Image-based monitoring and wavelet multi-rhythm analysis of long-term locomotor activity

2000 ◽  
Author(s):  
Baoming Wu
Keyword(s):  
Locomotor Activity ◽  
Rhythm Analysis

Long-term lithium treatment in rats attenuates m-chlorophenylpiperazine-induced decreases in food intake but not locomotor activity

1989 ◽  
Vol 98 (4) ◽  
pp. 448-452 ◽  
Author(s):  
Charanjit S. Aulakh ◽  
Joseph Zohar ◽  
Krystyna M. Wozniak ◽  
James L. Hill ◽  
Dennis L. Murphy
Keyword(s):  
Locomotor Activity ◽  
Food Intake ◽  
Lithium Treatment

scholarly journals Daily Rhythm of Tryptophan Hydroxylase-2 Messenger Ribonucleic Acid within Raphe Neurons Is Induced by Corticoid Daily Surge and Modulated by Enhanced Locomotor Activity

Endocrinology ◽  
2007 ◽  
Vol 148 (11) ◽  
pp. 5165-5172 ◽  
Author(s):  
Zeina S. Malek ◽  
Dominique Sage ◽  
Paul Pévet ◽  
Sylvie Raison
Keyword(s):  
Locomotor Activity ◽  
Tryptophan Hydroxylase ◽  
Mrna Levels ◽  
Median Raphe ◽  
Suprachiasmatic Nuclei ◽  
Master Clock ◽  
Median Raphé ◽  
Raphe Neurons ◽  
Adrenalectomized Rats

Tryptophan hydroxylase (TPH, the rate-limiting enzyme of serotonin synthesis) protein and mRNA levels display a circadian expression in the rat dorsal and median raphe. These patterns suggest a rhythmic synthesis of serotonin under the control of the master clock of suprachiasmatic nuclei. In the present study, we examined the involvement of endocrine and behavioral output signals of the master clock upon the Tph2 mRNA levels by quantitative in situ hybridization. In the absence of adrenals, a complete suppression of Tph2 mRNA rhythm was observed in dorsal and median raphe over 24 h. The restoration of corticosterone daily variations in adrenalectomized rats induced a Tph2 mRNA rhythmic pattern de novo, indicating that Tph2 mRNA rhythm is dependent upon daily fluctuations of glucocorticoids. Enhanced voluntary locomotor activity during 6 wk increased the level of Tph2 mRNA in both raphe nuclei of control rats without concomitant increase of corticosterone plasma levels. Moreover, this long-term enhanced locomotor activity was able to restore significant variation of Tph2 mRNA in adrenalectomized rats. In conclusion, both endocrine and behavioral cues can modulate Tph2 expression in dorsal and median raphe. The corticosterone surge acts as a rhythmic cue that induces the rhythmic expression of Tph2 in the raphe neurons. On the other hand, long-term exercise modulates the expression levels of this gene. Thus, the serotonin neurons are a target for both endocrine and behavioral circadian cues, and the serotoninergic input to the suprachiasmatic nuclei might feedback and influence the functioning of the clock itself.

scholarly journals Mouse Short- and Long-term Locomotor Activity Analyzed by Video Tracking Software

10.3791/50252 ◽  
2013 ◽  
Author(s):  
Jason M. York ◽  
Neil A. Blevins ◽  
Leslie K. McNeil ◽  
Gregory G. Freund
Keyword(s):  
Locomotor Activity ◽  
Video Tracking ◽  
Short And Long Term

scholarly journals dFRAME: A Video Recording-Based Analytical Method for Studying Feeding Rhythm in Drosophila

2021 ◽  
Vol 12 ◽  
Author(s):  
Mengxia Niu ◽  
Xiaohang Zhang ◽  
Weihan Li ◽  
Jianxun Wang ◽  
Yan Li
Keyword(s):  
Animal Model ◽  
Feeding Behavior ◽  
Analytical Method ◽  
Video Recording ◽  
Genetic Animal Model ◽  
Feeding Rhythm ◽  
Feeding Rhythms ◽  
Rhythm Analysis ◽  
Constant Dark

Animals, from insects to humans, exhibit obvious diurnal rhythmicity of feeding behavior. Serving as a genetic animal model, Drosophila has been reported to display feeding rhythms; however, related investigations are limited due to the lack of suitable and practical methods. Here, we present a video recording-based analytical method, namely, Drosophila Feeding Rhythm Analysis Method (dFRAME). Using our newly developed computer program, FlyFeeding, we extracted the movement track of individual flies and characterized their food-approaching behavior. To distinguish feeding and no-feeding events, we utilized high-magnification video recording to optimize our method by setting cut-off thresholds to eliminate the interference of no-feeding events. Furthermore, we verified that this method is applicable to both female and male flies and for all periods of the day. Using this method, we analyzed long-term feeding status of wild-type and period mutant flies. The results recaptured previously reported feeding rhythms and revealed detailed profiles of feeding patterns in these flies under either light/dark cycles or constant dark environments. Together, our dFRAME method enables a long-term, stable, reliable, and subtle analysis of feeding behavior in Drosophila. High-throughput studies in this powerful genetic animal model will gain great insights into the molecular and neural mechanisms of feeding rhythms.

scholarly journals The Effect of Chronic Methamphetamine Treatment on Schizophrenia Endophenotypes in Heterozygous Reelin Mice: Implications for Schizophrenia

Biomolecules ◽  
2020 ◽  
Vol 10 (6) ◽  
pp. 940
Author(s):  
Camilla Hume ◽  
Shelley Massey ◽  
Maarten van den Buuse
Keyword(s):  
Locomotor Activity ◽  
Social Behaviour ◽  
Social Preference ◽  
Term Effect ◽  
Spontaneous Locomotor Activity ◽  
Brain Dopamine ◽  
Locomotor Hyperactivity ◽  
Long Term Effect

Reelin has been implicated in the development of schizophrenia but the mechanisms involved in this interaction remain unclear. Chronic methamphetamine (Meth) use may cause dopaminergic sensitisation and psychosis and has been proposed to affect brain dopamine systems similarly to changes seen in schizophrenia. We compared the long-term effect of chronic Meth treatment between heterozygous reelin mice (HRM) and wildtype controls (WT) with the aim of better understanding the role of reelin in schizophrenia. Meth pretreatment induced sensitisation to the effect of an acute Meth challenge on locomotor activity, but it had no effect on baseline PPI or sociability and social preference. In all behavioural models, HRM did not significantly differ from WT at baseline, except spontaneous exploratory locomotor activity which was higher in HRM than WT, and sociability which was enhanced in HRM. Locomotor hyperactivity sensitisation was not significantly different between HRM and WT. Chronic Meth treatment reduced spontaneous locomotor activity to the level of WT. No deficits in PPI or social behaviour were induced by chronic Meth pretreatment in either strain. In conclusion, these data do not support a role of reelin in schizophrenia, at least not in HRM and in the methamphetamine sensitisation model.

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