TERMINATION OF PREGNANCY LESS THAN 49 DAYS USING MIFEPRISTONE AND MISOPROSTOL

2011 ◽  
pp. 16-24
Author(s):  
Thi Kim Ngoc Do ◽  
Vu Quoc Huy Nguyen
Keyword(s):  
Abdominal Pain ◽  
Side Effects ◽  
Reproductive Health ◽  
Pregnant Women ◽  
Pregnancy Termination ◽  
Medical Abortion ◽  
Termination Of Pregnancy ◽  
Successful Pregnancy ◽  
Satisfaction Rate

Objectives: 1.To evaluate the effectiveness and safety of Mifepristone and Misoprostol in termination of pregnancy less than 49 days. 2. To evaluate the acceptability and side effects of that treatment scheme. Materials & Methods: 169 pregnant women less than <49 days demanding medical abortion at Can Tho Reproductive Health Center during the period of June 1st 2009 to May 30th 2010. Mifepristone 200mg was administered orally, followed by onsite monitoring during 30 minutes; Misoprostol 400 µg were administered orally 48 hours later by th facility at the center. Follow-up visit for 2 weeks was made after using Mifepristone. Results and Discussion: Rate of successful pregnancy termination was 95.3%. Mean duration between Mifepristone and Misoprostol use and abortion is 4.3 ± 3.7 hours. Satisfaction rate is 89.4%. Observed Mifepristone’s side effects include abdominal pain (35.8%), nausea (20.3%), and vomit (4.8%); Misoprostol’s side effects include abdominal pain (86.6%), nausea (33,7%), vomit (8,6%), fever/child, fatigue and diarrhea (7.5%). Conclusions: Mifepristone and Misoprostol are safe and highly effective for termination of pregnancy less than 49 days.

scholarly journals Early Pregnancy Termination with Oral Mifepristone and Vaginal Misoprostol

2016 ◽  
Vol 27 (2) ◽  
pp. 44-49
Author(s):  
Rafat Nawaz ◽  
Kakali Saha
Keyword(s):  
Abdominal Pain ◽  
Side Effects ◽  
Early Pregnancy ◽  
Vaginal Bleeding ◽  
Average Duration ◽  
Pregnancy Termination ◽  
Medical Abortion ◽  
Ongoing Pregnancy ◽  
Skilled Attendance ◽  
Vaginal Misoprostol

Objective: To determine the efficacy, side effect and acceptability of medical abortion using mifepristone 200mg orally and misoprostol 800?g vaginally in patients less than 49 days of gestation.Materials and methods: Seventy six women who requested termination of pregnancy up to 49 days of gestation were administered 200mg mifepristone orally followed 48 hours later by 800?g of misoprostol per vaginally.Results: Ninty six percent (96%) women had complete abortion with this regimen. There was no ongoing pregnancy. The average duration of per vaginal bleeding was 12-13 days. There were some side effects, which include abdominal pain, vomiting, fever etc.Conclusion: This mifepristone-misoprostol regimen is highly effective in terminating pregnancy in women up to 49 days duration with minimum side effects and this medical method may be advisable to practice as an alternative to surgical procedure where adequate skilled attendance is lacking.Bangladesh J Obstet Gynaecol, 2012; Vol. 27(2) : 44-49

Impact of the Israeli Ministry of Health Cytomegalovirus Guidelines on the Local Pregnancy Outcome

2020 ◽  
pp. 1-6
Author(s):  
Marina Pekar-Zlotin ◽  
Anat Alufi Naim ◽  
Perry Eliassi Revivo ◽  
Nadav Kugler ◽  
Yaakov Melcer ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Telephone Survey ◽  
Pregnancy Termination ◽  
Maternal Serum ◽  
Cmv Infection ◽  
Ministry Of Health ◽  
Newborn Outcomes ◽  
Fetal Infection ◽  
Postnatal Outcome

<b><i>Objective:</i></b> In 2011, the Israeli Ministry of Health (MOH) published standard guidelines for the follow-up of pregnant women infected by CMV, recommending that amniocentesis be performed in cases of maternal serum viral seroconversion or abnormal sonographic findings suggestive of CMV, in order to prove fetal infection before electing for pregnancy termination. <b><i>Methods:</i></b> A retrospective cohort study was performed, describing 448 pregnant women from 2006 to 2017. We collected data from all women that elected to continue their pregnancies after seroconversion and also of those who chose to undergo pregnancy termination. Subsequently, a telephone survey was then conducted to record outcomes of the newborns of women with CMV seroconversion during pregnancy. <b><i>Results:</i></b> 325 (73%) women chose to continue their pregnancy, while 123 (27%) opted for termination of pregnancy. We found that pregnancy termination due to CMV infection was reduced by 7%, from 72 cases (32%) to 51 cases (25%) after the implementation of the MOH guidelines in 2011. In addition, 182/305 (60%) of women responded to our telephone questionnaire regarding newborn outcomes. Of these women, 45/305 (14%) reported complications, and no correlation was found between the prenatal findings and postnatal outcome among those who have responded to our survey. <b><i>Conclusion:</i></b> Implementation of the new MOH guidelines has reduced the rate of pregnancy termination, without increasing the rate of neonatal complications in Israel with a similar outcome of complication rate as reported in the literature.

scholarly journals Comparison of Medical Abortion with Manual Vacuum Aspiration in Termination of Pregnancy up to Nine Weeks

2020 ◽  
Vol 18 (1) ◽  
pp. 116-119
Author(s):  
Kanti Prabha Giri ◽  
Ganesh Dangal
Keyword(s):  
Vaginal Bleeding ◽  
Medical Abortion ◽  
First Trimester ◽  
Termination Of Pregnancy ◽  
Chi Square ◽  
Vacuum Aspiration ◽  
First Trimester Pregnancy ◽  
Manual Vacuum Aspiration ◽  
Comprehensive Abortion Care

Background: Nepal government has legalized abortion and approved both medical abortion and manual vacuum aspiration for first trimester pregnancy. However, there is inadequate evidence in our setup to comment on the acceptability and complications of medical abortion and manual vacuum aspiration for termination of pregnancy up to nine weeks of gestation. The objective of this study is to compare the reasons for termination of pregnancy, effectiveness and complications between medical abortion and manual vacuum aspiration in termination of pregnancy up to nine weeks.Methods: A comparative study was conducted among women requesting termination of pregnancy up to nine weeks of gestation in Comprehensive Abortion Care unit of Paropakar Maternity and Women’s Hospital. Women were kept in medical abortion and manual vacuum aspiration groups after they chose the method. They were advised for follow up in two weeks. Reasons for termination, effectiveness and complications of medical abortion and manual vacuum aspiration were compared using Chi square test.Results: In a total of 160 women, the most common reason for termination of pregnancy was completion of the family. In manual vacuum aspiration group 43 (58.9%) women had minimal per vaginal bleeding while 30 (40.54%) women in medical abortion group had per vaginal bleeding for 6-10 days (p <0.001). Rate of complete abortion in medical abortion group was 85.14% (n=63) and in manual vacuum aspiration group was 93.15% (n=68). Conclusions: The complications following medical abortion were higher than manual vacuum aspiration in termination of pregnancy up to nine weeks. Rate of completeness of abortion following manual vacuum aspiration is superior over medical abortion.Keywords: Manual vacuum aspiration; Medical abortion; Termination of pregnancy

scholarly journals SECOND TRIMESTER MEDICAL TERMINATION OF PREGNANCY. CHALLENGES OF IMPLEMENTATION

2017 ◽  
pp. 20-25
Author(s):  
S. V. Apresyan ◽  
V. I. Dimitrova ◽  
O. A. Slyusareva
Keyword(s):  
Side Effects ◽  
Medical Abortion ◽  
Late Complications ◽  
Termination Of Pregnancy ◽  
Economic Feasibility ◽  
Second Trimester ◽  
High Efficacy ◽  
Medical Termination Of Pregnancy ◽  
Medical Termination ◽  
Low Incidence

The article describes the specific features of termination of progressive uterine pregnancy in the II trimester. It was found that the efficacy of medical abortion in the II trimester of pregnancy is 94–98%. High efficacy, low incidence of side effects or early and late complications and economic feasibility demonstrate that the method is promising and safe; therefore, it can be recommended as a priority when choosing a method for medical termination of pregnancy in the II trimester.

scholarly journals A retrospective study of efficacy and cost efficiency of medical vs. surgical management of abortions in first trimester

2021 ◽  
Vol 10 (9) ◽  
pp. 3429
Author(s):  
Meetangi Agarwal ◽  
Sailatha Ramanujam ◽  
Anuradha C. Ramachandran
Keyword(s):  
Success Rate ◽  
Pregnancy Termination ◽  
Transvaginal Ultrasound ◽  
Cost Effective ◽  
Medical Abortion ◽  
First Trimester ◽  
Observational Research ◽  
Medical Termination ◽  
Significant Difference

Background: The aim of the study was to assess and comparatively evaluate the efficacy of different methods of first trimester abortions (medical, surgical) in terms of its safety, cost and effectiveness.Methods: We present a retrospective observational research study done at Chettinad hospital and research institute, Kelambakkam Chennai which included a total of 70 patients of first trimester abortions, in the period from June 2019 to June 2020. 55 patients were offered medical treatment (MTOP) and were followed up with a repeat scan after 2 weeks. In cases of failed medical abortion patient underwent curettage. Though, in some cases after an attempt at medical abortion, if the products didn’t expel at all within 48 hours, dilatation and evacuation was offered. Transvaginal ultrasound was performed to confirm the success of the treatment. In 15 cases who presented with incomplete abortion, surgical treatment (STOP) was offered. The outcomes considered were successful complete abortions, failed medical abortions, side effects and complications including blood transfusion.Results: The baseline characteristics of women were similar in both the groups like mean age, parity, history of previous termination of pregnancy (TOP). The success rate in MTOP was 67.2% and in STOP 100%.The amount of bleeding experienced was moderate to heavy in MTOP and minimal to moderate in STOP.37 women who underwent only medical termination who returned for the 2-week follow-up, the rate of complete pregnancy termination was 94% and for the remaining 2 women surgical intervention was required. In the surgical group, at the 2-week follow up, no woman underwent a repeat vacuum aspiration with an efficacy of 100%. No significant difference was found in the mean total cost for the medical and surgical groups after adding the subsequent costs (including additional manual vacuum evacuation).Conclusions: Medical termination of abortion should be preferred over surgical termination as it is safer, cost effective, with fewer complications and high success rate. 

scholarly journals Mifepristone and Oral Misoprostol for Early Medical Abortion

1970 ◽  
Vol 7 (2) ◽  
pp. 127-130 ◽  
Author(s):  
V Shrivastava ◽  
A Shrivastava
Keyword(s):  
Pregnant Women ◽  
Success Rate ◽  
Research Council ◽  
Medical Abortion ◽  
Termination Of Pregnancy ◽  
Medical Termination Of Pregnancy ◽  
Oral Misoprostol ◽  
Medical Termination ◽  
Health Research Council ◽  
Good Success Rate

Background: Combined mifepristone and misoprostol is the best method of medical termination of pregnancy. The study is undertaken to find out the success rate, acceptability, efficacy and patient satisfaction of medical abortion in pregnant women with 49 days of gestation. Methods: The pregnant women with amenorrhea of 49 days or less seeking termination of pregnancy received were studied. The 200 mg of oral mifepristone and followed 48 hours later with 600 microgram of oral misoprostol were given. Results: The success rate with the regime was 47 (94%) and 49 (98%) were satisfied. Weakness 24 (48%), Nausea 10 (20%), diarrhea 12 (25%), needing analgesic 4 (8%) were the side effects of the combined regime. Conclusions: Medical termination of pregnancy with combination of mifepristone and oral misoprostol has a good success rate. The side effect of the regimen in our setup is less and well accepted. Majority of the patient are satisfied with medical termination of pregnancy. Key words: medical abortion; misoprostol; mifepristone DOI: 10.3126/jnhrc.v7i2.3021 Journal of Nepal Health Research Council Vol.7(2) Apr 2009 127-130

scholarly journals Effectiveness of evidence based regimen for medical abortion over conventional methods

2017 ◽  
Vol 6 (3) ◽  
pp. 881
Author(s):  
Anitha K. Gopal ◽  
Sajini B. Sajini B. ◽  
Ganamurali S. ◽  
Beena Kumari R.
Keyword(s):  
Side Effects ◽  
Medical Abortion ◽  
Termination Of Pregnancy ◽  
Control Group ◽  
Severe Bleeding ◽  
Evidence Based ◽  
Medical Termination Of Pregnancy ◽  
Medical Termination ◽  
Vaginal Misoprostol ◽  
Experimental Group

Background: Medical abortion is a means of medical termination of pregnancy by drugs alone. This can be done upto 63 days using mifepristone and misoprostol tablets. For the conventional method, patient has to come to the hospital 3 times. In our study we reduced the interval between the drugs there by reducing the number of hospital visits. The objectives were to study the reduction of induction abortion interval following administration of evidence based regimen and to compare the proportion of patients developing complications in both the groups.Methods: It was a comparative study conducted at Department of Obstetrics and Gynecology, Govermnent MedicalCollege Kottayam, Kerala, India from May 2015 to November 2015.Results: The mean induction abortion interval in experimental group was 14.3 hours and in control group, it was 60.4 hours which was found to be statistically significant. Only 3 patients (7%) of experimental group had side effects whereas 12 patients. (17.4%) had side effects in the control group. Major side effects encountered were severe abdominal pain and severe bleeding per vaginum. Evidence based  regimen consist of administration of mifepristone 200mg and vaginal misoprostol 600µg 6 hours later for termination of pregnancy up to 63 days could reduce the induction abortion interval by 46 hours and had less side effects.Conclusions: As it reduces the induction abortion Interval and complications we feel that the evidence based regimen for Medical Termination of Pregnancy is superior to the FDA approved regimen.

scholarly journals To Compare the Methods of Pregnancy Termination for Fetal Abnormality in the First and Second Trimesters

2012 ◽  
Vol 2012 ◽  
pp. 1-8 ◽  
Author(s):  
H. S. Wong
Keyword(s):  
Side Effects ◽  
Pregnancy Termination ◽  
Termination Of Pregnancy ◽  
Fetal Abnormality

Fetal abnormality is a major cause of termination of pregnancy and preservation of the fetus is important for confirmation of the diagnosis. Various regimes have been reported for termination of pregnancy for fetal abnormality in the first and the second trimesters. In this paper, we compare those regimes that allow preservation of the fetus, in terms of the efficacy in expulsion of the fetus, the factors and the side effects.

scholarly journals Hepatic fascioliasis: case report and review

1996 ◽  
Vol 38 (1) ◽  
pp. 69-73 ◽  
Author(s):  
Salha Abdul-Hadi ◽  
Rosa Contretas ◽  
Claudio Tombazzi ◽  
Marta Alvarez ◽  
Maribel Melendez
Keyword(s):  
Abdominal Pain ◽  
Case Report ◽  
Side Effects ◽  
Clinical Manifestations ◽  
Documented Case ◽  
Human Fascioliasis ◽  
Oral Doses

A well documented case of hepatic fascioliasis (HF), successfully treated with triclabendazole, is reported. Predominant clinical manifestations were fever, marked eosinophilia and abdominal pain. Triclabendazole was given as two single oral doses of 10 mg/kg each. Neither side effects nor clinical or parasitological relapses were seen after three months of follow up Based on this experience and few other similar reports in the literature, triclabendazole might be a valid therapeutical alternative in the treatment of human fascioliasis.

scholarly journals TERMINATION OF PREGNANCY

2009 ◽  
Vol 16 (02) ◽  
pp. 252-257
Author(s):  
UZMA HUSSAIN ◽  
FARZANA LATIF ◽  
TEHSEEN AKHTER
Keyword(s):  
Experimental Study ◽  
Side Effects ◽  
Dosage Regimen ◽  
Pregnancy Termination ◽  
Termination Of Pregnancy ◽  
Trimester Pregnancy ◽  
Sublingual Misoprostol ◽  
Quasi Experimental ◽  
Vaginal Misoprostol ◽  
Failed Induction

O b j e c t i v e : To compare the efficacy of vaginal misoprostal with that of sublingual misoprostol in 2n d trimester of pregnancyby comparing the induction-expulsion interval between two groups of patients induced with vaginal and sublingual misoprostol. S t u dyd e s i g n : Interventional, quasi experimental study. Settings: Obstetrics & Gynaecology Unit 1, Sir Ganga Ram Hospital, Lahore. Durationof s t u d y : Thirteen months from October 2006 to November 2007. S u b j e c t s a n d M e t h o d s : Sixty women at 12-26 weeks of gestation whichwere selected for termination of pregnancy were assigned into two groups. Thirty women received sublingual misoprostol and thirty womenreceived vaginal misoprostol. Dosage regimen was tablet Misoprostol 200fjg 4 hours apart till expulsion of fetus (maximum 5 doses). Mainoutcome measures were: 1. Induction-expulsion intervals 2. Maternal side effects 3. Fever 4. Nausea/vomiting 5.Diarrhea. R e s u l t s : Meaninduction-expulsion interval in vaginal group was 11.8±8.3 hours and in the sublingual group was 12.8±8.5 hours. Percentage of completeexpulsion was 53.3% in both groups. Cases of failed induction in vaginal group were 10% and in sublingual group were 13.3%. One case(3.3%) of fever and two cases (6.6%) of vomiting were observed in sublingual group and one case (3.3%) of vomiting was observed invaginal group. C o n c l u s i o n : Both routes appear to be equally efficacious for mid trimester pregnancy termination, without significant sideeffects.

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