Pathogenesis of congenital cataract in a gamma-crystallin mutant mouse model

2012 ◽  
Author(s):  
Chung-nga Tam
Keyword(s):  
Mouse Model ◽  
Congenital Cataract ◽  
Mutant Mouse ◽  
Gamma Crystallin

scholarly journals Impaired neurogenesis in the hippocampus of an adult VPS35 mutant mouse model of Parkinson's disease through interaction with APP

2021 ◽  
Vol 153 ◽  
pp. 105313
Author(s):  
Mei Jiang ◽  
Hai-Tao Tu ◽  
Ke Zhang ◽  
Wei Zhang ◽  
Wei-Ping Yu ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Mouse Model ◽  
Mutant Mouse ◽  
Impaired Neurogenesis

Dietary Garcinol Arrests Pancreatic Cancer in p53 and K-ras Conditional Mutant Mouse Model

2018 ◽  
Vol 70 (7) ◽  
pp. 1075-1087 ◽  
Author(s):  
Nadia Saadat ◽  
Sarah Akhtar ◽  
Arvind Goja ◽  
Nurul H. Razalli ◽  
Andreea Geamanu ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Mouse Model ◽  
Mutant Mouse ◽  
Conditional Mutant

scholarly journals Rad51c- and Trp53-double-mutant mouse model reveals common features of homologous recombination-deficient breast cancers

Oncogene ◽  
2016 ◽  
Vol 35 (35) ◽  
pp. 4601-4610 ◽  
Author(s):  
M Tumiati ◽  
P M Munne ◽  
H Edgren ◽  
S Eldfors ◽  
A Hemmes ◽  
...  
Keyword(s):  
Homologous Recombination ◽  
Mouse Model ◽  
Double Mutant ◽  
Mutant Mouse ◽  
Breast Cancers ◽  
Common Features ◽  
Double Mutant Mouse

Abstract 68: Tumor operational signaling pathways in an Nf1 mutant mouse model system

2014 ◽  
Author(s):  
Steve Braunstein ◽  
Rana Mroue ◽  
Brian Huang ◽  
Sourav Bandyopadhyay ◽  
Jean Nakamura
Keyword(s):  
Mouse Model ◽  
Signaling Pathways ◽  
Mutant Mouse ◽  
Model System ◽  
Mouse Model System

scholarly journals Effects of Alcohol and Cocaine in a Mutant Mouse Model of Predisposition to Post-Traumatic Stress Disorder

2020 ◽  
Vol 11 ◽  
Author(s):  
Eleni Paizanis ◽  
Michela Crotti ◽  
Anthony Petit ◽  
Mathilde Règue ◽  
Virginie Beray-Berthat ◽  
...  
Keyword(s):  
Mouse Model ◽  
Post Traumatic Stress Disorder ◽  
Traumatic Stress ◽  
Mutant Mouse ◽  
Stress Disorder ◽  
Post Traumatic Stress ◽  
Post Traumatic

Spotlight on a mouse model of obsessive-compulsive disorder

2013 ◽  
Vol 28 (S2) ◽  
pp. 17-17
Author(s):  
E. Burguière
Keyword(s):  
Basal Ganglia ◽  
Mouse Model ◽  
Obsessive Compulsive Disorder ◽  
Response Inhibition ◽  
Mutant Mouse ◽  
Repetitive Behavior ◽  
Inhibitory Neurons ◽  
Obsessive Compulsive ◽  
Repetitive Behaviour ◽  
Compulsive Disorder

It has been shown these last years that optogenetic tool, that uses a combination of optics and genetics technics to control neuronal activity with light on behaving animals, allows to establish causal relationship between brain activity and normal or pathological behaviors [3]. In combination with animal model of neuropsychiatric disorder, optogenetic could help to identify deficient circuitry in numerous pathologies by exploring functional connectivity, with a specificity never reached before, while observing behavioral and/or physiological correlates. To illustrate the promising potential of these tools for the understanding of psychiatric diseases, we will present our recent study where we used optogenetic to block abnormal repetitive behavior in a mutant mouse model of obsessive-compulsive disorder [1]. Using a delay-conditioning task we showed that these mutant mouse model had a deficit in response inhibition that lead to repetitive behaviour. With optogenetic, we could stimulate a specific circuitry in the brain that connect the orbitofrontal cortex with the basal ganglia; a circuitry that has been shown to be dysfunctional in compulsive behaviors. We observed that these optogenetic stimulations, through their effect on inhibitory neurons of the basal ganglia, could restore the behavioral response inhibition and alleviate the compulsive behavior. These findings raise promising potential for the design of targeted deep brain stimulation therapy for disorders involving excessive repetitive behavior and/or for the optimization of already existing stimulation protocol [2].

Sign in / Sign up

Export Citation Format

Share Document