scholarly journals BOS‑93, a novel bromophenol derivative, induces apoptosis and autophagy in human A549 lung cancer cells via PI3K/Akt/mTOR and MAPK signaling pathway

2019 ◽  
Author(s):  
Chuanlong Guo ◽  
Lijun Wang ◽  
Yue Zhao ◽  
Bo Jiang ◽  
Jiao Luo ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Cells ◽  
Signaling Pathway ◽  
Mapk Signaling ◽  
Mapk Signaling Pathway ◽  
Lung Cancer Cells ◽  
Human A549 ◽  
A549 Lung

Sevoflurane inhibits invasion and migration of lung cancer cells by inactivating the p38 MAPK signaling pathway

2012 ◽  
Vol 26 (3) ◽  
pp. 381-392 ◽  
Author(s):  
Hua Liang ◽  
Miaoning Gu ◽  
Chengxiang Yang ◽  
Hanbing Wang ◽  
Xianjie Wen ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Cells ◽  
Signaling Pathway ◽  
P38 Mapk ◽  
Mapk Signaling ◽  
Mapk Signaling Pathway ◽  
Lung Cancer Cells ◽  
Invasion And Migration ◽  
And Migration

TRIM45 Suppresses the Development of Non-small Cell Lung Cancer

2020 ◽  
Vol 20 (4) ◽  
pp. 299-306
Author(s):  
Xiyang Peng ◽  
Yao Wen ◽  
Lagabaiyila Zha ◽  
Jian Zhuang ◽  
Li Lin ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cancer Cells ◽  
Signaling Pathway ◽  
Cell Lung Cancer ◽  
Mapk Signaling ◽  
Small Cell ◽  
Mapk Signaling Pathway ◽  
Lung Cancer Cells ◽  
Small Cell Lung

Background: Previously, we first identified the human tripartite motifcontaining protein 45 (TRIM45) acts as a novel transcriptional repressor in mitogenactivated protein kinase (MAPK) signaling pathway. After that, the inhibitory role of TRIM45 in the development of tumor was gradually unveiled. However, the function of TRIM45 in the tumorigenesis of lung cancer has not been characterized. Methods and Results: In this study, we found that TRIM45 was up-regulated in earlystage human non-small-cell lung cancer (NSCLC) tissues. Overexpression of TRIM45 in lung cancer cells induces G1 arrest and promotes apoptosis, which accompanied by upregulated expression of RB, p16, p53, p27Kip1, and Caspase3 and down-regulated expression of CyclinE1 and CyclinE2. Further detection of the expression of the molecules in the MAPK signaling pathway revealed that overexpression of TRIM45 in lung cancer cells promotes phosphorylated p38 (p-p38) activation and inhibits phosphorylated ERK (p-ERK) activation. In accordance with this, p-p38 is increased while p-ERK is decreased in lung cancer tissues. Conclusion: These findings indicate that TRIM45 plays an inhibitory role in the tumorigenesis of lung cancer. High-level expression of TRIM45 in lung cancer tissue may promote cell apoptosis by activating p38 signal and inhibit proliferation by down-regulating p-ERK, which provides a new clue for understanding the tumorigenesis of lung cancer.

Diallyl disulphide suppresses the cannonical Wnt signaling pathway and reverses the fibronectin-induced epithelial mesenchymal transition of A549 lung cancer cells

2019 ◽  
Vol 10 (1) ◽  
pp. 191-202 ◽  
Author(s):  
Bornita Das ◽  
Dona Sinha
Keyword(s):  
Lung Cancer ◽  
Wnt Signaling ◽  
Cancer Cells ◽  
Signaling Pathway ◽  
Epithelial Mesenchymal Transition ◽  
Wnt Signaling Pathway ◽  
Lung Cancer Cells ◽  
Mesenchymal Transition ◽  
A549 Lung

DADS reflected the potential of reversal of FN-induced EMT by inhibition of Wnt signaling in A549 lung cancer cells.

Citrus lemon essential oil nanoemulsion (CLEO-NE), a safe cell-depended apoptosis inducer in human A549 lung cancer cells with anti-angiogenic activity

2020 ◽  
Vol 37 (5) ◽  
pp. 394-402
Author(s):  
Elnaz Yousefian Rad ◽  
Masoud Homayouni Tabrizi ◽  
Pouran Ardalan ◽  
Seyed Mohammad Reza Seyedi ◽  
Samira Yadamani ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Essential Oil ◽  
Cancer Cells ◽  
Lung Cancer Cells ◽  
Angiogenic Activity ◽  
Apoptosis Inducer ◽  
Human A549 ◽  
A549 Lung

scholarly journals Regulation of cytotoxicity and apoptosis-associated pathways contributes to the enhancement of efficacy of cisplatin by baicalein adjuvant in human A549 lung cancer cells

2017 ◽  
Vol 13 (4) ◽  
pp. 2799-2804 ◽  
Author(s):  
Suparata Kiartivich ◽  
Ying Wei ◽  
Jiaqi Liu ◽  
Rungtip Soiampornkul ◽  
Mihui Li ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Cells ◽  
Lung Cancer Cells ◽  
Human A549 ◽  
A549 Lung
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