scholarly journals To Compare the Methods of Pregnancy Termination for Fetal Abnormality in the First and Second Trimesters

2012 ◽  
Vol 2012 ◽  
pp. 1-8 ◽  
Author(s):  
H. S. Wong
Keyword(s):  
Side Effects ◽  
Pregnancy Termination ◽  
Termination Of Pregnancy ◽  
Fetal Abnormality

Fetal abnormality is a major cause of termination of pregnancy and preservation of the fetus is important for confirmation of the diagnosis. Various regimes have been reported for termination of pregnancy for fetal abnormality in the first and the second trimesters. In this paper, we compare those regimes that allow preservation of the fetus, in terms of the efficacy in expulsion of the fetus, the factors and the side effects.

scholarly journals TERMINATION OF PREGNANCY

2009 ◽  
Vol 16 (02) ◽  
pp. 252-257
Author(s):  
UZMA HUSSAIN ◽  
FARZANA LATIF ◽  
TEHSEEN AKHTER
Keyword(s):  
Experimental Study ◽  
Side Effects ◽  
Dosage Regimen ◽  
Pregnancy Termination ◽  
Termination Of Pregnancy ◽  
Trimester Pregnancy ◽  
Sublingual Misoprostol ◽  
Quasi Experimental ◽  
Vaginal Misoprostol ◽  
Failed Induction

O b j e c t i v e : To compare the efficacy of vaginal misoprostal with that of sublingual misoprostol in 2n d trimester of pregnancyby comparing the induction-expulsion interval between two groups of patients induced with vaginal and sublingual misoprostol. S t u dyd e s i g n : Interventional, quasi experimental study. Settings: Obstetrics & Gynaecology Unit 1, Sir Ganga Ram Hospital, Lahore. Durationof s t u d y : Thirteen months from October 2006 to November 2007. S u b j e c t s a n d M e t h o d s : Sixty women at 12-26 weeks of gestation whichwere selected for termination of pregnancy were assigned into two groups. Thirty women received sublingual misoprostol and thirty womenreceived vaginal misoprostol. Dosage regimen was tablet Misoprostol 200fjg 4 hours apart till expulsion of fetus (maximum 5 doses). Mainoutcome measures were: 1. Induction-expulsion intervals 2. Maternal side effects 3. Fever 4. Nausea/vomiting 5.Diarrhea. R e s u l t s : Meaninduction-expulsion interval in vaginal group was 11.8±8.3 hours and in the sublingual group was 12.8±8.5 hours. Percentage of completeexpulsion was 53.3% in both groups. Cases of failed induction in vaginal group were 10% and in sublingual group were 13.3%. One case(3.3%) of fever and two cases (6.6%) of vomiting were observed in sublingual group and one case (3.3%) of vomiting was observed invaginal group. C o n c l u s i o n : Both routes appear to be equally efficacious for mid trimester pregnancy termination, without significant sideeffects.

scholarly journals Study to compare the effectiveness of intravaginal misoprostol alone with combined use of intravaginal misoprostol and intracervical foley’s catheter for termination of mid trimester pregnancy

2020 ◽  
Vol 9 (6) ◽  
pp. 2560
Author(s):  
Puneeta Mahajan ◽  
Neeraj Sharma ◽  
Parwati Sharma
Keyword(s):  
Side Effects ◽  
Pregnancy Termination ◽  
Foley Catheter ◽  
Tertiary Care ◽  
Termination Of Pregnancy ◽  
Combination Group ◽  
Main Concern ◽  
Tertiary Care Centre ◽  
Trimester Pregnancy ◽  
Foley’S Catheter

Background: The main concern of obstetrician is to provide the most effective and safest regimen for mid trimester termination of pregnancy which combines the shortest expulsion interval with least side effects. The combination of intravaginal misoprostol and intracervical Foley catheter for second trimester pregnancy termination has been described in previous studies with conflicting results. Hence gap exists in literature and not adequate evidence available so this study is undertaken.Methods: A prospective and interventional randomized comparative study was conducted in the department of obstetrics and gynecology, tertiary care centre, New Delhi. A total 60 pregnant female of 14 to 20 weeks of gestation who were admitted for termination of pregnancy due to any indication included in the study. Patients were divided into two groups (30 patients in each group). Group A (misoprostol and foleys combination group) and Group B (misoprostol group). Quantitative variables were compared with unpaired t-test/Mann-whitney test (when the data sets were not normally distributed) between the two groups and qualitative variables were compared by using chi-square test/Fisher’s exact test.Results: The mean induction to abortion interval was 18.31±1.95 hours in the female where misoprostol and foleys combination was used and 21.90±2.62 hours in the women where misoprostol alone used group. Authors found a significant reduction in induction to expulsion time in misoprostol and foleys combination group as compared to misoprostol alone group for mid-trimester termination of pregnancy. Total required dose of misoprostol use for termination of pregnancy was significantly less (p 0.008) in the women where both misoprostol and foleys was used than misoprostol alone.Conclusions: With the use of intracervical Foley’s catheter, the duration from induction to expulsion of abortus gets shortened and required dose of misoprostol is also reduced without any significant increase of side effects.

scholarly journals Role and efficacy of vaginal dinoprostone gel (PGE2) plus vaginal misoprostol (PGE1) in second trimester termination of pregnancy

2018 ◽  
Vol 7 (3) ◽  
pp. 888
Author(s):  
Abhijeet Kumar ◽  
Raju Agarwal
Keyword(s):  
Side Effects ◽  
Failure Rate ◽  
Pregnancy Termination ◽  
Termination Of Pregnancy ◽  
Second Trimester ◽  
Trimester Abortion ◽  
Trimester Pregnancy ◽  
Second Trimester Pregnancy ◽  
Second Trimester Abortion ◽  
Vaginal Misoprostol

Background: The addition of dinoprostone gel (PGE2) to standard regimen of second trimester abortion using vaginal misoprostol (PGE1) reduces failure rate and decrease induction abortion time interval. We evaluated the role and efficacy of vaginal dinoprostone gel with vaginal misoprostol in women undergoing second trimester abortion. Objective of present study was to assess the safety and effectiveness of vaginal dinoprostone gel plus vaginal misoprostol for second trimester termination of pregnancy.Methods: This study was a prospective cohort involving 100 women with 12-20 weeks gestation requesting termination of pregnancy. In study group 0.5mg dinoprostone gel applied vaginally followed by 400µg misoprostol every four hourly (max 3 doses) after six hours of dinoprostone gel application. The mean age of the women study was 27.2 years and mean gestational age was 18.9 weeks. The primary effectiveness of the study was the efficacy of the treatment to terminate pregnancy at 20 hrs. Secondary outcomes were induction abortion interval, failure rate, side effects. statistical analysis of study was carried out using chi square test.Results: At 20 hours, the complete abortion rate was 100%. Within 16 hours 98% women aborted without any significant side effects. Mean induction abortion interval was 14.56 hours.Conclusions: Combination of vaginal dinoprostone gel (PGE2) plus misoprostol (PGE1) is effective, safe and alternate method for second trimester pregnancy termination with. In this protocol induction to abortion interval time is less as compared to other methods of second trimester pregnancy termination.

TERMINATION OF PREGNANCY LESS THAN 49 DAYS USING MIFEPRISTONE AND MISOPROSTOL

2011 ◽  
pp. 16-24
Author(s):  
Thi Kim Ngoc Do ◽  
Vu Quoc Huy Nguyen
Keyword(s):  
Abdominal Pain ◽  
Side Effects ◽  
Reproductive Health ◽  
Pregnant Women ◽  
Pregnancy Termination ◽  
Medical Abortion ◽  
Termination Of Pregnancy ◽  
Successful Pregnancy ◽  
Satisfaction Rate

Objectives: 1.To evaluate the effectiveness and safety of Mifepristone and Misoprostol in termination of pregnancy less than 49 days. 2. To evaluate the acceptability and side effects of that treatment scheme. Materials & Methods: 169 pregnant women less than <49 days demanding medical abortion at Can Tho Reproductive Health Center during the period of June 1st 2009 to May 30th 2010. Mifepristone 200mg was administered orally, followed by onsite monitoring during 30 minutes; Misoprostol 400 µg were administered orally 48 hours later by th facility at the center. Follow-up visit for 2 weeks was made after using Mifepristone. Results and Discussion: Rate of successful pregnancy termination was 95.3%. Mean duration between Mifepristone and Misoprostol use and abortion is 4.3 ± 3.7 hours. Satisfaction rate is 89.4%. Observed Mifepristone’s side effects include abdominal pain (35.8%), nausea (20.3%), and vomit (4.8%); Misoprostol’s side effects include abdominal pain (86.6%), nausea (33,7%), vomit (8,6%), fever/child, fatigue and diarrhea (7.5%). Conclusions: Mifepristone and Misoprostol are safe and highly effective for termination of pregnancy less than 49 days.

scholarly journals VP02.12: Pregnancy termination for fetal abnormality: a one‐year study

2020 ◽  
Vol 56 (S1) ◽  
pp. 60-61
Author(s):  
M.M. Martins ◽  
C. Costa ◽  
L. Ferreira ◽  
L. Carreira ◽  
J. Braga ◽  
...  
Keyword(s):  
Pregnancy Termination ◽  
Fetal Abnormality ◽  
One Year
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