scholarly journals Hoxb3 vagal neural crest-specific enhancer element for controlling enteric nervous system development

2005 ◽  
Vol 233 (2) ◽  
pp. 473-483 ◽  
Author(s):  
Kwok Keung Chan ◽  
Yuk Shan Chen ◽  
Tai On Yau ◽  
Ming Fu ◽  
Vincent Chi Hang Lui ◽  
...  
Keyword(s):  
Nervous System ◽  
Neural Crest ◽  
Enteric Nervous System ◽  
System Development ◽  
Nervous System Development ◽  
Enhancer Element ◽  
Enteric Nervous System Development

scholarly journals Ablation of Ezh2 in neural crest cells leads to aberrant enteric nervous system development in mice

PLoS ONE ◽  
2018 ◽  
Vol 13 (8) ◽  
pp. e0203391
Author(s):  
Hana Kim ◽  
Ingeborg M. Langohr ◽  
Mohammad Faisal ◽  
Margaret McNulty ◽  
Caitlin Thorn ◽  
...  
Keyword(s):  
Nervous System ◽  
Neural Crest ◽  
Enteric Nervous System ◽  
System Development ◽  
Neural Crest Cells ◽  
Nervous System Development ◽  
Enteric Nervous System Development

scholarly journals Meis3 is required for neural crest invasion of the gut during zebrafish enteric nervous system development

2015 ◽  
Vol 26 (21) ◽  
pp. 3728-3740 ◽  
Author(s):  
Rosa A. Uribe ◽  
Marianne E. Bronner
Keyword(s):  
Nervous System ◽  
Neural Crest ◽  
Enteric Nervous System ◽  
Molecular Mechanisms ◽  
System Development ◽  
Neural Crest Cells ◽  
Nervous System Development ◽  
Shh Pathway ◽  
Early Migration ◽  
Enteric Nervous System Development

During development, vagal neural crest cells fated to contribute to the enteric nervous system migrate ventrally away from the neural tube toward and along the primitive gut. The molecular mechanisms that regulate their early migration en route to and entry into the gut remain elusive. Here we show that the transcription factor meis3 is expressed along vagal neural crest pathways. Meis3 loss of function results in a reduction in migration efficiency, cell number, and the mitotic activity of neural crest cells in the vicinity of the gut but has no effect on neural crest or gut specification. Later, during enteric nervous system differentiation, Meis3-depleted embryos exhibit colonic aganglionosis, a disorder in which the hindgut is devoid of neurons. Accordingly, the expression of Shh pathway components, previously shown to have a role in the etiology of Hirschsprung’s disease, was misregulated within the gut after loss of Meis3. Taken together, these findings support a model in which Meis3 is required for neural crest proliferation, migration into, and colonization of the gut such that its loss leads to severe defects in enteric nervous system development.

scholarly journals Changes in Nicotinic Neurotransmission during Enteric Nervous System Development

2015 ◽  
Vol 35 (18) ◽  
pp. 7106-7115 ◽  
Author(s):  
J. P. P. Foong ◽  
C. S. Hirst ◽  
M. M. Hao ◽  
S. J. McKeown ◽  
W. Boesmans ◽  
...  
Keyword(s):  
Nervous System ◽  
Enteric Nervous System ◽  
System Development ◽  
Nervous System Development ◽  
Enteric Nervous System Development

scholarly journals Testing the Ret and Sema3d genetic interaction in mouse enteric nervous system development

2017 ◽  
Vol 26 (10) ◽  
pp. 1811-1820 ◽  
Author(s):  
Ashish Kapoor ◽  
Dallas R. Auer ◽  
Dongwon Lee ◽  
Sumantra Chatterjee ◽  
Aravinda Chakravarti
Keyword(s):  
Nervous System ◽  
Enteric Nervous System ◽  
Genetic Interaction ◽  
System Development ◽  
Nervous System Development ◽  
Enteric Nervous System Development
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