Tissue specific expression studies on a vagal neural crest enhancer element of the mouse Hoxb3 gene in the development of the enteric nervous system

2000 ◽  
Author(s):  
Yuk-shan Chen
Keyword(s):  
Nervous System ◽  
Neural Crest ◽  
Enteric Nervous System ◽  
Specific Expression ◽  
Enhancer Element ◽  
Tissue Specific ◽  
Tissue Specific Expression ◽  
Expression Studies

scholarly journals Concerted evolution of human amylase genes.

1988 ◽  
Vol 8 (3) ◽  
pp. 1197-1205 ◽  
Author(s):  
D L Gumucio ◽  
K Wiebauer ◽  
R M Caldwell ◽  
L C Samuelson ◽  
M H Meisler
Keyword(s):  
Pancreatic Amylase ◽  
Amylase Gene ◽  
Salivary Amylase ◽  
Specific Expression ◽  
Enhancer Element ◽  
Tissue Specific ◽  
Tissue Specific Expression ◽  
Gene Copies ◽  
Amylase Genes ◽  
Sequence Elements

Cosmid clones containing 250 kilobases of genomic DNA from the human amylase gene cluster have been isolated. These clones contain seven distinct amylase genes which appear to comprise the complete multigene family. By sequence comparison with the cDNAs, we have identified two pancreatic amylase genes and three salivary amylase genes. Two truncated pseudogenes were also recovered. Intergenic distances of 17 to 22 kilobases separate the amylase gene copies. Within the past 10 million years, duplications, gene conversions, and unequal crossover events have resulted in a very high level of sequence similarity among human amylase gene copies. To identify sequence elements involved in tissue-specific expression and hormonal regulation, the promoter regions of the human amylase genes were sequenced and compared with those of the corresponding mouse genes. The promoters of the human and mouse pancreatic amylase genes are highly homologous between nucleotide -160 and the cap site. Two sequence elements thought to influence pancreas-specific expression of the rodent genes are present in the human genes. In contrast, similarity in the 5' flanking sequences of the salivary amylase genes is limited to several short sequence elements whose positions and orientations differ in the two species. Some of these sequence elements are also associated with other parotid-specific genes and may be involved in their tissue-specific expression. A glucocorticoid response element and a general enhancer element are closely associated in several of the amylase promoters.

scholarly journals Between Stress and Response: Function and Localization of Mechanosensitive Ca2+ Channels in Herbaceous and Perennial Plants

2021 ◽  
Vol 22 (20) ◽  
pp. 11043
Author(s):  
Félix P. Hartmann ◽  
Erwan Tinturier ◽  
Jean-Louis Julien ◽  
Nathalie Leblanc-Fournier
Keyword(s):  
Mechanical Stress ◽  
Regulatory Networks ◽  
Root Apex ◽  
Sequencing Data ◽  
Specific Expression ◽  
Tissue Specific ◽  
Practical Applications ◽  
Tissue Specific Expression ◽  
Expression Studies ◽  
Sense And Respond

Over the past three decades, how plants sense and respond to mechanical stress has become a flourishing field of research. The pivotal role of mechanosensing in organogenesis and acclimation was demonstrated in various plants, and links are emerging between gene regulatory networks and physical forces exerted on tissues. However, how plant cells convert physical signals into chemical signals remains unclear. Numerous studies have focused on the role played by mechanosensitive (MS) calcium ion channels MCA, Piezo and OSCA. To complement these data, we combined data mining and visualization approaches to compare the tissue-specific expression of these genes, taking advantage of recent single-cell RNA-sequencing data obtained in the root apex and the stem of Arabidopsis and the Populus stem. These analyses raise questions about the relationships between the localization of MS channels and the localization of stress and responses. Such tissue-specific expression studies could help to elucidate the functions of MS channels. Finally, we stress the need for a better understanding of such mechanisms in trees, which are facing mechanical challenges of much higher magnitudes and over much longer time scales than herbaceous plants, and we mention practical applications of plant responsiveness to mechanical stress in agriculture and forestry.

scholarly journals Hoxb3 vagal neural crest-specific enhancer element for controlling enteric nervous system development

2005 ◽  
Vol 233 (2) ◽  
pp. 473-483 ◽  
Author(s):  
Kwok Keung Chan ◽  
Yuk Shan Chen ◽  
Tai On Yau ◽  
Ming Fu ◽  
Vincent Chi Hang Lui ◽  
...  
Keyword(s):  
Nervous System ◽  
Neural Crest ◽  
Enteric Nervous System ◽  
System Development ◽  
Nervous System Development ◽  
Enhancer Element ◽  
Enteric Nervous System Development

Concerted evolution of human amylase genes

1988 ◽  
Vol 8 (3) ◽  
pp. 1197-1205
Author(s):  
D L Gumucio ◽  
K Wiebauer ◽  
R M Caldwell ◽  
L C Samuelson ◽  
M H Meisler
Keyword(s):  
Pancreatic Amylase ◽  
Amylase Gene ◽  
Salivary Amylase ◽  
Specific Expression ◽  
Enhancer Element ◽  
Tissue Specific ◽  
Tissue Specific Expression ◽  
Gene Copies ◽  
Amylase Genes ◽  
Sequence Elements

Cosmid clones containing 250 kilobases of genomic DNA from the human amylase gene cluster have been isolated. These clones contain seven distinct amylase genes which appear to comprise the complete multigene family. By sequence comparison with the cDNAs, we have identified two pancreatic amylase genes and three salivary amylase genes. Two truncated pseudogenes were also recovered. Intergenic distances of 17 to 22 kilobases separate the amylase gene copies. Within the past 10 million years, duplications, gene conversions, and unequal crossover events have resulted in a very high level of sequence similarity among human amylase gene copies. To identify sequence elements involved in tissue-specific expression and hormonal regulation, the promoter regions of the human amylase genes were sequenced and compared with those of the corresponding mouse genes. The promoters of the human and mouse pancreatic amylase genes are highly homologous between nucleotide -160 and the cap site. Two sequence elements thought to influence pancreas-specific expression of the rodent genes are present in the human genes. In contrast, similarity in the 5' flanking sequences of the salivary amylase genes is limited to several short sequence elements whose positions and orientations differ in the two species. Some of these sequence elements are also associated with other parotid-specific genes and may be involved in their tissue-specific expression. A glucocorticoid response element and a general enhancer element are closely associated in several of the amylase promoters.

Tissue-specific expression patterns of nuclear receptors

2013 ◽  
Author(s):  
AL Bookout ◽  
Y Jeong ◽  
M Downes ◽  
RT Yu ◽  
RM Evans ◽  
...  
Keyword(s):  
Nuclear Receptors ◽  
Expression Patterns ◽  
Specific Expression ◽  
Tissue Specific ◽  
Tissue Specific Expression
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