Preparation, Characterization, and Substrate Metabolism of Gold-Immobilized Cytochrome P450 2C9

Peter M. Gannett; Jarod Kabulski; Felio A. Perez; Zhongyuan Liu; David Lederman; Charles W. Locuson; Robyn R. Ayscue; Nissa M. Thomsen; Timothy S. Tracy

doi:10.1021/ja0608693

Preparation, Characterization, and Substrate Metabolism of Gold-Immobilized Cytochrome P450 2C9

Journal of the American Chemical Society ◽

10.1021/ja0608693 ◽

2006 ◽

Vol 128 (26) ◽

pp. 8374-8375 ◽

Cited By ~ 16

Author(s):

Peter M. Gannett ◽

Jarod Kabulski ◽

Felio A. Perez ◽

Zhongyuan Liu ◽

David Lederman ◽

...

Keyword(s):

Cytochrome P450 ◽

Cytochrome P450 2C9 ◽

Substrate Metabolism

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Involvement of cytochrome P450 2C9, 2E1 and 3A4 in trimethadione N-demethylation in human microsomes

Journal of Clinical Pharmacy and Therapeutics ◽

10.1046/j.1365-2710.2003.00524.x ◽

2003 ◽

Vol 28 (6) ◽

pp. 493-496 ◽

Cited By ~ 4

Author(s):

E. Tanaka ◽

N. Kurata ◽

H. Yasuhara

Keyword(s):

Cytochrome P450 ◽

Cytochrome P450 2C9

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A warfarin-dosing model in Asians that uses single-nucleotide polymorphisms in vitamin K epoxide reductase complex and cytochrome P450 2C9

Clinical Pharmacology & Therapeutics ◽

10.1016/j.clpt.2006.06.009 ◽

2006 ◽

Vol 80 (4) ◽

pp. 346-355 ◽

Cited By ~ 113

Author(s):

L THAM ◽

B GOH ◽

A NAFZIGER ◽

J GUO ◽

L WANG ◽

...

Keyword(s):

Cytochrome P450 ◽

Single Nucleotide Polymorphisms ◽

Vitamin K ◽

Nucleotide Polymorphisms ◽

Cytochrome P450 2C9 ◽

Single Nucleotide ◽

Vitamin K Epoxide Reductase ◽

Epoxide Reductase ◽

Warfarin Dosing

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Investigation of the role of cytochrome P450 2B4 active site residues in substrate metabolism based on crystal structures of the ligand-bound enzyme

Archives of Biochemistry and Biophysics ◽

10.1016/j.abb.2006.08.024 ◽

2006 ◽

Vol 455 (1) ◽

pp. 61-67 ◽

Cited By ~ 16

Author(s):

Cynthia E. Hernandez ◽

Santosh Kumar ◽

Hong Liu ◽

James R. Halpert

Keyword(s):

Cytochrome P450 ◽

Crystal Structures ◽

Active Site ◽

Active Site Residues ◽

Substrate Metabolism ◽

Cytochrome P450 2B4

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Drug Metabolism in Hemorrhagic Shock: Pharmacokinetics of Selective Markers of Cytochrome-P450 2C9, 2D6, and 3A4 Enzyme Activities in a Porcine Model

Journal of Surgical Research ◽

10.1016/j.jss.2010.06.040 ◽

2011 ◽

Vol 167 (2) ◽

pp. e231-e243 ◽

Cited By ~ 5

Author(s):

Atul Kumar ◽

Rory P. Remmel ◽

Henry J. Mann ◽

Greg J. Beilman

Keyword(s):

Cytochrome P450 ◽

Drug Metabolism ◽

Hemorrhagic Shock ◽

Enzyme Activities ◽

Porcine Model ◽

Cytochrome P450 2C9

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Cytochrome P450 2C9 gene polymorphism in phenytoin induced gingival enlargement: A case report

Journal of Pharmacy And Bioallied Sciences ◽

10.4103/0975-7406.116828 ◽

2013 ◽

Vol 5 (3) ◽

pp. 237 ◽

Cited By ~ 7

Author(s):

Agila Samidorai ◽

N. S. C. Charles ◽

S. P. K.Kennedy Babu ◽

V Ramesh

Keyword(s):

Cytochrome P450 ◽

Case Report ◽

Gene Polymorphism ◽

Cytochrome P450 2C9 ◽

Gingival Enlargement

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Amino Acid Residues Affecting the Activities of Human Cytochrome P450 2C9 and 2C19

Drug Metabolism and Disposition ◽

10.1124/dmd.30.8.931 ◽

2002 ◽

Vol 30 (8) ◽

pp. 931-936 ◽

Cited By ~ 10

Author(s):

Toshiro Niwa ◽

Akira Kageyama ◽

Kae Kishimoto ◽

Yoshiyasu Yabusaki ◽

Fumihide Ishibashi ◽

...

Keyword(s):

Cytochrome P450 ◽

Amino Acid ◽

Amino Acid Residues ◽

Cytochrome P450 2C9 ◽

Human Cytochrome

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Interaction of drug metabolizing cytochrome P450 2D6 poor metabolizers with cytochrome P450 2C9 and 2C19 genotypes modify the susceptibility to head and neck cancer and treatment response

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis ◽

10.1016/j.mrfmmm.2009.11.010 ◽

2010 ◽

Vol 684 (1-2) ◽

pp. 49-55 ◽

Cited By ~ 14

Author(s):

Sunishtha S. Yadav ◽

Munindra Ruwali ◽

Mohan C. Pant ◽

Pragya Shukla ◽

Ram L. Singh ◽

...

Keyword(s):

Cytochrome P450 ◽

Head And Neck Cancer ◽

Head And Neck ◽

Treatment Response ◽

Neck Cancer ◽

Poor Metabolizers ◽

Cytochrome P450 2D6 ◽

Cytochrome P450 2C9 ◽

P450 2D6

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Comparison of Cytochrome P450 2C9 Genotyping Methods and Implications for the Clinical Laboratory

Yearbook of Pathology and Laboratory Medicine ◽

10.1016/s1077-9108(08)70244-5 ◽

2006 ◽

Vol 2006 ◽

pp. 323-324

Author(s):

M.G. Bissell

Keyword(s):

Cytochrome P450 ◽

Clinical Laboratory ◽

Cytochrome P450 2C9

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Cytochrome P450 2C9 polymorphism: Effect of amino acid substitutions on protein flexibility in the presence of tamoxifen

Computational Biology and Chemistry ◽

10.1016/j.compbiolchem.2019.107166 ◽

2020 ◽

Vol 84 ◽

pp. 107166 ◽

Cited By ~ 2

Author(s):

Manish Manish ◽

Andrew M Lynn ◽

Smriti Mishra

Keyword(s):

Cytochrome P450 ◽

Amino Acid ◽

Protein Flexibility ◽

Amino Acid Substitutions ◽

Cytochrome P450 2C9

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An amperometric biosensor based on human cytochrome P450 2C9 in polyacrylamide hydrogel films for bisphenol A determination

Sensors and Actuators B Chemical ◽

10.1016/j.snb.2012.12.055 ◽

2013 ◽

Vol 178 ◽

pp. 113-118 ◽

Cited By ~ 30

Author(s):

Pengyu Sun ◽

Yunhua Wu

Keyword(s):

Cytochrome P450 ◽

Bisphenol A ◽

Amperometric Biosensor ◽

Polyacrylamide Hydrogel ◽

Cytochrome P450 2C9 ◽

Human Cytochrome ◽

Hydrogel Films

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