The role of interferon-gamma inducible protein 10 (IP10) in early-phase graft injury induced late-phase cisplatin resistance after liver transplantation

2012 ◽  
Author(s):  
Wei Geng
Keyword(s):  
Liver Transplantation ◽  
Interferon Gamma ◽  
Early Phase ◽  
Cisplatin Resistance ◽  
Late Phase ◽  
Inducible Protein

THE POTENTIAL ROLE OF EARLY-PHASE GRAFT INJURY IN INDUCTION OF LATE-PHASE CHEMORESISTANCE AFTER LIVER TRANSPLANTATION

2010 ◽  
Vol 90 ◽  
pp. 269
Author(s):  
W. Geng ◽  
K. Man ◽  
Q. Cheng ◽  
K. T.P. Ng ◽  
X. B. Liu ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Early Phase ◽  
Potential Role ◽  
Late Phase

scholarly journals Role of QuantiFERON-TB Gold, Interferon Gamma Inducible Protein-10 and Tuberculin Skin Test in Active Tuberculosis Diagnosis

PLoS ONE ◽  
2010 ◽  
Vol 5 (2) ◽  
pp. e9051 ◽  
Author(s):  
Basirudeen Syed Ahamed Kabeer ◽  
Balambal Raman ◽  
Aleyamma Thomas ◽  
Venkatesan Perumal ◽  
Alamelu Raja
Keyword(s):  
Tuberculin Skin Test ◽  
Skin Test ◽  
Interferon Gamma ◽  
Active Tuberculosis ◽  
Tuberculosis Diagnosis ◽  
Inducible Protein

Chemical preconditioning with 3-nitropropionic acid in hearts: role of mitochondrial KATP channel

2001 ◽  
Vol 280 (5) ◽  
pp. H2406-H2411 ◽  
Author(s):  
Ramzi A. Ockaili ◽  
Peeyush Bhargava ◽  
Rakesh C. Kukreja
Keyword(s):  
Infarct Size ◽  
Early Phase ◽  
Ischemia Reperfusion ◽  
Late Phase ◽  
Saline Group ◽  
Risk Area ◽  
Nitropropionic Acid ◽  
Delayed Phase ◽  
3 Nitropropionic Acid

We investigated the cardioprotective effect of 3-nitropropionic acid (3-NPA), an inhibitior of mitochondrial succinate dehydrogenase, and we wanted to show whether this protection is mediated by of opening mitochondrial ATP-sensitive potassium (KATP) channels. Adult rabbits were treated with either 3-NPA (3 mg/kg iv) or saline ( n = 6 rabbits/group). After 30 min (for early phase) or 24 h (for late phase) of the treatment, the animals were subjected to 30 min of ischemia and 3 h of reperfusion (ischemia-reperfusion). 5-Hydroxydecanoate (5-HD, 5 mg/kg iv),the mitochondrial KATP channel blocker, was administered 10 min before ischemia-reperfusion in the saline- and 3-NPA-treated rabbits. 3-NPA caused a decrease in the infarct size from 27.8 ± 4.2% in the saline group to 16.5 ± 1.0% in the 3-NPA-treated rabbits during early phase and from 30.4 ± 4.2% in the saline group to 17.6 ± 1.05 in the 3-NPA group during delayed phase ( P < 0.05, % of risk area). The anti-infarct effect of 3-NPA was blocked by 5-HD as shown by an increase in infarct size to 33 ± 2.7% (early phase) and 31 ± 2.4% (delayed phase) ( P < 0.05 vs. 3-NPA groups). 5-HD had no proischemic effect in control animals. Also, 3-NPA had no effect on systemic hemodynamics. We conclude that 3-NPA induces long-lasting anti-ischemic effects via opening of mitochondrial KATP channels.

scholarly journals Evaluation of diagnostic role of IP-10 (Interferon Gamma Inducible Protein) and anti PGL-1 antibody in pediatric leprosy

2017 ◽  
Vol 4 (1) ◽  
pp. 76-81
Author(s):  
Dr. Raj Kamal ◽  
◽  
Dr. Rajeshwar Dayal ◽  
Dr. Madhu Singh ◽  
Dr K.K. Mohanty ◽  
...  
Keyword(s):  
Interferon Gamma ◽  
Diagnostic Role ◽  
Inducible Protein

scholarly journals Role of Egr1 on Pancreatic Endoderm Differentiation

Cell Medicine ◽  
2018 ◽  
Vol 10 ◽  
pp. 215517901773317
Author(s):  
Takako Tsugata ◽  
Naruo Nikoh ◽  
Tatsuya Kin ◽  
Chika Miyagi-Shiohira ◽  
Yoshiki Nakashima ◽  
...  
Keyword(s):  
Stem Cells ◽  
Pluripotent Stem Cells ◽  
Early Phase ◽  
Late Phase ◽  
Embryonic Stem ◽  
Clinical Implementation ◽  
Insulin Producing Cells ◽  
Low Efficiency

The low efficiency of in vitro differentiation of human embryonic stem cells (hESCs) or human-induced pluripotent stem cells (iPSCs) into insulin-producing cells is a crucial hurdle for the clinical implementation of human pluripotent stem cells (PSCs). Our previous investigation into the key factors for the differentiation of PSCs into insulin-producing cells suggested that the expression of GATA binding protein 6 (GATA6) and Gremlin 1 (GREM1) and inhibition of early growth response protein 1 (Egr1) may be important factors. In this study, we investigated the role of Egr1 in pancreas development. The transfection of small interfering RNA (siRNA) of Egr1 in the early phase induced the differentiation of iPSCs derived from fibroblasts (FiPSCs) into pancreatic endoderm and insulin-producing cells. In contrast, the downregulation of Egr1 in the late phase suppressed the differentiation of FiPSCs into pancreatic endoderm and insulin-producing cells. In addition, the overexpression of Egr1 suppressed the differentiation of iPSCs derived from pancreatic cells into pancreatic endoderm and insulin-producing cells. These data suggest that the downregulation of Egr1 in the early phase can efficiently induce the differentiation of iPSCs into insulin-producing cells.

scholarly journals Dual role of MUC1 mucin in kidney ischemia-reperfusion injury: Nephroprotector in early phase, but pro-fibrotic in late phase

2017 ◽  
Vol 1863 (6) ◽  
pp. 1336-1349 ◽  
Author(s):  
Jean-Baptiste Gibier ◽  
Brigitte Hémon ◽  
Mélanie Fanchon ◽  
Kelly Gaudelot ◽  
Nicolas Pottier ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Early Phase ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Late Phase ◽  
Dual Role ◽  
Muc1 Mucin ◽  
Kidney Ischemia
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