scholarly journals Effect of Acute Mental Stress on Heart Rate and QT Variability in Postmyocardial Infarction Patients

2012 ◽  
Vol 2012 ◽  
pp. 1-9 ◽  
Author(s):  
Damiano Magrì ◽  
Gianfranco Piccirillo ◽  
Raffaele Quaglione ◽  
Annalaura Dell’Armi ◽  
Marilena Mitra ◽  
...  
Keyword(s):  
Acute Stress ◽  
Management Strategies ◽  
Low Frequency ◽  
Frequency Component ◽  
Postmyocardial Infarction ◽  
Increased Risk ◽  
Qt Variability Index ◽  
Qt Variability ◽  
Variability Index

Emotionally charged events are associated with an increased risk of sudden cardiac death (SCD). In this study we assessed RR and QT variability index (QTVI) at baseline during anger recall test (AR). We calculated QTVI from a 5-min ECG recording and from a 10-beats segment around the presumed maximum sympathetic activation in thirty post-myocardial infarction patients under β-blocker therapy and 10 controls underwent. In all groups, the low-frequency component of RR and SBP increased during AR. In all recordings, the QTVI calculated on a 5-min ECG recording and the were higher in patients than in controls (P < 0.05). The QTVI during AR remained unchanged from baseline within each group. Conversely, during AR, the in controls diminished significantly (P < 0.05) from baseline whereas in patients remained unchanged. The inability to buffer an acute stress-induced increase in sympathetic activity could explain why events charged with acute stress are associated with an increased risk of ventricular arrhythmias in this setting of patients and support the role of cognitive behavior stress management strategies.

Elevated temporal QT variability index in patients with chronic renal failure

2004 ◽  
Vol 107 (6) ◽  
pp. 583-588 ◽  
Author(s):  
Mats JOHANSSON ◽  
Sinsia A. GAO ◽  
Peter FRIBERG ◽  
Marita ANNERSTEDT ◽  
Göran BERGSTRÖM ◽  
...  
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Conservative Treatment ◽  
Sudden Death ◽  
Ventricular Arrhythmia ◽  
Healthy Subjects ◽  
Increased Risk ◽  
Qt Variability Index ◽  
Qt Variability ◽  
Variability Index

Patients with CRF (chronic renal failure) are at increased risk of cardiovascular diseases, and 60% of cardiovascular mortality in CRF is attributed to sudden death. Various abnormalities in myocardial repolarization are associated with the risk of ventricular arrhythmia. The aim of this study was to evaluate an index of temporal myocardial repolarization lability, the temporal QTVI (QT variability index), in patients with CRF. ECGs were recorded in 153 patients with CRF on haemodialysis (n=67), continuous ambulatory peritoneal dialysis (n=43) or conservative treatment (n=43) during 30 min of rest. QTVI was calculated as the logarithm of the ratio between the variances of the normalized QT and RR intervals. Age-matched healthy subjects (n=39) were examined for comparison. QTVI was increased by 47% in CRF patients compared with healthy subjects (−0.82±0.56 compared with −1.54±0.27 respectively; P<0.01). QTVI did not differ among patients on dialysis or conservative treatment, whereas QTVI was elevated further in patients with diabetes compared with non-diabetic CRF patients (−0.56±0.54 compared with −0.94±0.52 respectively; P<0.01). In a multiple linear regression analysis, diabetes and a history of coronary artery disease were the only independent predictors of QTVI in the CRF population. The present study demonstrates that elevated QTVI in patients with CRF is associated with diabetes and coronary disease. The present findings are important given that repolarization instability may predispose to ventricular arrhythmia and sudden death, events that occur frequently in CRF patients.

scholarly journals Influence of the 2015–2016 El Niño on the record-breaking mangrove dieback along northern Australia coast

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
S. Abhik ◽  
Pandora Hope ◽  
Harry H. Hendon ◽  
Lindsay B. Hutley ◽  
Stephanie Johnson ◽  
...  
Keyword(s):  
El Niño ◽  
El Nino ◽  
Southern Oscillation ◽  
Low Frequency ◽  
Multiple Linear Regression Model ◽  
Frequency Component ◽  
Enso Cycle ◽  
Northern Australia ◽  
Climate Conditions

AbstractThis study investigates the underlying climate processes behind the largest recorded mangrove dieback event along the Gulf of Carpentaria coast in northern Australia in late 2015. Using satellite-derived fractional canopy cover (FCC), variation of the mangrove canopies during recent decades are studied, including a severe dieback during 2015–2016. The relationship between mangrove FCC and climate conditions is examined with a focus on the possible role of the 2015–2016 El Niño in altering favorable conditions sustaining the mangroves. The mangrove FCC is shown to be coherent with the low-frequency component of sea level height (SLH) variation related to the El Niño Southern Oscillation (ENSO) cycle in the equatorial Pacific. The SLH drop associated with the 2015–2016 El Niño is identified to be the crucial factor leading to the dieback event. A stronger SLH drop occurred during austral autumn and winter, when the SLH anomalies were about 12% stronger than the previous very strong El Niño events. The persistent SLH drop occurred in the dry season of the year when SLH was seasonally at its lowest, so potentially exposed the mangroves to unprecedented hostile conditions. The influence of other key climate factors is also discussed, and a multiple linear regression model is developed to understand the combined role of the important climate variables on the mangrove FCC variation.

scholarly journals Maturation of the QT Variability Index is Impaired in Preterm Infants

2018 ◽  
Vol 39 (5) ◽  
pp. 902-905 ◽  
Author(s):  
Arisa Kojima ◽  
Tadayoshi Hata ◽  
Tsuneaki Sadanaga ◽  
Yuri Mizutani ◽  
Hidetoshi Uchida ◽  
...  
Keyword(s):  
Preterm Infants ◽  
Qt Variability Index ◽  
Qt Variability ◽  
Variability Index

Abstract P219: Mice Exposed To Early Life Stress Have Impaired Autonomic Activity At Baseline And In Response To Acute Stress In Adulthood

Hypertension ◽  
2020 ◽  
Vol 76 (Suppl_1) ◽  
Author(s):  
Megan K Rhoads ◽  
Kasi C McPherson ◽  
Keri M Kemp ◽  
Bryan Becker ◽  
Jackson Colson ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Life Stress ◽  
Early Life ◽  
Maternal Separation ◽  
Acute Stress ◽  
Low Frequency ◽  
Early Life Stress ◽  
Total Power ◽  
Increased Risk ◽  
Inactive Period

Early life stress (ELS) is an independent risk factor for the development of cardiovascular disease in adulthood in both humans and rodent models. Maternal separation and early weaning (MSEW), a model of ELS, produces mice with an increased risk of cardiovascular dysfunction in adulthood, despite resting blood pressures (BP), heart rates (HR), and body weights comparable to normally reared controls. Autonomic regulation of HR and BP is an important component of the homeostatic response to stress but has not been investigated in MSEW mice. We hypothesized that exposure to MSEW impairs autonomic function at baseline and in response to an acute psychosocial stressor in adult male mice. C57Bl/6J litters were randomly assigned to MSEW or normally reared control conditions. MSEW litters were separated from dams for 4 h on postnatal days (PDs) 2-5, 8 h on PDs 6-16, and weaned at PD 17. Control litters were undisturbed until weaning at PD 21. At 9 weeks old, telemeters were implanted in MSEW (n=16) and control mice (n=12). During cage switch stress (CSS), mice were moved to a soiled, unfamiliar cage for 4 h. HR, systolic BP (SBP), diastolic BP (DBP), and activity (monitored by telemetry) were similar between control and MSEW mice at baseline and during CSS (p>0.05, 2-way ANOVA). Spectral analysis of HR, SBP, and DBP indicated that HR variability (HRV) total power was lower in MSEW mice during the 12 h inactive period compared to controls (18.9±1.1 ms 2 vs. 27.5±3.1 ms 2 ; p=0.0033, 2-way ANOVA) at baseline. HRV low frequency (LF) power was also lower during the 12 h inactive period in MSEW mice (4.2±0.4 ms 2 vs.6.6±0.9 ms 2 ; p=0.009). At baseline, 12 h and 24 h DBP variability LF/high frequency (HF) ratio, normalized LF, and normalized HF power were lower in the MSEW group (p<0.05, all comparisons). During the final 90 minutes of CSS, MSEW mice had lower HRV total, LF, and HF power compared to controls (p<0.05); although HR, SBP, DBP, and activity remained similar between groups. These data suggest that MSEW mice have impaired autonomic control of HR and DBP and lack the ability to robustly respond and recover from an acute stressor. Reduced responsiveness of the autonomic nervous system may contribute to the increased risk of cardiovascular disease development in adult mice exposed to MSEW.

Increased QT variability index as a marker for a cardiac autonomic dysregulation in schizophrenia

2013 ◽  
Author(s):  
Hariton Costin ◽  
Steffen Schulz ◽  
Karl-Jurgen Bar ◽  
Ioana Alexa ◽  
Felix Adochiei ◽  
...  
Keyword(s):  
Autonomic Dysregulation ◽  
Qt Variability Index ◽  
Qt Variability ◽  
Variability Index

The QT Variability Index: A Multidimensional Approach to Understanding Cardiovascular Disease

Cardiology ◽  
2011 ◽  
Vol 118 (1) ◽  
pp. 42-44 ◽  
Author(s):  
Gianfranco Piccirillo ◽  
Pietro Rossi ◽  
Damiano Magrì
Keyword(s):  
Cardiovascular Disease ◽  
Multidimensional Approach ◽  
Qt Variability Index ◽  
Qt Variability ◽  
Variability Index

scholarly journals Transcranial direct current stimulation improves the QT variability index and autonomic cardiac control in healthy subjects older than 60 years

2016 ◽  
Vol Volume 11 ◽  
pp. 1687-1695 ◽  
Author(s):  
Gianfranco Piccirillo ◽  
Cristina Ottaviani ◽  
Claudia Fiorucci ◽  
Nicola Petrocchi ◽  
Federica Moscucci ◽  
...  
Keyword(s):  
Direct Current ◽  
Transcranial Direct Current Stimulation ◽  
Healthy Subjects ◽  
Direct Current Stimulation ◽  
Cardiac Control ◽  
Qt Variability Index ◽  
Qt Variability ◽  
Variability Index

Cerebral amyloid angiopathy–associated intracerebral hemorrhage: pathology and management

2012 ◽  
Vol 32 (4) ◽  
pp. E7 ◽  
Author(s):  
Prachi Mehndiratta ◽  
Sunil Manjila ◽  
Thomas Ostergard ◽  
Sylvia Eisele ◽  
Mark L. Cohen ◽  
...  
Keyword(s):  
Intracerebral Hemorrhage ◽  
Cerebral Amyloid Angiopathy ◽  
Management Strategies ◽  
Case Series ◽  
The Elderly ◽  
Postoperative Hemorrhage ◽  
Amyloid Angiopathy ◽  
Increased Risk ◽  
Cerebral Amyloid

Amyloid angiopathy–associated intracerebral hemorrhage (ICH) comprises 12%–15% of lobar ICH in the elderly. This growing population has an increasing incidence of thrombolysis-related hemorrhages, causing the management of hemorrhages associated with cerebral amyloid angiopathy (CAA) to take center stage. A concise reference assimilating the pathology and management of this clinical entity does not exist. Amyloid angiopathy–associated hemorrhages are most often solitary, but the natural history often progresses to include multifocal and recurrent hemorrhages. Compared with other causes of ICH, patients with CAA-associated hemorrhages have a lower mortality rate but an increased risk of recurrence. Unlike hypertensive arteriolar hemorrhages that occur in penetrating subcortical vessels, CAA-associated hemorrhages are superficial in location due to preferential involvement of vessels in the cerebral cortex and meninges. This feature makes CAA-associated hemorrhages easier to access surgically. In this paper, the authors discuss 3 postulates regarding the pathogenesis of amyloid hemorrhages, as well as the established clinicopathological classification of amyloid angiopathy and CAA-associated ICH. Common inheritance patterns of familial CAA with hemorrhagic strokes are discussed along with the role of genetic screening in relatives of patients with CAA. The radiological characteristics of CAA are described with specific attention to CAA-associated microhemorrhages. The detection of these microhemorrhages may have important clinical implications on the administration of anticoagulation and antiplatelet therapy in patients with probable CAA. Poor patient outcome in CAA-associated ICH is associated with dementia, increasing age, hematoma volume and location, initial Glasgow Coma Scale score, and intraventricular extension. The surgical management strategies for amyloid hemorrhages are discussed with a review of published surgical case series and their outcomes with a special attention to postoperative hemorrhage.

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