The role of RhoA GTPase activating protein DLC2 in painful diabetic neuropathy

2013 ◽  
Author(s):  
Lee Sean Tirrell
Keyword(s):  
Diabetic Neuropathy ◽  
Painful Diabetic Neuropathy ◽  
Gtpase Activating Protein ◽  
Rhoa Gtpase

Role of T-Type Ca2+ Channels in Painful Diabetic Neuropathy

2019 ◽  
Vol 51 (6) ◽  
pp. 455-461
Author(s):  
P. V. Belan ◽  
Y. M. Usachev ◽  
D. E. Duzhyy ◽  
S. Y. Ivanova ◽  
A. N. Tarasenko ◽  
...  
Keyword(s):  
Diabetic Neuropathy ◽  
Painful Diabetic Neuropathy ◽  
Ca2 Channels

scholarly journals Pathogenesis of Painful Diabetic Neuropathy

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Amir Aslam ◽  
Jaipaul Singh ◽  
Satyan Rajbhandari
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Neuropathic Pain ◽  
Diabetic Neuropathy ◽  
Peripheral Nerves ◽  
Daily Life ◽  
Painful Diabetic Neuropathy ◽  
Common Cause ◽  
The Central Nervous System

The prevalence of diabetes is rising globally and, as a result, its associated complications are also rising. Painful diabetic neuropathy (PDN) is a well-known complication of diabetes and the most common cause of all neuropathic pain. About one-third of all diabetes patients suffer from PDN. It has a huge effect on a person’s daily life, both physically and mentally. Despite huge advances in diabetes and neurology, the exact mechanism of pain causation in PDN is still not clear. The origin of pain could be in the peripheral nerves of the central nervous system. In this review, we discuss various possible mechanisms of the pathogenesis of pain in PDN. We discuss the role of hyperglycaemia in altering the physiology of peripheral nerves. We also describe central mechanisms of pain.

scholarly journals The Role of Gender in the Onset, Development and Impact of Type 2 Diabetes Mellitus and Its Co-Morbidities

2020 ◽  
Author(s):  
Féaron C. Cassidy ◽  
Sinead Lafferty ◽  
Cynthia M. Coleman
Keyword(s):  
Diabetes Mellitus ◽  
Cardiovascular Disease ◽  
Relative Risk ◽  
Diabetic Neuropathy ◽  
Physiological Mechanism ◽  
Painful Diabetic Neuropathy ◽  
Clear Cut ◽  
Gender Influences

Almost half a billion people worldwide are living with diabetes mellitus (DM). Complications associated with DM are common and approximately half of those people with DM suffer from at least one comorbidity. There is high mortality, morbidity and cost associated with these comorbidities which include cardiovascular disease, retinopathy, nephropathy, neuropathy and osteopathy. Gender influences the relative risk of developing complications from DM via differing mechanisms – both directly and indirectly. Generally, an increased relative risk of cardiovascular disease and kidney disease is noticed in women with DM compared to the non-DM context, where rates of both are much higher in men. Men appear to be at greater risk of diabetic retinopathy and also of insensate diabetic neuropathy, whereas women suffer from an increased rate of painful diabetic neuropathy compared to men. These differences are not clear cut and vary regionally and temporally, indicating that the field would benefit from further research on both the epidemiology and physiological mechanism of the observed patterns. These differences should be taken into account in treatment programmes for DM and its comorbidities.

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