The QT Variability Index: A Multidimensional Approach to Understanding Cardiovascular Disease

Cardiology ◽  
2011 ◽  
Vol 118 (1) ◽  
pp. 42-44 ◽  
Author(s):  
Gianfranco Piccirillo ◽  
Pietro Rossi ◽  
Damiano Magrì
2012 ◽  
Vol 2012 ◽  
pp. 1-9 ◽  
Author(s):  
Damiano Magrì ◽  
Gianfranco Piccirillo ◽  
Raffaele Quaglione ◽  
Annalaura Dell’Armi ◽  
Marilena Mitra ◽  
...  

Emotionally charged events are associated with an increased risk of sudden cardiac death (SCD). In this study we assessed RR and QT variability index (QTVI) at baseline during anger recall test (AR). We calculated QTVI from a 5-min ECG recording and from a 10-beats segment around the presumed maximum sympathetic activation in thirty post-myocardial infarction patients under β-blocker therapy and 10 controls underwent. In all groups, the low-frequency component of RR and SBP increased during AR. In all recordings, the QTVI calculated on a 5-min ECG recording and the were higher in patients than in controls (P < 0.05). The QTVI during AR remained unchanged from baseline within each group. Conversely, during AR, the in controls diminished significantly (P < 0.05) from baseline whereas in patients remained unchanged. The inability to buffer an acute stress-induced increase in sympathetic activity could explain why events charged with acute stress are associated with an increased risk of ventricular arrhythmias in this setting of patients and support the role of cognitive behavior stress management strategies.


2018 ◽  
Vol 39 (5) ◽  
pp. 902-905 ◽  
Author(s):  
Arisa Kojima ◽  
Tadayoshi Hata ◽  
Tsuneaki Sadanaga ◽  
Yuri Mizutani ◽  
Hidetoshi Uchida ◽  
...  

Author(s):  
Hariton Costin ◽  
Steffen Schulz ◽  
Karl-Jurgen Bar ◽  
Ioana Alexa ◽  
Felix Adochiei ◽  
...  

2004 ◽  
Vol 107 (6) ◽  
pp. 583-588 ◽  
Author(s):  
Mats JOHANSSON ◽  
Sinsia A. GAO ◽  
Peter FRIBERG ◽  
Marita ANNERSTEDT ◽  
Göran BERGSTRÖM ◽  
...  

Patients with CRF (chronic renal failure) are at increased risk of cardiovascular diseases, and 60% of cardiovascular mortality in CRF is attributed to sudden death. Various abnormalities in myocardial repolarization are associated with the risk of ventricular arrhythmia. The aim of this study was to evaluate an index of temporal myocardial repolarization lability, the temporal QTVI (QT variability index), in patients with CRF. ECGs were recorded in 153 patients with CRF on haemodialysis (n=67), continuous ambulatory peritoneal dialysis (n=43) or conservative treatment (n=43) during 30 min of rest. QTVI was calculated as the logarithm of the ratio between the variances of the normalized QT and RR intervals. Age-matched healthy subjects (n=39) were examined for comparison. QTVI was increased by 47% in CRF patients compared with healthy subjects (−0.82±0.56 compared with −1.54±0.27 respectively; P<0.01). QTVI did not differ among patients on dialysis or conservative treatment, whereas QTVI was elevated further in patients with diabetes compared with non-diabetic CRF patients (−0.56±0.54 compared with −0.94±0.52 respectively; P<0.01). In a multiple linear regression analysis, diabetes and a history of coronary artery disease were the only independent predictors of QTVI in the CRF population. The present study demonstrates that elevated QTVI in patients with CRF is associated with diabetes and coronary disease. The present findings are important given that repolarization instability may predispose to ventricular arrhythmia and sudden death, events that occur frequently in CRF patients.


2016 ◽  
Vol Volume 11 ◽  
pp. 1687-1695 ◽  
Author(s):  
Gianfranco Piccirillo ◽  
Cristina Ottaviani ◽  
Claudia Fiorucci ◽  
Nicola Petrocchi ◽  
Federica Moscucci ◽  
...  

2014 ◽  
Vol 66 (3) ◽  
pp. 199 ◽  
Author(s):  
In Young Huh ◽  
Eun Sun Park ◽  
Kang-Il Kim ◽  
A-Ran Lee ◽  
Gyu-Sam Hwang

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