Mechanisms of angiotensin II-induced renal fibrosis : role of TGF-β/SMAD signaling pathway

2009 ◽  
Author(s):  
Fuye Yang
Keyword(s):  
Angiotensin Ii ◽  
Signaling Pathway ◽  
Renal Fibrosis ◽  
Smad Signaling ◽  
Smad Signaling Pathway

scholarly journals Sirtuin 3 Activation by Honokiol Decreases Unilateral Ureteral Obstruction-Induced Renal Inflammation and Fibrosis via Regulation of Mitochondrial Dynamics and the Renal NF-κB-TGF-β1/Smad Signaling Pathway

2020 ◽  
Vol 21 (2) ◽  
pp. 402 ◽  
Author(s):  
Yi Quan ◽  
Woong Park ◽  
Jixiu Jin ◽  
Won Kim ◽  
Sung Kwang Park ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Ureteral Obstruction ◽  
Renal Fibrosis ◽  
Mitochondrial Dynamics ◽  
Unilateral Ureteral Obstruction ◽  
Sirtuin 3 ◽  
Smad Signaling ◽  
Renal Tubulointerstitial Fibrosis ◽  
Smad Signaling Pathway ◽  
Tgf Β1

Renal fibrosis is a common feature of all progressive chronic kidney diseases. Sirtuin 3 (SIRT3) is one of the mitochondrial sirtuins, and plays a role in the regulation of mitochondrial biogenesis, oxidative stress, fatty acid metabolism, and aging. Recently, honokiol (HKL), as a pharmaceutical SIRT3 activator, has been observed to have a protective effect against pressure overload-induced cardiac hypertrophy by increasing SIRT3 activity. In this study, we investigated whether HKL, as a SIRT3 activator, also has protective effects against unilateral ureteral obstruction (UUO)-induced renal tubulointerstitial fibrosis through SIRT3-dependent regulation of mitochondrial dynamics and the nuclear factor-κB (NF-κB)/transforming growth factor-β1 (TGF-β1)/Smad signaling pathway. We found that HKL decreased the UUO-induced increase in tubular injury and extracellular matrix (ECM) deposition in mice. HKL also decreased myofibroblast activation and proliferation in UUO kidneys and NRK-49F cells. Finally, we showed that HKL treatment decreased UUO-induced mitochondrial fission and promoted mitochondrial fusion through SIRT3-dependent effects. In conclusion, activation of SIRT3 via HKL treatment might have beneficial effects on UUO-induced renal fibrosis through SIRT3-dependent regulation of mitochondrial dynamics and the NF-κB/TGF-β1/Smad signaling pathway.

Emodin ameliorates renal fibrosis in rats via TGF-β1/Smad signaling pathway and function study of Smurf 2

2017 ◽  
Vol 50 (2) ◽  
pp. 373-382 ◽  
Author(s):  
Libin Ma ◽  
Hua Li ◽  
Shuchao Zhang ◽  
Xiaoling Xiong ◽  
Kean Chen ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Renal Fibrosis ◽  
Smad Signaling ◽  
Function Study ◽  
Smad Signaling Pathway ◽  
And Function ◽  
Tgf Β1

scholarly journals Role of Tenascin-X in regulating TGF-β/Smad signaling pathway in pathogenesis of slow transit constipation

2020 ◽  
Vol 26 (7) ◽  
pp. 717-724
Author(s):  
Yi-Chao Zhang ◽  
Bao-Xiang Chen ◽  
Xiao-Yu Xie ◽  
Yan Zhou ◽  
Qun Qian ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Slow Transit Constipation ◽  
Smad Signaling ◽  
Smad Signaling Pathway ◽  
Slow Transit ◽  
Transit Constipation

scholarly journals MicroRNA-140-5p Mediates Renal Fibrosis Through TGF-β1/Smad Signaling Pathway by Directly Targeting TGFBR1

2020 ◽  
Vol 11 ◽  
Author(s):  
Weitang Liao ◽  
Peifen Liang ◽  
Bo Liu ◽  
Zhenjian Xu ◽  
Lili Zhang ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Renal Fibrosis ◽  
Smad Signaling ◽  
Smad Signaling Pathway ◽  
Tgf Β1

The Role of the TGF/Smad Signaling Pathway in Peritoneal Fibrosis Induced by Peritoneal Dialysis Solutions

2008 ◽  
Vol 109 (2) ◽  
pp. e71-e78 ◽  
Author(s):  
Qiang Yao ◽  
Krzysztof Pawlaczyk ◽  
Ernesto Rodríguez Ayala ◽  
Arkadiusz Styszynski ◽  
Andrzej Breborowicz ◽  
...  
Keyword(s):  
Peritoneal Dialysis ◽  
Signaling Pathway ◽  
Peritoneal Fibrosis ◽  
Smad Signaling ◽  
Smad Signaling Pathway ◽  
Dialysis Solutions ◽  
Peritoneal Dialysis Solutions

scholarly journals Emodin Retarded Renal Fibrosis Through Regulating HGF and TGFβ–Smad Signaling Pathway

2020 ◽  
Vol Volume 14 ◽  
pp. 3567-3575
Author(s):  
Fan Yang ◽  
Lu Deng ◽  
JinPeng Li ◽  
MuHu Chen ◽  
Ying Liu ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Renal Fibrosis ◽  
Smad Signaling ◽  
Smad Signaling Pathway
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