Brain Transplantation of Immortalized Human Neural Stem Cells Promotes Functional Recovery in Mouse Intracerebral Hemorrhage Stroke Model

Stem Cells ◽  
2007 ◽  
Vol 25 (5) ◽  
pp. 1204-1212 ◽  
Author(s):  
Hong J. Lee ◽  
Kwang S. Kim ◽  
Eun J. Kim ◽  
Hyun B. Choi ◽  
Kwang H. Lee ◽  
...  
Keyword(s):  
Stem Cells ◽  
Intracerebral Hemorrhage ◽  
Neural Stem Cells ◽  
Functional Recovery ◽  
Stroke Model ◽  
Human Neural Stem Cells

scholarly journals Transplantation of human neural stem cells into the stroke model

Nosotchu ◽  
2002 ◽  
Vol 24 (3) ◽  
pp. 355-358
Author(s):  
Osamu Honmou ◽  
Shinichi Oka ◽  
Masanori Sasaki ◽  
Akira Takahashi ◽  
Atsushi Tanooka ◽  
...  
Keyword(s):  
Stem Cells ◽  
Neural Stem Cells ◽  
Stroke Model ◽  
Human Neural Stem Cells

scholarly journals Exosomes derived from human neural stem cells stimulated by interferon gamma improve therapeutic ability in ischemic stroke model

2020 ◽  
Vol 24 ◽  
pp. 435-445 ◽  
Author(s):  
Guilong Zhang ◽  
Zhihan Zhu ◽  
Hong Wang ◽  
Yongbo Yu ◽  
Wanghao Chen ◽  
...  
Keyword(s):  
Stem Cells ◽  
Ischemic Stroke ◽  
Neural Stem Cells ◽  
Interferon Gamma ◽  
Stroke Model ◽  
Human Neural Stem Cells

scholarly journals Therapeutic Effect of BDNF-Overexpressing Human Neural Stem Cells (F3.BDNF) in a Contusion Model of Spinal Cord Injury in Rats

2021 ◽  
Vol 22 (13) ◽  
pp. 6970
Author(s):  
Da-Jeong Chang ◽  
Hwi-Young Cho ◽  
Seyoung Hwang ◽  
Nayeon Lee ◽  
Chunggab Choi ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Stem Cells ◽  
Spinal Cord Injury ◽  
Neural Stem Cells ◽  
Functional Recovery ◽  
Inflammatory Cells ◽  
Thoracic Spinal Cord ◽  
Human Neural Stem Cells ◽  
Neural Lineage ◽  
Cord Injury

The most common type of spinal cord injury is the contusion of the spinal cord, which causes progressive secondary tissue degeneration. In this study, we applied genetically modified human neural stem cells overexpressing BDNF (brain-derived neurotrophic factor) (F3.BDNF) to determine whether they can promote functional recovery in the spinal cord injury (SCI) model in rats. We transplanted F3.BDNF cells via intrathecal catheter delivery after a contusion of the thoracic spinal cord and found that they were migrated toward the injured spinal cord area by MR imaging. Transplanted F3.BDNF cells expressed neural lineage markers, such as NeuN, MBP, and GFAP and were functionally connected to the host neurons. The F3.BDNF-transplanted rats exhibited significantly improved locomotor functions compared with the sham group. This functional recovery was accompanied by an increased volume of spared myelination and decreased area of cystic cavity in the F3.BDNF group. We also observed that the F3.BDNF-transplanted rats showed reduced numbers of Iba1- and iNOS-positive inflammatory cells as well as GFAP-positive astrocytes. These results strongly suggest the transplantation of F3.BDNF cells can modulate inflammatory cells and glia activation and also improve the hyperalgesia following SCI.

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