Treatment of intracerebral hemorrhage with self-assembling paptide nanofiber scaffold and neural stem cells in both normotensive and hypertensive rats

2010 ◽  
Author(s):  
Yanhua Sang
Keyword(s):  
Stem Cells ◽  
Intracerebral Hemorrhage ◽  
Neural Stem Cells ◽  
Hypertensive Rats ◽  
Nanofiber Scaffold ◽  
Self Assembling

Brain Transplantation of Immortalized Human Neural Stem Cells Promotes Functional Recovery in Mouse Intracerebral Hemorrhage Stroke Model

Stem Cells ◽  
2007 ◽  
Vol 25 (5) ◽  
pp. 1204-1212 ◽  
Author(s):  
Hong J. Lee ◽  
Kwang S. Kim ◽  
Eun J. Kim ◽  
Hyun B. Choi ◽  
Kwang H. Lee ◽  
...  
Keyword(s):  
Stem Cells ◽  
Intracerebral Hemorrhage ◽  
Neural Stem Cells ◽  
Functional Recovery ◽  
Stroke Model ◽  
Human Neural Stem Cells

FGL-functionalized self-assembling nanofiber hydrogel as a scaffold for spinal cord-derived neural stem cells

2015 ◽  
Vol 46 ◽  
pp. 140-147 ◽  
Author(s):  
Jian Wang ◽  
Jin Zheng ◽  
Qixin Zheng ◽  
Yongchao Wu ◽  
Bin Wu ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Stem Cells ◽  
Neural Stem Cells ◽  
Self Assembling

scholarly journals Hypoxic preconditioning enhances neural stem cell transplantation therapy after intracerebral hemorrhage in mice

2016 ◽  
Vol 36 (12) ◽  
pp. 2134-2145 ◽  
Author(s):  
Takuma Wakai ◽  
Purnima Narasimhan ◽  
Hiroyuki Sakata ◽  
Eric Wang ◽  
Hideyuki Yoshioka ◽  
...  
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Intracerebral Hemorrhage ◽  
Neural Stem Cells ◽  
Cell Survival ◽  
Neural Stem Cell ◽  
Hypoxic Preconditioning ◽  
Neurological Deficits ◽  
Therapeutic Effects ◽  
Cell Recovery

Previous studies have shown that intraparenchymal transplantation of neural stem cells ameliorates neurological deficits in animals with intracerebral hemorrhage. However, hemoglobin in the host brain environment causes massive grafted cell death and reduces the effectiveness of this approach. Several studies have shown that preconditioning induced by sublethal hypoxia can markedly improve the tolerance of treated subjects to more severe insults. Therefore, we investigated whether hypoxic preconditioning enhances neural stem cell resilience to the hemorrhagic stroke environment and improves therapeutic effects in mice. To assess whether hypoxic preconditioning enhances neural stem cell survival when exposed to hemoglobin, neural stem cells were exposed to 5% hypoxia for 24 hours before exposure to hemoglobin. To study the effectiveness of hypoxic preconditioning on grafted-neural stem cell recovery, neural stem cells subjected to hypoxic preconditioning were grafted into the parenchyma 3 days after intracerebral hemorrhage. Hypoxic preconditioning significantly enhanced viability of the neural stem cells exposed to hemoglobin and increased grafted-cell survival in the intracerebral hemorrhage brain. Hypoxic preconditioning also increased neural stem cell secretion of vascular endothelial growth factor. Finally, transplanted neural stem cells with hypoxic preconditioning exhibited enhanced tissue-protective capability that accelerated behavioral recovery. Our results suggest that hypoxic preconditioning in neural stem cells improves efficacy of stem cell therapy for intracerebral hemorrhage.

scholarly journals Effect of Tongfu Xingshen capsule on the endogenous neural stem cells of experimental rats with intracerebral hemorrhage

2021 ◽  
Vol 24 (3) ◽  
Author(s):  
Zhizhong Cui ◽  
Shanshan Liu ◽  
Lingbo Hou ◽  
Yifan Sun ◽  
Haoxuan Chen ◽  
...  
Keyword(s):  
Stem Cells ◽  
Intracerebral Hemorrhage ◽  
Neural Stem Cells ◽  
Endogenous Neural Stem Cells

Therapeutic time window and effect of intracarotid neural stem cells transplantation for intracerebral hemorrhage

Neuroreport ◽  
2007 ◽  
Vol 18 (10) ◽  
pp. 1019-1023 ◽  
Author(s):  
Feng Li ◽  
Yuguang Liu ◽  
Shugan Zhu ◽  
Xuping Wang ◽  
Hongan Yang ◽  
...  
Keyword(s):  
Stem Cells ◽  
Intracerebral Hemorrhage ◽  
Neural Stem Cells ◽  
Time Window ◽  
Stem Cells Transplantation ◽  
Therapeutic Time Window
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