTION AND CHARACTERIZATION OF OKRA GUM AS A BINDER FOR TABLET FORMULATION

2019 ◽  
Vol 12 (1) ◽  
pp. 189
Author(s):  
Shayeri Chatterjee ◽  
Rana Mazumder
Keyword(s):  
Hydroxypropyl Methylcellulose ◽  
Scanning Calorimetry ◽  
Swelling Properties ◽  
Novel Approach ◽  
Coated Tablet ◽  
Present Aspect ◽  
Tablet Formulations ◽  
Okra Gum ◽  
The Fourier Transform

Objective: The major objective of the present investigation was to extract a natural polymer (okra gum) with its characterization as pharmaceutical binder and to formulate, develop, and evaluate the compression-coated tablet using okra as binder along with synthetic hydrophilic polymers like various grades of hydroxypropyl methylcellulose (HPMC).Methods: A novel extraction method was carried out using fresh unripe pods of okra (ladies finger) with the aid of organic solvents and its characterization was done. The core tablets were prepared by direct compression method which was compression coated with okra gum and HPMC.Results: After the extraction of the okra gum was carried out, the yield of mucilage obtained was 10%. It is considered as a proof for the purity of the mucilage extract. The above study reveals that the polymers were subjected to the Fourier transform infrared and differential scanning calorimetry thermogram had no significant interactions between the drug and the polymers. The characterization of the new polymer okra showed that it has swelling properties, and in spite of being a hydrophilic polymer, it can be successfully used in pharmaceutical formulation as a good binder.Conclusion: In the present aspect of the study was to evaluate the efficacy of okra gum that has been used as a tablet binder. It is easily available and inexpensive. Okra gum as a binder produces tablet formulations with good physicochemical properties and good candidate for sustained release formulations.

Effect of acetylsalicylic acid intake on platelet derived microvesicles in healthy subjects

Platelets ◽  
2019 ◽  
Vol 31 (2) ◽  
pp. 206-214 ◽  
Author(s):  
Justyna Rosinska ◽  
Joanna Maciejewska ◽  
Robert Narożny ◽  
Krystyna Osztynowicz ◽  
Beata Raczak ◽  
...  
Keyword(s):  
Acetylsalicylic Acid ◽  
Healthy Subjects ◽  
Acid Intake
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