Photo-cross-linked poly(alkylene-co-tartrate) biodegradable matrices for implantable controlled drug delivery and other biomedical applications

2012 ◽  
pp. BMP42
Author(s):  
Ahmad Abuhelwa ◽  
Mohammed Shaker ◽  
Husam M Younes
Keyword(s):  
Drug Delivery ◽  
Biomedical Applications ◽  
Controlled Drug Delivery

Nanoformulations of core–shell type hydroxyapatite-coated gum acacia with enhanced bioactivity and controlled drug delivery for biomedical applications

2020 ◽  
Vol 44 (17) ◽  
pp. 7175-7185 ◽  
Author(s):  
Varun Prasath Padmanabhan ◽  
Subha Balakrishnan ◽  
Ravichandran Kulandaivelu ◽  
Sankara Narayanan T. S. N. ◽  
Muthukrishnan Lakshmipathy ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Antibacterial Activity ◽  
Biomedical Applications ◽  
Controlled Drug Delivery ◽  
Core Shell ◽  
Gum Acacia ◽  
Shell Type

In this work, nanospherical hydroxyapatite (HAP) was prepared that has combined properties of controlled drug delivery, biocompatibility, and antibacterial activity to have applications in the biomedical sector.

In Situ Generation of Polyaniline inside Zeolite Pores for Retention of Ions and for Controlled Drug Delivery

2013 ◽  
Vol 583 ◽  
pp. 91-94 ◽  
Author(s):  
Aurelia Cristina Nechifor ◽  
Alexandrina Ivan ◽  
Stefan Ioan Voicu ◽  
Valeriu Danciulescu ◽  
Roxana Trusca
Keyword(s):  
Drug Delivery ◽  
Composite Materials ◽  
Biomedical Applications ◽  
Controlled Drug Delivery ◽  
Sodium Vanadate ◽  
Biological Interest

In order to improve the capabilities of zeolites for biomedical applications, new composite materials based on polyaniline in-situ generated inside zeolite pores were developed. As precursors for polyaniline several monomers (like aniline and p-phnylenediamine) were used and different oxidant systems (like ammonium peroxodisulphate/HCl, sodium vanadate/ethylic alcohol) were studied and were used for the separation of different biological interest ions and release of antibiotics.

scholarly journals Biocompatible Polymers Combined with Cyclodextrins: Fascinating Materials for Drug Delivery Applications

Molecules ◽  
2020 ◽  
Vol 25 (15) ◽  
pp. 3404 ◽  
Author(s):  
Bartłomiej Kost ◽  
Marek Brzeziński ◽  
Marta Socka ◽  
Małgorzata Baśko ◽  
Tadeusz Biela
Keyword(s):  
Drug Delivery ◽  
Polyethylene Oxide ◽  
Biomedical Applications ◽  
Controlled Drug Delivery ◽  
Natural Polymers ◽  
Supramolecular Systems ◽  
Aliphatic Polyesters ◽  
Different Types ◽  
Functional Biomaterials ◽  
Synthetic And Natural Polymers

Cyclodextrins (CD) are a group of cyclic oligosaccharides with a cavity/specific structure that enables to form inclusion complexes (IC) with a variety of molecules through non-covalent host-guest interactions. By an elegant combination of CD with biocompatible, synthetic and natural polymers, different types of universal drug delivery systems with dynamic/reversible properties have been generated. This review presents the design of nano- and micro-carriers, hydrogels, and fibres based on the polymer/CD supramolecular systems highlighting their possible biomedical applications. Application of the most prominent hydrophobic aliphatic polyesters that exhibit biodegradability, represented by polylactide and polycaprolactone, is described first. Subsequently, particular attention is focused on materials obtained from hydrophilic polyethylene oxide. Moreover, examples are also presented for grafting of CD on polysaccharides. In summary, we show the application of host-guest interactions in multi-component functional biomaterials for controlled drug delivery.

scholarly journals Biodegradable and pH Sensitive Peptide Based Hydrogel as Controlled Release System for Antibacterial Wound Dressing Application

Molecules ◽  
2018 ◽  
Vol 23 (12) ◽  
pp. 3383 ◽  
Author(s):  
Jie Zhu ◽  
Hua Han ◽  
Ting-Ting Ye ◽  
Fa-Xue Li ◽  
Xue-Li Wang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Wound Dressing ◽  
Biomedical Applications ◽  
Drug Delivery Systems ◽  
Controlled Drug Delivery ◽  
Delivery Systems ◽  
Hybrid Hydrogel ◽  
Antibacterial Studies ◽  
Hybrid Hydrogels ◽  
Stimuli Sensitive

The stimuli-sensitive and biodegradable hydrogels are promising biomaterials as controlled drug delivery systems for diverse biomedical applications. In this study, we construct hybrid hydrogels combined with peptide-based bis-acrylate and acrylic acid (AAc). The peptide-based bis-acrylate/AAc hybrid hydrogel displays an interconnected and porous structure by scanning electron microscopy (SEM) observation and exhibits pH-dependent swelling property. The biodegradation of hybrid hydrogels was characterized by SEM and weight loss, and the results showed the hydrogels have a good enzymatic biodegradation property. The mechanical and cytotoxicity properties of the hydrogels were also tested. Besides, triclosan was preloaded during the hydrogel formation for drug release and antibacterial studies. In summary, the peptide-based bis-acrylate/AAc hydrogel with stimuli sensitivity and biodegradable property may be excellent candidates as drug delivery systems for antibacterial wound dressing application.

Towards Heterogeneous Biodegradable Nanorods for Controlled Drug Delivery

2008 ◽  
Vol 1138 ◽  
Author(s):  
Shelley Dougherty ◽  
Jianyu Liang
Keyword(s):  
Thin Films ◽  
Drug Delivery ◽  
Drug Release ◽  
Biomedical Applications ◽  
Release Kinetics ◽  
Controlled Drug Delivery ◽  
Unique Combination ◽  
Multiple Functions ◽  
One Dimensional ◽  
Heterogeneous Polymer

AbstractHeterogeneous, one-dimensional (1D) nanomaterials, such as nanorods and nanowires, have been utilized for a variety of different biomedical applications because they offer a unique combination of properties and provide a material platform for integrating multiple functions. In this paper, we propose a template-assisted wetting approach to fabricate segmented polymer nanorods using biodegradable polymers for controlled drug delivery. Our previous work with polystyrene (PS) and poly(methyl methacrylate) (PMMA) heterogeneous, segmented nanorods is described briefly to introduce our current preliminary work with the fabrication of homogeneous biodegradable nanorods and drug release from polymer thin films. Since the template-assisted fabrication approach provides us unprecedented control over the size, spacing, and length of the heterogeneous polymer nanorods, this technique will provide for the opportunity to evaluate drug release kinetics as a function of the segment spacing, size of the nanorods, and aspect ratio in the future.

Emerging Biomedical Applications of Algal Polysaccharides

2019 ◽  
Vol 25 (11) ◽  
pp. 1335-1344 ◽  
Author(s):  
Maryam Rahmati ◽  
Zahra Alipanahi ◽  
Masoud Mozafari
Keyword(s):  
Drug Delivery ◽  
Biomedical Applications ◽  
Drug Delivery Systems ◽  
Antimicrobial Properties ◽  
Controlled Drug Delivery ◽  
Delivery Systems ◽  
Stimuli Responsive ◽  
Swelling Properties ◽  
Gelling Properties ◽  
Algal Polysaccharides

Background: Over the past two decades, there have been substantial progress and a growing body of research on using natural polymeric biomaterials in emerging biomedical applications. Among different natural biopolymers, polysaccharides have gained considerable attraction among biomedical scientists and surgeons due to their biocompatibility, biodegradability, anti-inflammatory, and antimicrobial properties. In recent years, algalbased polysaccharides including agar, alginate, and carrageenan, have been broadly suggested for different biomedical applications. Methods: The aim of this paper is discussing various possible applications of algal-based polysaccharides in biomedical engineering particularly in controlled drug delivery systems. The main properties of each algal polysaccharide will be discussed, and particular drug delivery applications will be presented. Results: Algal polysaccharides can be detected in a group of photosynthetic unite as their key biomass constituents. They provide a range of variety in their size, shape, liquefaction, chemical stability, and crosslinking ability. In addition, algal polysaccharides have shown exceptional gelling properties including stimuli-responsive behavior, softness, and swelling properties. Conclusion: All the mentioned properties of alga polysaccharides lead to their successful usage in biomedical applications specially targeted and controlled drug delivery systems such as particles, capsules, and gels.

scholarly journals Promises, facts and challenges for graphene in biomedical applications

2017 ◽  
Vol 46 (15) ◽  
pp. 4400-4416 ◽  
Author(s):  
Giacomo Reina ◽  
José Miguel González-Domínguez ◽  
Alejandro Criado ◽  
Ester Vázquez ◽  
Alberto Bianco ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Biomedical Applications ◽  
Controlled Drug Delivery ◽  
Biomedical Field

Graphene-based materials can contribute favorably to the biomedical field. Particularly promising areas of development include sensors, controlled drug delivery and tissue engineering.

Graphene as a chain extender of polyurethanes for biomedical applications

RSC Advances ◽  
2016 ◽  
Vol 6 (63) ◽  
pp. 58628-58640 ◽  
Author(s):  
Dinesh K. Patel ◽  
Rajesh K. Singh ◽  
Santosh K. Singh ◽  
Vinod K. Aswal ◽  
Dipak Rana ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Biomedical Applications ◽  
Controlled Drug Delivery ◽  
Chain Extender ◽  
Delivery Vehicle ◽  
Drug Delivery Vehicle ◽  
A Chain

Chemically tagged graphene nanohybrid for a controlled drug delivery vehicle.

scholarly journals Halloysite nanotubes-polymeric nanocomposites: characteristics, modifications and controlled drug delivery approaches

Cerâmica ◽  
2017 ◽  
Vol 63 (368) ◽  
pp. 423-431 ◽  
Author(s):  
P. C. Ferrari ◽  
F. F. Araujo ◽  
S. A. Pianaro
Keyword(s):  
Drug Delivery ◽  
Biomedical Applications ◽  
Mechanical Performance ◽  
Controlled Drug Delivery ◽  
Empty Space ◽  
Halloysite Nanotubes ◽  
Tubular Structure ◽  
Biologically Active ◽  
Polymeric Nanocomposites ◽  
Low Cytotoxicity

Abstract Halloysite nanotubes (HNTs) are aluminosilicate nanoclay mineral which have a hollow tubular structure and occurs naturally. They are biocompatible and viable carrier for inclusion of biologically active molecules due to the empty space inside the tubular structure. In this article, the HNTs main characteristics, and the HNTs-polymeric nanocomposite formation and their potential application as improvement of the mechanical performance of polymers and entrapment of hydrophilic and lipophilic substances are summarized. Recent works covering the increment of HNTs-polymeric nanocomposites and presenting promising employment of these systems as nanosized carrier, being suitable for pharmaceutical and biomedical applications, based on earlier evidence in literature of its nature to sustain the release of loaded drugs, presenting low cytotoxicity, and providing evidence for controlled drug delivery are reviewed.

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