scholarly journals The Extract from Artemisia annua Linné. Induces p53-independent Apoptosis through Mitochondrial Signaling Pathway in A549 Lung Cancer Cells

2016 ◽  
Vol 26 (8) ◽  
pp. 887-894
Author(s):  
Bo-Min Kim ◽  
Guen-Tae Kim ◽  
Eun-Ji Kim ◽  
Eun-Gyeong Lim ◽  
Sang-Yong Kim ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Cells ◽  
Signaling Pathway ◽  
Artemisia Annua ◽  
Lung Cancer Cells ◽  
Mitochondrial Signaling ◽  
A549 Lung

Diallyl disulphide suppresses the cannonical Wnt signaling pathway and reverses the fibronectin-induced epithelial mesenchymal transition of A549 lung cancer cells

2019 ◽  
Vol 10 (1) ◽  
pp. 191-202 ◽  
Author(s):  
Bornita Das ◽  
Dona Sinha
Keyword(s):  
Lung Cancer ◽  
Wnt Signaling ◽  
Cancer Cells ◽  
Signaling Pathway ◽  
Epithelial Mesenchymal Transition ◽  
Wnt Signaling Pathway ◽  
Lung Cancer Cells ◽  
Mesenchymal Transition ◽  
A549 Lung

DADS reflected the potential of reversal of FN-induced EMT by inhibition of Wnt signaling in A549 lung cancer cells.

scholarly journals Nurr1 promotes lung cancer apoptosis via enhancing mitochondrial stress and p53-Drp1 pathway

2019 ◽  
Vol 14 (1) ◽  
pp. 262-274
Author(s):  
Shu Zhao ◽  
Peng Li ◽  
Peng Wang ◽  
Jing Yang ◽  
Peng Song ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Mitochondrial Dysfunction ◽  
Cancer Cells ◽  
Signaling Pathway ◽  
A549 Cells ◽  
Lung Cancer Cells ◽  
Lung Cancer Death ◽  
Mitochondrial Stress ◽  
Mitochondrial Homeostasis ◽  
A549 Lung

AbstractObjectiveMitochondrial homeostasis is vital for the progression of lung cancer. Nurr1 has been identified as a novel mediator of mitochondrial homeostasis in several types of cancers. The aim of our study was to investigate whether Nurr1 modulates the viability of A549 lung cancer cells by inducing mitochondrial dysfunction, with a focus on the p53-Drp1 signaling pathway.Methodswestern blotting, ELISA and immunofluorescence assay was used to verify the alterations of cell death. siRNA was used to determine the role of p53-Drp1 pathway in lung cancer death.ResultsNurr1 was downregulated in A549 lung cancer cells compared to normal pulmonary epithelial cells. Interestingly, overexpression of Nurr1 reduced the viability of A549 lung cancer cells by activating apoptosis and mitochondrial stress. At the molecular level, we provide data to support the regulatory effects of Nurr1 on the p53-Drp1 signaling pathway. Blockade of the p53-Drp1 signaling pathway abolished the proapoptotic action of Nurr1 on A549 cells and sustained mitochondrial homeostasis.ConclusionTaken together, our results depict the tumor-suppressive role played by Nurr1 in A549 lung cancer in vitro and show that the anticancer effects of Nurr1 are executed via triggering of mitochondrial dysfunction and activation of the p53-Drp1 signaling pathway.

scholarly journals Uncoordinated 51-like kinase 2 signaling pathway regulates epithelial-mesenchymal transition in A549 lung cancer cells

FEBS Letters ◽  
2016 ◽  
Vol 590 (9) ◽  
pp. 1365-1374 ◽  
Author(s):  
Young Hwan Kim ◽  
Seung Hoon Baek ◽  
Eun Kyoung Kim ◽  
Jung Min Ha ◽  
Seo Yeon Jin ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Cells ◽  
Signaling Pathway ◽  
Epithelial Mesenchymal Transition ◽  
Lung Cancer Cells ◽  
Mesenchymal Transition ◽  
A549 Lung
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