Evaluation of the pharmacokinetic interaction between ticagrelor and tolbutamide, a cytochrome P450 2C9 substrate, in healthy volunteers

Renli Teng; Patrick Mitchell; Kathleen Butler

doi:10.5414/cp201749

Evaluation of the pharmacokinetic interaction between ticagrelor and tolbutamide, a cytochrome P450 2C9 substrate, in healthy volunteers

International Journal of Clinical Pharmacology and Therapeutics ◽

10.5414/cp201749 ◽

2013 ◽

Vol 51 (04) ◽

pp. 305-312 ◽

Cited By ~ 4

Author(s):

Renli Teng ◽

Patrick Mitchell ◽

Kathleen Butler

Keyword(s):

Cytochrome P450 ◽

Healthy Volunteers ◽

Pharmacokinetic Interaction ◽

Cytochrome P450 2C9

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Non randomized study on the potential of nitisinone to inhibit cytochrome P450 2C9, 2D6, 2E1 and the organic anion transporters OAT1 and OAT3 in healthy volunteers

European Journal of Clinical Pharmacology ◽

10.1007/s00228-018-2581-7 ◽

2018 ◽

Vol 75 (3) ◽

pp. 313-320 ◽

Cited By ~ 3

Author(s):

Gunilla Huledal ◽

Birgitta Olsson ◽

Kristin Önnestam ◽

Per Dalén ◽

Daniel Lindqvist ◽

...

Keyword(s):

Cytochrome P450 ◽

Healthy Volunteers ◽

Organic Anion ◽

Randomized Study ◽

Organic Anion Transporters ◽

Cytochrome P450 2C9 ◽

Anion Transporters

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Involvement of cytochrome P450 2C9, 2E1 and 3A4 in trimethadione N-demethylation in human microsomes

Journal of Clinical Pharmacy and Therapeutics ◽

10.1046/j.1365-2710.2003.00524.x ◽

2003 ◽

Vol 28 (6) ◽

pp. 493-496 ◽

Cited By ~ 4

Author(s):

E. Tanaka ◽

N. Kurata ◽

H. Yasuhara

Keyword(s):

Cytochrome P450 ◽

Cytochrome P450 2C9

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A warfarin-dosing model in Asians that uses single-nucleotide polymorphisms in vitamin K epoxide reductase complex and cytochrome P450 2C9

Clinical Pharmacology & Therapeutics ◽

10.1016/j.clpt.2006.06.009 ◽

2006 ◽

Vol 80 (4) ◽

pp. 346-355 ◽

Cited By ~ 113

Author(s):

L THAM ◽

B GOH ◽

A NAFZIGER ◽

J GUO ◽

L WANG ◽

...

Keyword(s):

Cytochrome P450 ◽

Single Nucleotide Polymorphisms ◽

Vitamin K ◽

Nucleotide Polymorphisms ◽

Cytochrome P450 2C9 ◽

Single Nucleotide ◽

Vitamin K Epoxide Reductase ◽

Epoxide Reductase ◽

Warfarin Dosing

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No Pharmacokinetic Interaction Between Lacosamide and Carbamazepine in Healthy Volunteers

The Journal of Clinical Pharmacology ◽

10.1177/0091270009347675 ◽

2010 ◽

Vol 50 (4) ◽

pp. 459-471 ◽

Cited By ~ 55

Author(s):

Willi Cawello ◽

Brunhild Nickel ◽

Andrea Eggert-Formella

Keyword(s):

Healthy Volunteers ◽

Pharmacokinetic Interaction

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Drug Metabolism in Hemorrhagic Shock: Pharmacokinetics of Selective Markers of Cytochrome-P450 2C9, 2D6, and 3A4 Enzyme Activities in a Porcine Model

Journal of Surgical Research ◽

10.1016/j.jss.2010.06.040 ◽

2011 ◽

Vol 167 (2) ◽

pp. e231-e243 ◽

Cited By ~ 5

Author(s):

Atul Kumar ◽

Rory P. Remmel ◽

Henry J. Mann ◽

Greg J. Beilman

Keyword(s):

Cytochrome P450 ◽

Drug Metabolism ◽

Hemorrhagic Shock ◽

Enzyme Activities ◽

Porcine Model ◽

Cytochrome P450 2C9

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Cytochrome P450 2C9 gene polymorphism in phenytoin induced gingival enlargement: A case report

Journal of Pharmacy And Bioallied Sciences ◽

10.4103/0975-7406.116828 ◽

2013 ◽

Vol 5 (3) ◽

pp. 237 ◽

Cited By ~ 7

Author(s):

Agila Samidorai ◽

N. S. C. Charles ◽

S. P. K.Kennedy Babu ◽

V Ramesh

Keyword(s):

Cytochrome P450 ◽

Case Report ◽

Gene Polymorphism ◽

Cytochrome P450 2C9 ◽

Gingival Enlargement

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Rifampin enhances cytochrome P450 (CYP) 2B6-mediated efavirenz 8-hydroxylation in healthy volunteers

Drug Metabolism and Pharmacokinetics ◽

10.1016/j.dmpk.2015.07.002 ◽

2016 ◽

Vol 31 (2) ◽

pp. 107-116 ◽

Cited By ~ 6

Author(s):

Doo-Yeoun Cho ◽

Joan H.Q. Shen ◽

Suzanne M. Lemler ◽

Todd C. Skaar ◽

Lang Li ◽

...

Keyword(s):

Cytochrome P450 ◽

Healthy Volunteers

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Preparation, Characterization, and Substrate Metabolism of Gold-Immobilized Cytochrome P450 2C9

Journal of the American Chemical Society ◽

10.1021/ja0608693 ◽

2006 ◽

Vol 128 (26) ◽

pp. 8374-8375 ◽

Cited By ~ 16

Author(s):

Peter M. Gannett ◽

Jarod Kabulski ◽

Felio A. Perez ◽

Zhongyuan Liu ◽

David Lederman ◽

...

Keyword(s):

Cytochrome P450 ◽

Cytochrome P450 2C9 ◽

Substrate Metabolism

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Amino Acid Residues Affecting the Activities of Human Cytochrome P450 2C9 and 2C19

Drug Metabolism and Disposition ◽

10.1124/dmd.30.8.931 ◽

2002 ◽

Vol 30 (8) ◽

pp. 931-936 ◽

Cited By ~ 10

Author(s):

Toshiro Niwa ◽

Akira Kageyama ◽

Kae Kishimoto ◽

Yoshiyasu Yabusaki ◽

Fumihide Ishibashi ◽

...

Keyword(s):

Cytochrome P450 ◽

Amino Acid ◽

Amino Acid Residues ◽

Cytochrome P450 2C9 ◽

Human Cytochrome

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Interaction of drug metabolizing cytochrome P450 2D6 poor metabolizers with cytochrome P450 2C9 and 2C19 genotypes modify the susceptibility to head and neck cancer and treatment response

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis ◽

10.1016/j.mrfmmm.2009.11.010 ◽

2010 ◽

Vol 684 (1-2) ◽

pp. 49-55 ◽

Cited By ~ 14

Author(s):

Sunishtha S. Yadav ◽

Munindra Ruwali ◽

Mohan C. Pant ◽

Pragya Shukla ◽

Ram L. Singh ◽

...

Keyword(s):

Cytochrome P450 ◽

Head And Neck Cancer ◽

Head And Neck ◽

Treatment Response ◽

Neck Cancer ◽

Poor Metabolizers ◽

Cytochrome P450 2D6 ◽

Cytochrome P450 2C9 ◽

P450 2D6

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