scholarly journals Oral Administration of the Probiotic Lactobacillus casei Ameliorates Gut Morphology and Physiology in Malnourished-Giardia intestinalis-Infected BALB/c Mice

2013 ◽  
Vol 2013 ◽  
pp. 1-8 ◽  
Author(s):  
Geeta Shukla ◽  
Sumedha Singh ◽  
Angela Verma
Keyword(s):  
Small Intestine ◽  
Oral Administration ◽  
Lactobacillus Casei ◽  
Brush Border Membrane ◽  
Mucosal Damage ◽  
Host Immunity ◽  
Giardia Intestinalis ◽  
Host Susceptibility ◽  
Gut Morphology ◽  
Membrane Enzyme

Malnutrition reduces the host immunity and enhances the host susceptibility to various diseases. The present study describes the effect of oral administration of probiotic Lactobacillus casei to malnourished-Giardia-infected BALB/c mice with respect to surface alterations and brush border membrane enzyme activity of the small intestine. It was observed that probiotic feeding either prior to or simultaneously with Giardia infection to malnourished mice led to significantly enhanced activity of disaccharidases compared with malnourished and Giardia-infected mice. Scanning electron microscopy also revealed less mucosal damage in the villi of small intestine of probiotic-fed malnourished-Giardia-infected mice compared with completely damaged, mummified, or blunted villi of malnourished-Giardia-infected mice. The findings indicate that probiotics can be used as the prophylactic candidate in abrogating the gut and intestinal dissacharidases anamolies in malnourished hosts suffering from the intestinal diseases.

Hydrolysis and transglycosylation activities of glycosidases from small intestine brush-border membrane vesicles

2021 ◽  
Vol 139 ◽  
pp. 109940
Author(s):  
Lesbia Cristina Julio-Gonzalez ◽  
F. Javier Moreno ◽  
María Luisa Jimeno ◽  
Elisa G. Doyagüez ◽  
Agustín Olano ◽  
...  
Keyword(s):  
Small Intestine ◽  
Brush Border ◽  
Brush Border Membrane ◽  
Membrane Vesicles ◽  
Brush Border Membrane Vesicles

Magnetically actuated intelligent hydrogel-based child-parent microrobots for targeted drug delivery

2021 ◽  
Author(s):  
Weinan Chen ◽  
Yongbing Wen ◽  
Xinjian Fan ◽  
Mengmeng Sun ◽  
Chenyao Tian ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Small Intestine ◽  
Oral Administration ◽  
Targeted Drug Delivery ◽  
Magnetically Actuated ◽  
Targeted Drug ◽  
Intelligent Hydrogel

Small intestine-targeted drug delivery by oral administration has aroused the growing interest of researchers.

IMMUNOLOGICAL ASPECT OF ORAL ADMINISTRATION OF THE PROBIOTIC LACTOBACILLUS CASEI LB 148 UNDER COLD STRESS IN ANIMALS

2020 ◽  
Author(s):  
G.V. Kozlovskaya ◽  
◽  
M.I. Zinevich ◽  
Y.E. Kozlovsky ◽  
T.I. Khomyakova ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Oral Administration ◽  
Cold Stress ◽  
Gut Microbiome ◽  
Lactobacillus Casei ◽  
Causative Factor ◽  
Sprague Dawley ◽  
Immunological Aspect ◽  
Intestinal Lymph ◽  
Probiotic Lactobacillus

Gut microbiome changes is considered as a basic causative factor of stress-associated diseases. Probiotics are usually used for the correction of disbiosis. The aim of the investigation was the study of the effects of oral probiotic Lactobacillus casei LB 148 use onto the gut microbiota as well as the number and total square of intestinal lymph nodules of rats Sprague Dawley at in health rats and under the cold stress

Effect of Lactobacillus casei and Yogurt Administration on Prevention of Pseudomonas aeruginosa Infection in Young Mice

2001 ◽  
Vol 64 (11) ◽  
pp. 1768-1774 ◽  
Author(s):  
SUSANA ALVAREZ ◽  
CLAUDIA HERRERO ◽  
ELENA BRU ◽  
GABRIELA PERDIGON
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Oral Administration ◽  
Lactobacillus Casei ◽  
Opportunistic Pathogen ◽  
Lung Infection ◽  
Pseudomonas Aeruginosa Infection ◽  
Dose Dependent ◽  
Chronic Pneumonia ◽  
Dose Dependent Effect ◽  
Young Mice

Pseudomonas aeruginosa is an opportunistic pathogen that rarely causes pulmonary disease in normal hosts but one that is an important cause of acute pneumonia in immunocompromised patients, including neonates, and of chronic pneumonia in patients with cystic fibrosis. The aim of this work was to study the effect of oral administration of Lactobacillus casei and yogurt on prevention of P. aeruginosa lung infection in young mice (3 weeks old). This study demonstrates that oral administration of L. casei or yogurt to young mice enhanced lung clearance of P. aeruginosa and phagocytic activity of alveolar macrophages through a dose-dependent effect. There were, however, no significant differences in white blood cell (WBC) differential counts. Furthermore, it was observed that previous administration of L. casei or yogurt induced a significant increase in IgA and IgM levels in bronchoalveolar lavages (BALs) after a P. aeruginosa infection, although there was no relationship with the serum values.

scholarly journals Augmentation of Cellular Immunity and Reduction of Influenza Virus Titer in Aged Mice Fed Lactobacillus casei Strain Shirota

2002 ◽  
Vol 9 (1) ◽  
pp. 105-108 ◽  
Author(s):  
Tetsuji Hori ◽  
Junko Kiyoshima ◽  
Kan Shida ◽  
Hisako Yasui
Keyword(s):  
Influenza Virus ◽  
Oral Administration ◽  
Cellular Immunity ◽  
Lactobacillus Casei ◽  
Control Diet ◽  
Killer Activity ◽  
Aged Mice ◽  
Tnf Α ◽  
Ifn Γ ◽  
Upper Respiratory

ABSTRACT We investigated whether oral administration of Lactobacillus casei strain Shirota activates the cellular immune system and ameliorates influenza virus (IFV) titer in the nasal site in upper respiratory IFV infection by using aged mice. Natural killer activity of splenocytes and lung cells of aged mice fed an L. casei strain Shirota diet (L.casei strain Shirota group) was significantly (P < 0.01 and P < 0.05) increased compared to those fed a control diet (control group). The increases were 1.5- and 2.5-fold, respectively. In aged mice fed an XL.casei strain Shirota diet, potent induction of gamma interferon (IFN-γ) and tumor necrosis factor alpha (TNF-α), which play a very important role in excluding IFV, was evident in nasal lymphocytes. IFN-γ and TNF-α production increased 12- and 3.5-fold, respectively. In this model of upper respiratory IFV infection, the titer of IFV in the nasal washings of aged mice fed an L.casei strain Shirota diet was significantly (P < 0.05) lower than that in aged mice fed a control diet (101.6 ± 0.6 and 102.2 ± 0.5, respectively). These findings suggest that oral administration of L.casei strain Shirota activates not only systemic cellular immunity but also local cellular immunity and that it ameliorates IFV infection.

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