Gene polymorphism in the promoter region of lipopolysaccharide receptor CD14 and dyslipidemia in hemodialysis patients

2003 ◽  
Vol 60 (09) ◽  
pp. 220-221
Author(s):  
M. Fukui ◽  
I. Shou ◽  
T. Gohda ◽  
C. Hamada ◽  
K. Maeda ◽  
...  
Keyword(s):  
Gene Polymorphism ◽  
Promoter Region ◽  
Hemodialysis Patients ◽  
Lipopolysaccharide Receptor

Relative risk for cardiovascular morbidity in hemodialysis patients regarding gene polymorphism for IL-10, IL-6, and TNF

2016 ◽  
Vol 94 (10) ◽  
pp. 1106-1109 ◽  
Author(s):  
J. Tosic Dragovic ◽  
J. Popovic ◽  
P. Djuric ◽  
A. Jankovic ◽  
A. Bulatovic ◽  
...  
Keyword(s):  
Gene Polymorphism ◽  
Cerebrovascular Accident ◽  
Gene Polymorphisms ◽  
Cardiovascular Events ◽  
Medical Center ◽  
Hemodialysis Patients ◽  
Left Ventricular ◽  
Cardiovascular Morbidity ◽  
Number Of Patients ◽  
Tnf Gene

Uremia-related inflammation is prone to be a key factor to explain high cardiovascular morbidity in hemodialysis patients. Genetic susceptibility may be of importance, including IL-10, IL-6, and TNF. The aim was to analyze IL-10, IL-6, and TNF gene polymorphisms in a group of hemodialysis patients and to correlate the findings with cardiovascular morbidity. This study included 169 patients on regular hemodialysis at Zvezdara University Medical Center. Gene polymorphisms for IL-10, IL-6 and TNF were determined using PCR. These findings were correlated with the cardiovascular morbidity data from patient histories. Heterozygots for IL-10 gene showed significantly lower incidence of cardiovascular events (p = 0.05) and twice lower risk for development of myocardial infarction, but experienced twice higher risk for left ventricular hypertrophy. Regarding TNF gene polymorphism, patients with A allele had 1.5-fold higher risk for cerebrovascular accident and cardiovascular events and 2-fold higher risk for hypertension and peripheral vascular disease. Patients with G allele of IL-6 gene experienced 1.5-fold higher risks for cerebrovascular accident. We need studies with larger number of patients for definitive conclusion about the influence of gene polymorphisms on cardiovascular morbidity in hemodialysis patients and its importance in everyday clinical practice.

scholarly journals SP592INFLUENCE OF CYTOKINE GENE POLYMORPHISM ON VASCULAR ACCESS THROMBOSIS IN CHRONIC HEMODIALYSIS PATIENTS

2015 ◽  
Vol 30 (suppl_3) ◽  
pp. iii574-iii574
Author(s):  
Aleksandar Jankovic ◽  
Marko Barovic ◽  
Jelena Tosic-Dragovic ◽  
Petar Djuric ◽  
Ana Bulatovic ◽  
...  
Keyword(s):  
Gene Polymorphism ◽  
Vascular Access ◽  
Hemodialysis Patients ◽  
Chronic Hemodialysis ◽  
Cytokine Gene ◽  
Cytokine Gene Polymorphism

scholarly journals ACE gene polymorphism and its association with serum erythropoietin and hemoglobin ‎in Iraqi hemodialysis patients

2019 ◽  
Vol Volume 12 ◽  
pp. 107-112
Author(s):  
Mohanad Yasir Al-Radeef ‎ ◽  
Hayder Adnan Fawzi ◽  
Ali Abdulmajid Allawi
Keyword(s):  
Gene Polymorphism ◽  
Hemodialysis Patients ◽  
Em Gene ◽  
Serum Erythropoietin

−295 T-to-C promoter region IL-16 gene polymorphism is associated with Whipple’s disease

2015 ◽  
Vol 34 (9) ◽  
pp. 1919-1921 ◽  
Author(s):  
F. Biagi ◽  
A. Schiepatti ◽  
C. Badulli ◽  
I. Sbarsi ◽  
L. Trotta ◽  
...  
Keyword(s):  
Gene Polymorphism ◽  
Promoter Region ◽  
Whipple’S Disease ◽  
Whipple's Disease
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