scholarly journals The Association between Alcohol Dependence and Depression before and after Treatment for Alcohol Dependence

2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
Mary W. Kuria ◽  
David M. Ndetei ◽  
Isodore S. Obot ◽  
Lincoln I. Khasakhala ◽  
Betty M. Bagaka ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Major Depression ◽  
Alcohol Dependence ◽  
Treatment Process ◽  
Prevalence Of Depression ◽  
Before And After ◽  
Audit Score ◽  
Alcohol Detoxification ◽  
The Mean ◽  
Alcohol Dependent

The presence of depression in alcohol-dependent persons is likely to influence treatment process and outcomes. Identification of depression is important though not every depressed alcohol-dependent person requires treatment with antidepressants. Understanding the association between depression and alcohol dependence is essential for proper management of alcohol dependence. Objectives. To determine the prevalence of depression among alcohol-dependent persons before and after alcohol detoxification and rehabilitation. Design. Clinical trial with pre-/postmeasurements. Method. The CIDI and WHO-ASSIST were administered to 188 alcohol-dependent persons at intake and after six months. A researcher-designed sociodemographic questionnaire was also administered at intake. Results. The prevalence of depression among alcohol-dependent persons is high (63.8%) with a significant association between depression and the mean AUDIT score. At posttest, depressed participants had a statistically significant craving for alcohol. Conclusion. Alcohol dependence is associated with major depression.

Marital Satisfaction Among Spouses of Male Patients with Alcohol Dependence Syndrome

2019 ◽  
Vol 2 (02) ◽  
pp. 8-13
Author(s):  
Humayoon Akbar ◽  
Sudhakar S. ◽  
Shanthi B. ◽  
Khadeja Bi ◽  
Jayaseelan R. ◽  
...  
Keyword(s):  
Marital Satisfaction ◽  
Alcohol Dependence ◽  
Rural Areas ◽  
Tertiary Care ◽  
College Hospital ◽  
Medical College ◽  
Alcohol Dependence Syndrome ◽  
Male Patients ◽  
The Mean ◽  
Alcohol Dependent

BACKGROUND One third of Indians consume alcohol and there is an alarming annual increase in alcohol consumption. Majority of spouses of alcohol dependent males are also the primary care-takers of their husbands and are at risk of domestic violence. Marital dissatisfaction could reduce their involvement in getting their spouses treated for alcohol dependence. Our aim was to study the marital satisfaction among the spouses of patients with alcohol dependence. METHODOLOGY This study was conducted on spouses of male patients with alcohol dependence syndrome attending the psychiatry department of a tertiary care medical college hospital in Kanchipuram District in Tamilnadu. 200 consecutive male patients with alcohol dependence syndrome using the ICD 10 criteria were recruited. Severity of alcohol dependence was assessed using Short Alcohol Dependence Data (SADD). Marital satisfaction among the spouses was assessed using ENRICH Marital Satisfaction (EMS) Scale. Analysis of the data was done using Statistical Package for the Social Sciences (SPSS) version 22.0. RESULTS The mean age of alcohol dependent men and their spouses were 43.05±9.39 and 37.58±8.86 years respectively. Most of the spouses (83.5%) had done their primary education only and 50% were house-wives (unemployed). Majority of men earned between Rs.5000 to 10,000 and most of them were unskilled workers belonging to the lower socio-economic group in the rural areas. The mean SADD and EMS scores were 25.05 ± 8.891 and 31.76 ± 14.45 respectively. 74% of men in our study population were highly dependent on alcohol. Amongst the spouses of men with severe dependence 68.9% reported moderate and 28.3% reported low marital satisfaction. DISCUSSION and CONCLUSION Majority of alcohol dependent men suffered from severe dependence. An inverse relationship between marital satisfaction scores and severity of alcohol dependence was observed. Alcohol dependence and its severity was noted to have an adverse impact on marital satisfaction among spouses of the dependent patients.

scholarly journals The Effect of Dignity Therapy on Hope in Patients with Major Depression Disorder

2016 ◽  
Vol 8 (12) ◽  
pp. 118 ◽  
Author(s):  
Saeed Vaghee ◽  
Abbas Heydari
Keyword(s):  
Clinical Trial ◽  
Major Depression ◽  
Therapy Group ◽  
T Test ◽  
Control Group ◽  
Major Depression Disorder ◽  
Dignity Therapy ◽  
Therapy Effect ◽  
Before And After ◽  
Depression Disorder

<p><strong>INTRODUCTION:</strong> Despite the importance of the hope level increment in the patients with major depression disorder, fewer interventions have been applied to improve the hope level in the psychiatric patients, especially the depressed individuals.</p><p><strong>OBJECTIVE:</strong> To identify the dignity therapy effect on the hope level in the patients with major depression disorder.</p><p><strong>METHOD:</strong> In this random controlled clinical trial, 58 patients with major depression disorder, who were hospitalized in Ibn-e-Sina psychiatric hospital of Mashhad, were separated into two intervention (28 individuals) and control (30 individuals) groups. The intervention group has taken the dignity therapy (based on the standard protocol in three 30-45 minutes sessions) and the control group have been undertaken the normal caregiving without intervention. The research tool was the Herth hope index, which was filled exactly before and after intervention. The data analysis has been done by SPSS 11.5 and exact Fischer tests, Chi square, independent t-test and paired t-test.</p><p><strong>RESULTS:</strong> 65.5 percent of the patients were female and 34.5 percent were male. Before the intervention, there was no significant statistical difference between the dignity therapy group (19.9±2.8) and the control group (20.5±1.6) in the average total hope score (p=0.39). However, the variations of the average total hope score before and after intervention between the dignity therapy group (4.7±2.9) and the control group (0.1±1.9) was significant (p&lt;0.001).</p><p><strong>CONCLUSIONS:</strong> According to the dignity therapy effect on the hope level increment in patients with major depression disorder, this unique and short clinical trial can be employed to increase the hope level in the patients with depression disorder.</p>

scholarly journals A Seizure Attributed to Ofloxacine in a Woman Undergoing Detoxification for Alcohol Dependence

2009 ◽  
Vol 2009 ◽  
pp. 1-4 ◽  
Author(s):  
Pierre Lahmek ◽  
Laurent Michel ◽  
Nadine Meunier ◽  
Henri-Jean Aubin
Keyword(s):  
Alcohol Dependence ◽  
Previous History ◽  
Alcohol Withdrawal Syndrome ◽  
Prior History ◽  
Lower Urinary Tract Infection ◽  
Quinolone Antibiotics ◽  
History Of ◽  
Alcohol Detoxification ◽  
Oral Ofloxacin ◽  
Alcohol Dependent

Objective. To report one case of seizure following administration of ofloxacin.Case Summary. A 38-year-old woman with alcohol dependence but no prior history of seizure disorder admitted in our inpatient alcohol detoxification program was prescribed ofloxacin four days after admission for a lower urinary tract infection. She was currently prescribed diazepam 30 mg per day. This treatment was continued without modification following admission. Forty eight hours after starting ofloxacin and after receiving five doses of oral ofloxacin, the patient experienced a seizure. Ofloxacin treatment was stopped and no further seizures occurred. Neurological examination of the patient, laboratory tests, computerized tomography with contrast enhancement and electroencephalography did not detect any abnormalities. Up to the last consultation, six months after admission, the patient has reported no recurrence of the seizure.Discussion. Quinolone antibiotics vary in their ability to induce seizures, with ofloxacin having one of the least potentials. In the present case, the seizure could be attributed in all probability to taking ofloxacin; since she had no previous history of seizures, she did not present an alcohol withdrawal syndrome, benzodiazepine treatment was not modified, the seizure occurred 48 h after taking ofloxacin, but seven days after stopping drinking, no alternative aetiologies for the seizure could be identified and no seizure recurrence was reported over the following seven months. Of reported cases of seizures in patients treated with fluoroquinolones, none concerned patients with alcohol dependence or patients treated with benzodiazepines.Conclusions. The present case alerts us to the possibility that seizures may occur in alcohol dependent patients treated with benzodiazepines who concomitantly prescribed a fluoroquinolone. These widely-used antibiotics should thus be prescribed with caution to patients undergoing detoxification for alcohol dependence, particularly if they are also taking benzodiazepines, irrespective of whether they have a previous history of seizures or not.

D2 dopamine receptor (DRD2) polymorphism is associated with severity of alcohol dependence

2002 ◽  
Vol 17 (1) ◽  
pp. 17-23 ◽  
Author(s):  
J.P. Connor ◽  
R.McD. Young ◽  
B.R. Lawford ◽  
T.L. Ritchie ◽  
E.P. Noble
Keyword(s):  
Alcohol Dependence ◽  
Dopamine Receptor ◽  
Problem Drinking ◽  
Drinking Behavior ◽  
D2 Dopamine Receptor ◽  
Drd2 Gene ◽  
Allele Status ◽  
Alcohol Detoxification ◽  
Dependence Scale ◽  
Alcohol Dependent

SummaryThe A1 allele of the D2 dopamine receptor (DRD2) gene has been associated with alcohol dependence. However, the expression of this allele risk on the severity of drinking behavior in patients with alcohol dependence has not been systematically explored. The present study examines the association between DRD2 A1+(A1/A1 and A1/A2 genotypes) and A1– (A2/A2 genotype) allele status and key drinking parameters in alcohol-dependent patients. A sample of Caucasian adults was recruited from an alcohol detoxification unit. A clinical interview and the Alcohol Dependence Scale (ADS) questionnaire provided data on consumption, dependence, chronology of drinking and prior detoxification. A1+ allele compared to A1– allele patients consumed higher quantities of alcohol, commenced problem drinking at an earlier age, experienced a shorter latency between first introduction to alcohol to the onset of problem drinking and had higher ADS scores. Moreover, A1+ allele patients had more detoxification attempts than their A1– allele counterparts. In sum, alcohol-dependent patients with the DRD2 A1 allele compared to patients without this allele are characterized by greater severity of their disorder across a range of problem drinking indices. The implications of these findings are discussed.

Family Burden in Alcohol Dependence

2009 ◽  
Vol 24 (S1) ◽  
pp. 1-1 ◽  
Author(s):  
T. Paparrigopoulos ◽  
E. Tzavellas ◽  
D. Karaiskos ◽  
N. Stefanis ◽  
I. Mourikis ◽  
...  
Keyword(s):  
Alcohol Dependence ◽  
Interpersonal Relations ◽  
General Health Questionnaire ◽  
Family Burden ◽  
Published Data ◽  
Paired Samples ◽  
Alcohol Detoxification ◽  
Considerable Impact ◽  
Supportive Intervention ◽  
Alcohol Dependent

Objective:There are no published data on how family burden changes over time in alcoholism. We present 6-month follow-up data on the burden of families of alcohol dependent individuals.Methods:The sample comprised 87 caregivers (63 females, 24 males) of alcohol dependent individuals who completed a 4-6 week inpatient alcohol detoxification in the Specialized Drug and Alcohol Addiction Clinic at the Eginition Hospital, Athens University Medical School. During hospitalization, a brief supportive intervention for the relatives took place. After detoxification all participants were followed-up as outpatients for a 6-month period in an affiliated service. Burden and psychopathology of caregivers were assessed with the Burden of Care Scale, and the General Health Questionnaire (GHQ-28). T-tests for paired samples were used for comparisons between different time points (admission-discharge-six months). A logistic regression model was used to identify factors which influence relatives’ relief.Results:Caregivers exhibited high scores of burden in terms of financial, household, interpersonal relations and parental roles at admission; mild psychopathological symptoms were also recorded. By the end of detoxification scores significantly decreased in most relatives (admission vs. discharge, p< .000); this improvement was determined by the patients’ soberness.Conclusions:Alcohol dependence may have a considerable impact on family interaction as shown by the high scores of burden and mild psychopathology recorded in the caregivers. Our findings suggest that the relatives’ relief was dependent on the achievement of abstinence and the number of relapses. Therefore, a brief supportive intervention is recommended.

scholarly journals Comparing the Efficacy of Topical Metformin and Placebo in the Treatment of Melasma: A Randomized, Double-blind, Clinical Trial

2019 ◽  
pp. 1-8
Author(s):  
Mohammad Ali Mapar ◽  
Ali Asghar Hemmati ◽  
Ghazal Namdari
Keyword(s):  
Clinical Trial ◽  
Placebo Group ◽  
Double Blind ◽  
Laboratory Findings ◽  
Double Blind Clinical Trial ◽  
Metformin Group ◽  
Significant Difference ◽  
Before And After ◽  
P 16 ◽  
The Mean

Introduction: Generally affecting women, melasma is the acquired disorder of hyperpigmentation, and researches are still ongoing to find an effective, fast, and low-side-effect drug treating this disease. The present study is aimed at comparing the efficacy of topical metformin and placebo in the treatment of melasma. Methods: Sixty patients with melasma were treated in placebo and topical metformin recipient groups in a double-blind clinical trial. In addition to the demographic and laboratory findings of patients before and after the intervention, the MASI Score of patients in weeks 0, 4, 8, and 12 of the study and then one month after the study were analyzed using SPSS version 20 software. Results: The mean age of the studied patients was 35.25 ± 7.11 years. No significant difference was observed between the phenotypes (P= .49) and the type of melasma (P= .63) in the two groups. The mean MASI score of patients at the time of being included in the study in the placebo group was 10.47 ± 3.08; and in the metformin group, it was 11.93 ± 4.64 (P = .16). Compared to the beginning of the study, the MASI scores were significantly decreased in both groups of placebo (P = .00) and metformin (P = .00) one month after the end of the study; nevertheless, no statistically significant difference was observed between the MASI Scores of two groups in any of the study periods (P > .05). Conclusion: The results of the present study showed that metformin cream significantly declines the patients’ MASI score and does not have any effect on patients’ laboratory markers. Of course, no significant difference was observed between the MASI scores of the patients receiving metformin and the placebo group; however, the MASI score decrease trend continued until the 12th week; while in the placebo group, no significant decrease was seen after eight weeks.

scholarly journals N-Acetylcystein has Potential Effect to Reduce Haematological Abnormalities in HIV/AIDS Patients Undergoing ARV Treatment

2020 ◽  
Vol 10 (4-s) ◽  
pp. 197-200
Author(s):  
Filia Yuniza ◽  
Eddy Mart Salim ◽  
Nova Kurniati ◽  
Harun Hudari ◽  
Erial Bahar ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Placebo Group ◽  
Potential Effect ◽  
Aids Patients ◽  
Exclusion Criteria ◽  
Double Blind ◽  
Before And After ◽  
The Mean ◽  
Hematological Abnormalities ◽  
Hiv Aids

Aims: to determine the effect of NAC administration on hematological abnormalities in HIV/AIDS patients who are undergoing ARV treatment. Method: This was a pilot study using a double blind randomized clinical trial. A total of 32 subjects who met the inclusion and exclusion criteria were divided into 2 groups, namely placebo and NAC. Subjects in the NAC group were given NAC at a dose of 3x200 mg/day, while the placebo group was given lactose at a dose of 3x200 mg/day. Each group was given treatment for 12 weeks. Before and after treatment, subjects were examined for hematologic parameters. Results:  Most of subjects had normal hematological features. NAC administration did not have a significant effect on the mean levels of Hb, Ht, number of erythrocytes, leukocytes and platelets (p> 0.05). However, NAC administration can reduce the degree of anemia and improve the condition of thrombocytopenia, leukopenia and lymphopenia. Conclusion: NAC administration can reduce hematological abnormalities HIV/AIDS patients undergoing ARV treatment. Keywords: ARV, Hematological abnormalities, HIV/AIDS, NAC.

Diagnosis of Depression in Alcohol Dependence: Changes in Prevalence with Drinking Status

1995 ◽  
Vol 166 (2) ◽  
pp. 199-204 ◽  
Author(s):  
Kate M. Davidson
Keyword(s):  
Major Depression ◽  
Alcohol Dependence ◽  
Alcohol Intoxication ◽  
Demographic Variables ◽  
Antidepressant Treatments ◽  
Drinking Status ◽  
The Relationship ◽  
Alcohol Related Problems ◽  
Abstinence From Alcohol ◽  
Alcohol Dependent

BackgroundDepression and alcohol dependence are frequently found to co-exist but the relationship between these disorders requires further elucidation. This study tested several hypotheses related to the relevance of whether the diagnosis of depression was made before admission or after detoxification in the current episode for those with alcohol dependence.MethodThe Schedule for Affective Disorders and Schizophrenia (SADS) was administered to obtain Research Diagnostic Criteria (RDC) on 82 randomly selected alcohol dependent in-patients. Alcohol-related (Severity of Alcohol Dependence Questionnaire (SADQ), alcohol consumption and alcohol-related problems), socio-demographic variables and treatment for depression were assessed.ResultsFor the episode of drinking which led to admission, a diagnosis of major depression was found in the majority of patients (67%). Once detoxification from alcohol took place, only the minority (13%) met criteria for major depression.ConclusionsIt is suggested that depression is largely associated with the episode of drinking which led to admission in patients who are dependent on alcohol and may be due to the effect of chronic alcohol intoxication. Socio-demographic and alcohol-related characteristics appear to bear little relation to the presence of depression. Clinicians exercise appropriate judgement in not prescribing antidepressant treatments to patients whose depression may remit with abstinence from alcohol.

scholarly journals Effect of nutrition education on weight gain and macronutrients intake during pregnancy: a randomized clinical trial

2020 ◽  
Vol 22 (2) ◽  
pp. 61-66
Author(s):  
Masoomeh Goodarzi Khoigani ◽  
Azadeh Nadjarzadeh ◽  
Farahnaz Mardanian ◽  
Roya Riahi ◽  
Nahid Ardian ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Weight Gain ◽  
Pregnant Women ◽  
Nutrition Education ◽  
Protein Intake ◽  
Intervention Group ◽  
Fat Intake ◽  
Dietary Fiber Intake ◽  
Before And After ◽  
The Mean

Background and aims: The imbalance between energy intake and consumption has been recognized as an important factor contributing to the gestational weight gain (GWG). Additionally, the determination of the effect of macronutrient composition on GWG has been recommended by researchers. Therefore, we examined the effect of nutrition education on weight gain, energy, and energy-adjusted macronutrients intake during three trimesters of pregnancy which have not been widely studied. Methods: This randomized single-blinded clinical trial was performed on 192 primiparous pregnant women in Isfahan, Iran, from May 2015 to September 2016. Data were collected using a questionnaire completed through interviews with pregnant women and prenatal care-related records. We developed an individualized calorie-appropriate diet for each participant at enrollment and then three 45-60 minute training sessions were held at 6-10, 18, and 26 weeks of pregnancy and the subjects’ weights were measured during these sessions. A consecutive 3-day food intake record at 6-10, 18 and 34-36 weeks was obtained from two groups to determine the macronutrients. Moreover, physical activity scores were estimated before and after the intervention. Results: The mean weights at 18, 26, and 40 weeks of gestation were significantly lower in the intervention group ( P=0.024, P=0.040, and P=0.015, respectively). The total energy, energy-adjusted carbohydrate and protein intake at 6-10, 18, and 34-36 weeks of gestation were not significantly different between the two groups (P >0.05). However, the mean energy-adjusted fat intake decreased ( P=0.043). In addition, the mean energy-adjusted dietary fiber intake was significantly higher in the intervention group ( P=0.001). Conclusion: In the present individualized calorie-appropriate trial, the mean weights decreased during three trimesters in the intervention group. Additionally, calorie, energy-adjusted carbohydrate and protein intake did not change after intervention while energy-adjusted fat intake decreased.

scholarly journals Effect of Recitation of Tawassul Prayer on Anxiety and Physiological Parameters of Patients with Myocardial Infarction Admitted to Coronary Care Unit: A Randomized Clinical Trial

2021 ◽  
Keyword(s):  
Myocardial Infarction ◽  
Clinical Trial ◽  
Respiratory Rate ◽  
Intervention Group ◽  
Depression Scale ◽  
Physiological Parameters ◽  
Human Needs ◽  
Significant Difference ◽  
Before And After ◽  
The Mean

Background and Aims: Anxiety following acute myocardial infarction is a particularly important issue. Prayer is one of the basic human needs that is related to mental health. In this regard, this study aimed to determine the effect of recitation of Tawassul prayer on anxiety and physiological parameters of patients with myocardial infarction. Materials and Methods: This clinical trial was performed on 80 patients for 6 months from August 2017 to March 2018. They were selected by the targeted sampling method and randomly assigned to two groups with gender and age block randomization. The subjects were asked to complete the anxiety subscale of the Hospital Anxiety and Depression Scale. Physiologic parameters were measured and participants in the intervention group listened to the recitation of the Tawassul Prayer with headphones. Results: In the experimental group, the mean of anxiety scores before and after intervention were 11.17±3.06 and 5.81±3.16, respectively, which had a significant difference (P<0.001). There was a significant difference between the two groups in terms of the mean scores of anxiety before and after intervention (P<0.001) and the respiratory rate before and after intervention (P=0.025). Conclusion: Prayer affected the level of anxiety and respiratory rate. This prayer is useful for reducing anxiety and improving the respiratory rate in patients with myocardial infarction.

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