scholarly journals Interferon-gamma inducible protein 10 (IP10) induced cisplatin resistance of HCC after liver transplantation through ER stress signaling pathway

Oncotarget ◽  
2015 ◽  
Vol 6 (29) ◽  
pp. 28042-28056 ◽  
Author(s):  
Wei Geng ◽  
Chung-Mau Lo ◽  
Kevin T.P. Ng ◽  
Chang-Chun Ling ◽  
Xiang Qi ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Er Stress ◽  
Signaling Pathway ◽  
Interferon Gamma ◽  
Cisplatin Resistance ◽  
Stress Signaling ◽  
Inducible Protein ◽  
Stress Signaling Pathway

scholarly journals Oxyresveratrol Induces Autophagy via the ER Stress Signaling Pathway, and Oxyresveratrol-Induced Autophagy Stimulates MUC2 Synthesis in Human Goblet Cells

Antioxidants ◽  
2020 ◽  
Vol 9 (3) ◽  
pp. 214
Author(s):  
Jiah Yeom ◽  
Seongho Ma ◽  
Young-Hee Lim
Keyword(s):  
Er Stress ◽  
Signaling Pathway ◽  
Expression Profiles ◽  
Peptide Mass Fingerprinting ◽  
Goblet Cells ◽  
Stress Signaling ◽  
Cell Protection ◽  
Peptide Mass ◽  
Muc2 Expression ◽  
Stress Signaling Pathway

Background: Autophagy is a cell protection system invoked to eliminate the damaged organelles and misfolded proteins that induce various stresses, including endoplasmic reticulum (ER) stress. Autophagy can control mucin secretion in goblet cells. Oxyresveratrol (OXY), an antioxidant, stimulates expression of MUC2. Thus, we investigated the effect of OXY on autophagy and found that OXY-induced autophagy stimulates MUC2 expression in human intestinal goblet cells. Methods: Autophagy-related genes and proteins were examined by quantitative real-time PCR (qPCR) and Western blotting, respectively. Autophagy was assessed by immunocytochemistry (ICC). To analyze the protein expression profiles of OXY-treated LS 174T goblet cells, two-dimensional electrophoresis (2DE) and peptide mass fingerprinting (PMF) were performed. MUC2 expression in cells was evaluated by ICC. Results: OXY significantly increased the expression levels of genes related to autophagy induction, and activated phagosome elongation resulted in the formation of autophagosomes. OXY also activated the ER stress signaling pathway and promoted MUC2 synthesis, which was inhibited by treatment with an autophagy inhibitor. Conclusion: OXY induces autophagy via the ER stress signaling pathway, and OXY-induced autophagy increases MUC2 production in intestinal goblet cells.

scholarly journals Activated Ask1-MKK4-p38MAPK/JNK Stress Signaling Pathway in Human Omental Fat Tissue May Link Macrophage Infiltration to Whole-Body Insulin Sensitivity

2009 ◽  
Vol 30 (4) ◽  
pp. 412-412
Author(s):  
Matthias Blüher ◽  
Nava Bashan ◽  
Iris Shai ◽  
Ilana Harman-Boehm ◽  
Tanya Tarnovscki ◽  
...  
Keyword(s):  
Insulin Sensitivity ◽  
Signaling Pathway ◽  
Macrophage Infiltration ◽  
Whole Body ◽  
Stress Signaling ◽  
Fat Tissue ◽  
Omental Fat ◽  
Stress Signaling Pathway
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